miR‐1322 regulates Ch<scp>REBP</scp> expression via binding a 3′‐<scp>UTR</scp> variant (rs1051943)

Zhang, Ying; Hu, Senlin; Hu, Dong; Jiang, Jian-Gang; Cui, Guanglin; Liu, Xingde; Wang, Dao Wen

doi:10.1111/jcmm.13805

Cited by 4 publications

(3 citation statements)

References 33 publications

(56 reference statements)

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“…chreBP expression is positively related to the degree of hepatic steatosis in human and mice with naFld (32). our previous study also confirmed the decreased expression of chreBP attenuated lipid synthesis and accumulation (33). as expected, the HFd mouse demonstrated increased chreBP-mediated fat syntheses.…”

Section: Discussionsupporting

confidence: 82%

Trimetazidine improves hepatic lipogenesis and steatosis in non‑alcoholic fatty liver disease via AMPK‑ChREBP pathway

Zhang

et al. 2020

Mol Med Rep

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clinical studies have demonstrated that trimetazidine (TMZ) possesses a synergistic hypolipidemic effect together with statins, but the underlying mechanism remains to be elucidated. The present study aimed to investigate the role of TMZ in non-alcoholic fatty liver disease (naFld). By investigating the TMZ treatment of NAFLD, it was identified that high-fat diet (HFD) mice exhibit significant changes in several physiologic indices, including body weight, plasma lipids and glucose tolerance. notably, hepatocyte bullous steatosis and fibrosis in HFD mice are greatly attenuated by 8 weeks of TMZ treatments. The results of the present study also indicated that the expression of carbohydrate-responsive element-binding protein (chreBP), fatty acid synthase and acetyl-CoA carboxylase were all significantly reduced in the HFd + TMZ group compared with the HFd group. in order to confirm the hypothesis in vitro, the palmitate-treated liver cancer cell line (HepG2) was employed and similar results were obtained in TMZ-treated HepG2 cells. Furthermore, TMZ markedly upregulated the aMP-activated protein kinase (aMPK) signaling pathway and reduced the expression of forkhead box o1 (FoXo1) in the cells, while these effects controlled by TMZ were abolished by the aMPK inhibitor compound c. The present study reported that knockdown of FoXo1 expression by FoXo1 small interfering rna resulted in a reduction of chreBP protein expression and post-transcriptional activity. In summary, for the first time, to the best of the authors' knowledge, the present study revealed a novel role of TMZ in hepatic steatosis; TMZ ameliorated chreBP-induced de novo lipogenesis by activating the aMPK-FoXo1 pathway.

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Section: Discussionsupporting

confidence: 82%

Trimetazidine improves hepatic lipogenesis and steatosis in non‑alcoholic fatty liver disease via AMPK‑ChREBP pathway

Zhang

et al. 2020

Mol Med Rep

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“…Might the Myc and Mlx Networks “communicate” by virtue of microRNAs (miRNAs) whose transcriptional regulation by one Network might post-transcriptionally regulate members of the other Network? Although Myc is known to induce the expression of many miRNAs and Myc mRNA is itself a miRNA target, little information exists regarding miRNAs in the regulation of or by any members of the Mlx Network [ 171 , 172 , 173 , 174 ].…”

Section: Discussionmentioning

confidence: 99%

Regulation of Normal and Neoplastic Proliferation and Metabolism by the Extended Myc Network

Prochownik

2022

Cells

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The Myc Network, comprising a small assemblage of bHLH-ZIP transcription factors, regulates many hundreds to thousands of genes involved in proliferation, energy metabolism, translation and other activities. A structurally and functionally related set of factors known as the Mlx Network also supervises some of these same functions via the regulation of a more limited but overlapping transcriptional repertoire. Target gene co-regulation by these two Networks is the result of their sharing of three members that suppress target gene expression as well as by the ability of both Network’s members to cross-bind one another’s consensus DNA sites. The two Networks also differ in that the Mlx Network’s control over transcription is positively regulated by several glycolytic pathway intermediates and other metabolites. These distinctive properties, functions and tissue expression patterns potentially allow for sensitive control of gene regulation in ways that are differentially responsive to environmental and metabolic cues while allowing for them to be both rapid and of limited duration. This review explores how such control might occur. It further discusses how the actual functional dependencies of the Myc and Mlx Networks rely upon cellular context and how they may differ between normal and neoplastic cells. Finally, consideration is given to how future studies may permit a more refined understanding of the functional interrelationships between the two Networks.

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“…Previous research has shown that miR-1322 can regulate ECRG2 and is a potential diagnostic biomarker for esophageal squamous cell carcinoma. 40 In addition, Circ-HOMER1 enhances the inhibition of miR-1322 on CXCL6 to regulate the growth and aggressiveness of hepatocellular carcinoma. 41 We used a public prediction database to confirm that miR-1322 directly regulated CCL20 expression.…”

Section: Discussionmentioning

confidence: 99%

Fusobacterium nucleatum promotes colorectal cancer metastasis through miR-1322/CCL20 axis and M2 polarization

et al. 2021

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Colorectal cancer (CRC) is one of the most common malignant tumors and is associated with Fusobacterium nucleatum ( F. nucleatum, Fn ) infection. In this study, we explored the role of F. nucleatum in the CRC metastasis. Our results showed that the abundance of F. nucleatum was enriched in the feces and tumors of patients with CRC and tended to increase in stage IV compared to stage I in patients with metastatic CRC. Tumor-derived CCL20 activated by F. nucleatum not only increases CRC metastasis, but also participates in the reprograming of the tumor microenvironment. F. nucleatum promoted macrophage infiltration through CCL20 activation and simultaneously induced M2 macrophage polarization, enhancing the metastasis of CRC. In addition, we identified using database prediction and luciferase activity hat miR-1322, a candidate regulatory micro-RNA, could bind to CCL20 directly. F. nucleatum infection decreased the expression of miR-1322 by activating the NF-κB signaling pathway in CRC cells. In conclusion, F. nucleatum promotes CRC metastasis through the miR-1322/CCL20 axis and M2 polarization.

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miR‐1322 regulates ChREBP expression via binding a 3′‐UTR variant (rs1051943)

Cited by 4 publications

References 33 publications

Trimetazidine improves hepatic lipogenesis and steatosis in non‑alcoholic fatty liver disease via AMPK‑ChREBP pathway

Trimetazidine improves hepatic lipogenesis and steatosis in non‑alcoholic fatty liver disease via AMPK‑ChREBP pathway

Regulation of Normal and Neoplastic Proliferation and Metabolism by the Extended Myc Network

Fusobacterium nucleatum promotes colorectal cancer metastasis through miR-1322/CCL20 axis and M2 polarization

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