miR-132 inhibits lipopolysaccharide-induced inflammation in alveolar macrophages by the cholinergic anti-inflammatory pathway

Liu, Fen; Li, Yong; Jiang, Rong; Nie, Chuan; Zeng, Zhenguo; Zhao, Ning; Huang, Caixue; Shao, Qiang; Ding, Chengzhi; Cheng, Qi; Xia, Liang; Zeng, Erming; Qian, Kun

doi:10.3109/01902148.2015.1004206

Cited by 72 publications

(56 citation statements)

References 25 publications

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“…Additionally, miR-132 has been shown to elicit anti-inflammatory effects in alveolar macrophages (59). Treatment of rat alveolar macrophages with LPS resulted in an increase in miR-132 levels together with high levels of TNF-α, IL-1β, and IL-6 (59).…”

Section: Functional Role Of Micrornas In the Regulation Of Macrophmentioning

confidence: 99%

Section: Functional Role Of Micrornas In the Regulation Of Macrophmentioning

confidence: 99%

“…Treatment of rat alveolar macrophages with LPS resulted in an increase in miR-132 levels together with high levels of TNF-α, IL-1β, and IL-6 (59). Coinciding with the elevation of miR-132 was an initial increase in AChE protein levels but AChE levels declined at 24 h post-LPS treatment (59). Transfection of miR-132 mimics in ACh-pretreated macrophages repressed the pro-inflammatory responses upon LPS challenge through inhibition of the NF-κB and STAT3 pathways (59).…”

Section: Functional Role Of Micrornas In the Regulation Of Macrophmentioning

confidence: 99%

“…Coinciding with the elevation of miR-132 was an initial increase in AChE protein levels but AChE levels declined at 24 h post-LPS treatment (59). Transfection of miR-132 mimics in ACh-pretreated macrophages repressed the pro-inflammatory responses upon LPS challenge through inhibition of the NF-κB and STAT3 pathways (59). Conversely, transfection of miR-132 inhibitor in ACh-pretreated macrophages enhanced production of TNF-α, IL-1β, and IL-6 (59).…”

Section: Functional Role Of Micrornas In the Regulation Of Macrophmentioning

confidence: 99%

“…Transfection of miR-132 mimics in ACh-pretreated macrophages repressed the pro-inflammatory responses upon LPS challenge through inhibition of the NF-κB and STAT3 pathways (59). Conversely, transfection of miR-132 inhibitor in ACh-pretreated macrophages enhanced production of TNF-α, IL-1β, and IL-6 (59). Similar to miR-132, miR-146a has the capacity to dampen the inflammatory response in alveolar macrophages (60).…”

Section: Functional Role Of Micrornas In the Regulation Of Macrophmentioning

confidence: 99%

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MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response

Essandoh

Li²,

Huo³

et al. 2016

Shock

451

375

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Monocytes and macrophages are important components of the immune system, specialized in either removing pathogens as part of innate immunity or contributing to adaptive immunity through antigen presentation. Essential to such functions is classical activation (M1) and alternative activation (M2) of macrophages. M1 polarization of macrophages is characterized by production of pro-inflammatory cytokines, antimicrobial and tumoricidal activity, whereas M2 polarization of macrophages is linked to immunosuppression, tumorigenesis, wound repair and elimination of parasites. MiRNAs are small non-coding RNAs with the ability to regulate gene expression and network of cellular processes. A number of studies have determined miRNA expression profiles in M1 and M2 polarized human and murine macrophages using microarray and RT-qPCR arrays techniques. More specifically, miR-9, miR-127, miR-155 and miR-125b have been shown to promote M1 polarization while miR-124, miR-223, miR-34a, let-7c, miR-132, miR-146a and miR-125a-5p induce M2 polarization in macrophages by targeting various transcription factors and adaptor proteins. Further, M1 and M2 phenotypes play distinctive roles in cell growth and progression of inflammation-related diseases such as sepsis, obesity, cancer and multiple sclerosis. Hence, miRNAs that modulate macrophage polarization may have therapeutic potential in the treatment of inflammation-related diseases. This review highlights recent findings in miRNA expression profiles in polarized macrophages from murine and human sources, and summarizes how these miRNAs regulate macrophage polarization. Lastly, therapeutic potential of miRNAs in inflammation-related diseases through modulation of macrophage polarization is also discussed.

show abstract

Section: Functional Role Of Micrornas In the Regulation Of Macrophmentioning

confidence: 99%

Section: Functional Role Of Micrornas In the Regulation Of Macrophmentioning

confidence: 99%

Section: Functional Role Of Micrornas In the Regulation Of Macrophmentioning

confidence: 99%

Section: Functional Role Of Micrornas In the Regulation Of Macrophmentioning

confidence: 99%

Section: Functional Role Of Micrornas In the Regulation Of Macrophmentioning

confidence: 99%

See 3 more Smart Citations

MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response

Essandoh

Li²,

Huo³

et al. 2016

Shock

451

375

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show abstract

Gene Therapy for the Treatment of Chronic Wounds

García-Fuentes¹

2020

Therapeutic Dressings and Wound Healing Applications

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miRNA‐encapsulated abiotic materials and biovectors for cutaneous and oral wound healing: Biogenesis, mechanisms, and delivery nanocarriers

Dey

Yousefiasl

Kumar

et al. 2022

Bioengineering & Transla Med

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MicroRNAs (miRNAs) as therapeutic agents have attracted increasing interest in the past decade owing to their significant effectiveness in treating a wide array of ailments. These polymerases II‐derived noncoding RNAs act through post‐transcriptional controlling of different proteins and their allied pathways. Like other areas of medicine, researchers have utilized miRNAs for managing acute and chronic wounds. The increase in the number of patients suffering from either under‐healing or over‐healing wound demonstrates the limited efficacy of the current wound healing strategies and dictates the demands for simpler approaches with greater efficacy. Various miRNA can be designed to induce pathway beneficial for wound healing. However, the proper design of miRNA and its delivery system for wound healing applications are still challenging due to their limited stability and intracellular delivery. Therefore, new miRNAs are required to be identified and their delivery strategy needs to be optimized. In this review, we discuss the diverse roles of miRNAs in various stages of wound healing and provide an insight on the most recent findings in the nanotechnology and biomaterials field, which might offer opportunities for the development of new strategies for this chronic condition. We also highlight the advances in biomaterials and delivery systems, emphasizing their challenges and resolutions for miRNA‐based wound healing. We further review various biovectors (e.g., adenovirus and lentivirus) and abiotic materials such as organic and inorganic nanomaterials, along with dendrimers and scaffolds, as the delivery systems for miRNA‐based wound healing. Finally, challenges and opportunities for translation of miRNA‐based strategies into clinical applications are discussed.

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miR-132 inhibits lipopolysaccharide-induced inflammation in alveolar macrophages by the cholinergic anti-inflammatory pathway

Abstract: We propose that miR-132 functions as a negative regulator of the inflammatory response in alveolar macrophages by potentiating the cholinergic anti-inflammatory pathway, and represents a potential therapeutic leverage point in modulating inflammatory responses.

Cited by 72 publications

References 25 publications

MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response

MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response

Gene Therapy for the Treatment of Chronic Wounds

miRNA‐encapsulated abiotic materials and biovectors for cutaneous and oral wound healing: Biogenesis, mechanisms, and delivery nanocarriers

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