MiR-135b might be a potential therapeutic target in the treatment of myocardial infarction

Hu, Hai-Ling; Gao, Shuhong; Pan, Jie

doi:10.1016/j.ijcard.2020.08.084

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The Therapeutic Application Of MI Associated Mirnas1

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“…The results of experiments demonstrated an increase in the expression of miR-539 and a decrease in the expression of MEK, which led not only to suppressed proliferation but also to apoptosis and autophagy of H9C2 cells. Although other miRNAs also have been proposed to have anti-myocardial infarction effects, it still needs further experimental verification (Xiang and Yang, 2020;Zhu et al, 2021b;Hu et al, 2021).…”

Section: The Therapeutic Application Of MI Associated Mirnasmentioning

confidence: 99%

Targeting Epigenetics and Non-coding RNAs in Myocardial Infarction: From Mechanisms to Therapeutics

Chen¹,

Liu²,

Ma³

et al. 2021

Front. Genet.

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Myocardial infarction (MI) is a complicated pathology triggered by numerous environmental and genetic factors. Understanding the effect of epigenetic regulation mechanisms on the cardiovascular disease would advance the field and promote prophylactic methods targeting epigenetic mechanisms. Genetic screening guides individualised MI therapies and surveillance. The present review reported the latest development on the epigenetic regulation of MI in terms of DNA methylation, histone modifications, and microRNA-dependent MI mechanisms and the novel therapies based on epigenetics.

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Section: The Therapeutic Application Of MI Associated Mirnasmentioning

confidence: 99%