MiR-133a acts as an anti-oncogene in Hepatocellular carcinoma by inhibiting FOSL2 through TGF-β/Smad3 signaling pathway

Sun, Lu; Guo, Zhixian; Sun, Jun; Li, Jingjing; Dong, Zihui; Zhang, Yize; Chen, Jianan; Kan, Quancheng; Yu, Zujiang

doi:10.1016/j.biopha.2018.07.151

Cited by 36 publications

(28 citation statements)

References 37 publications

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“…During this process, multiple molecules or signaling pathways were revealed to be abnormally activated (Hanahan & Weinberg, ). miRNA is reported to play crucial roles in the progression of human cancer including HCC (Chen et al, ; Sun et al, ; Yang et al, ). For instance, miR‐133a was found to be a tumor suppressive miRNA to inhibit HCC progression through targeting Fos‐related antigen 2 (601575)/transforming growth factor‐β/SMAD family member 3 (603109) signaling pathway (Sun et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…miRNA is reported to play crucial roles in the progression of human cancer including HCC (Chen et al, ; Sun et al, ; Yang et al, ). For instance, miR‐133a was found to be a tumor suppressive miRNA to inhibit HCC progression through targeting Fos‐related antigen 2 (601575)/transforming growth factor‐β/SMAD family member 3 (603109) signaling pathway (Sun et al, ). miR‐302c‐3p also exhibited a tumor suppressive role and inhibit HCC cell migration and invasion via targeting tumor necrosis factor receptor associated factor 4 (602464) (Yang et al, ).…”

Section: Discussionmentioning

confidence: 99%

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miR‐584‐5p regulates hepatocellular carcinoma cell migration and invasion through targeting KCNE2

Wei

Wang

et al. 2019

Molec Gen & Gen Med

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Background Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancer type. This study was aimed to investigate the role of microRNA‐584‐5p (miR‐584‐5p) in regulating HCC progression. Methods The expression of miR‐584‐5p in HCC cell lines was analyzed by quantitative real‐time polymerase chain reaction. Effects of miR‐584‐5p depletion on HCC cell proliferation, migration, and invasion in vitro were analyzed by cell counting kit‐8 assay, wound‐healing assay, and transwell invasion assay. miR‐584‐5p targeting potassium voltage‐gated channel subfamily E regulatory subunit 2 (KCNE2) was identified using bioinformatics algorithm and dual‐luciferase activity reporter assay. Kaplan–Meier Plotter website was used to investigate the effect of miR‐584‐5p or KCNE2 expression on the overall survival of HCC patients. Results In vitro functional assays showed miR‐584‐5p depletion decreased HCC cell proliferation, cell migration, and cell invasion. Moreover, miR‐584‐5p functions by directly targeting KCNE2, and it in turn, mediates the effects of miR‐584‐5p on HCC cell behaviors. Conclusions These results demonstrated that miR‐584‐5p functions as an oncogenic miRNA in HCC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

miR‐584‐5p regulates hepatocellular carcinoma cell migration and invasion through targeting KCNE2

Wei

Wang

et al. 2019

Molec Gen & Gen Med

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“…miRNAs are small noncoding RNAs of ~20 nucleotides that bind to conserved 3'-untranslated region sequences of their target mRNAs and induce the inhibition of their translation (34). Thereby miRNAs regulate gene transcription and expression to modulate important physiological functions (35,36). miRNAs serve a vital role in numerous pathological events and in the cell response to various stresses (35).…”

Section: Estrogen May Serve An Inhibitory Role In Sex Disparity In Hcmentioning

confidence: 99%

“…In the hepatocarcinogenic process, numerous miRNAs show abnormal expression in HCC tissues compared with paired adjacent nontumorous tissues. Therefore, miRNAs are recognized as a group of host genetic factors associated with hepatocarcinogenesis (36)(37)(38). The cross-linking of some miRNAs with ER is involved in the sex difference in HCC.…”

Section: Estrogen May Serve An Inhibitory Role In Sex Disparity In Hcmentioning

confidence: 99%

Recent advances in the molecular mechanism of sex disparity in hepatocellular carcinoma (Review)

Jia

et al. 2019

Oncol Lett

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Hepatocellular carcinoma (HCC) is more frequently observed and aggressive in men compared with women. Increasing evidence demonstrates that the sex disparity appears to be mediated by the stimulatory effects of androgens and the protective effects of estrogen in the development and progression of HCC. In the past few decades, studies on the sex difference of HCC mainly focused on the effect of sex hormones on the transactivation of hepatitis B virus X protein and the release of inflammatory cytokines, and these studies have further intensified in recent years. Sex hormones are also involved in genetic alterations and DNA damage repair in hepatocytes through binding to their specific cellular receptors and affecting the corresponding signaling pathways. Furthermore, the theory of sex chromosomes participating in HCC has been considered. The present review discussed the recent advances in the molecular mechanisms of sex disparity in HCC, with the aim of improving the understanding of the underlying critical factors and exploring more effective methods for the prevention and treatment of HCC. Contents

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“…It has been shown that miR-133a-3p acts as a tumor suppressor in BC.Numerous studies demonstrated that miR-133a inhibits cell proliferation, migration, and invasion in various tumors by targeting to different signaling pathways, such as caspase signaling pathway, insulin/IGF signaling pathway, and EGFR signaling pathway (21)(22)(23)(24)(25)(26)(27)(28). The connecting between the importance of miR-133a in tumorigenesis and significant downregulation of miR-133a in BC has shed light on the molecular mechanism of miRNA-133a in the tumorigenesis of BC.…”

Section: Discussionmentioning

confidence: 99%

Signatures containing miR-133a identified by large scale miRNA profiling in bladder cancer

Jiang

Zhu²,

Xiang

et al. 2019

Preprint

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Background: Identifying bladder cancer-specific miRNA expression signatures by large scale miRNA profiling Methods：30 bladder cancer (BC) tissue samples and matched adjacent normal bladder tissue samples from patients with BC were collected and were divided into two groups； a training group and a blind testing group. Expressions of 1900 miRNAs and controls were detected in a BC miRNA pool and in a normal miRNAs pool, respectively. 380 differential expressed miRNAs between the BC miRNA pool and the normal miRNA pool were selected. The primers for detecting the 380 selected miRNAs and controls were used to generate one 384-well panel. This panel was used to profile miRNA expression of each individual sample in the training group and in the blind testing group. Data analysis was performed using a machine learning approach of a support vector machine classifier with a Student's t-test feature selection procedure. Results： We identified signatures consisting of three or four miRNAs that could distinguish BC from normal controls with an accuracy of 100% in the training model and an accuracy of over 95% in the blind test. All identified signatures contain hsa-miR-133a. We also revealed that the miRNA183-96 cluster and the miR200 cluster are both significantly up-regulated in BC. Conclusions：The identified signatures containing hsa-miR-133a could be used as biomarkers in the diagnosis and prognosis of BC.

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MiR-133a acts as an anti-oncogene in Hepatocellular carcinoma by inhibiting FOSL2 through TGF-β/Smad3 signaling pathway

Cited by 36 publications

References 37 publications

miR‐584‐5p regulates hepatocellular carcinoma cell migration and invasion through targeting KCNE2

miR‐584‐5p regulates hepatocellular carcinoma cell migration and invasion through targeting KCNE2

Recent advances in the molecular mechanism of sex disparity in hepatocellular carcinoma (Review)

Signatures containing miR-133a identified by large scale miRNA profiling in bladder cancer

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