MiR-130a-3p suppresses colorectal cancer growth by targeting Wnt Family Member 1 (WNT1)

Song, Guang-Lin; Xiao, Ming; Wan, Xiaoya; Deng, Jun; Ling, JunDa; Tian, Ying-Guo; Li, Min; Yin, Jie; Zheng, Ren-Ying; Liu, Guiyuan

doi:10.1080/21655979.2021.1977556

Cited by 17 publications

(10 citation statements)

References 33 publications

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“…Roman-Canal et al also reported a reduction in the level of this miRNA in the study of extracellular vesicles from the peritoneal lavage of EC patients (Roman-Canal et al 2019). MiR-130a-3p is believed to have anti-cancer properties as described in colorectal cancer (Song et al 2021), breast cancer (Kong et al 2018;Poodineh et al 2020), gastric cancer (Jiang et al 2015), 2021) also found that miR-130a-3p may promote proliferation and invasions in cervical cancer. In our study, a low activity was also observed for miR-130b-3p, miR-4319, and miR-379-5p in the early stage of endometrial cancer, which may be associated with the highest EDN1 expression in G1 cancer.…”

Section: Discussionmentioning

confidence: 87%

Endothelin-3 is epigenetically silenced in endometrioid endometrial cancer

Zmarzły¹,

Januszyk²,

Mieszczański

et al. 2022

J Cancer Res Clin Oncol

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Purpose Changes in the activity of endothelins and their receptors may promote neoplastic processes. They can be caused by epigenetic modifications and modulators, but little is known about endothelin-3 (EDN3), particularly in endometrial cancer. The aim of the study was to determine the expression profile of endothelin family and their interactions with miRNAs, and to assess the degree of EDN3 methylation. Methods The study enrolled 45 patients with endometrioid endometrial cancer and 30 patients without neoplastic changes. The expression profile of endothelins and their receptors was determined with mRNA microarrays and RT-qPCR. The miRNA prediction was based on the miRNA microarray experiment and the mirDB tool. The degree of EDN3 methylation was assessed by MSP. Results EDN1 and EDNRA were overexpressed regardless of endometrial cancer grade, which may be due to the lack of regulatory effect of miR-130a-3p and miR-485-3p, respectively. In addition, EDN3 and EDNRB were significantly downregulated. Conclusion The endothelial axis is disturbed in endometrioid endometrial cancer. The observed silencing of EDN3 activity may be mainly due to DNA methylation.

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Section: Discussionmentioning

confidence: 87%

Endothelin-3 is epigenetically silenced in endometrioid endometrial cancer

Zmarzły¹,

Januszyk²,

Mieszczański

et al. 2022

J Cancer Res Clin Oncol

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“…High IRAK1 expression found in CRC is associated with poor prognosis and by suppressing IRAK1 expression it inhibits migration and invasiveness of CRC (Hozaka et al, 2021). MiR-130a-3p expression is low in normal colon tissues, but higher in CRC, and overexpression miR-130a-3p inhibits colorectal cancer cell proliferation (Song et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

Molecular Aspects of Colorectal Cancer Prognosis in 10 years

2022

Nusantara Science and Technology Proceedings

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Colorectal cancer (CRC) ranks third in the world with an increasing mortality rate, prompting an analysis of various studies that have been conducted over the last 10 years. The inclusion criteria of the analyzed research articles were studies involving the molecular aspects of colorectal cancer associated with its prognosis in the last 10 years. The international literature search method was carried out through article data published in Embase, Scopus, and PubMed using keywords: colorectal cancer, molecular aspects, and prognosis. Through the 440 articles found during the first search out, after going through the final selection stage, 29 articles were determined that met the inclusion criteria. The research method that is widely used in the research analyzed is immunohistochemistry accompanied by PCR. Various molecular aspects have been found to play a role in determining carcinogenesis, response to therapy, and the prognosis of CRC. They generally examine aspects of genes and progress towards microRNA and some molecular aspects are still useful in determining the prognosis so they are still being worked on at this time but further research is needed to further complement the existing data about CRC.

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“…Both metabolites upregulated the expression of hsa‐miR‐130a‐3p and hsa‐miR‐625‐5p which have tumor suppressor properties. [ 39,40 ] Thus, the miRNAs upregulated in response to DHPAA and/or HPPA may exert anti‐carcinogenic effects. In the present study, the biological role of aberrantly expressed miRNAs was predicted using a pathway enrichment analysis, where many of the significantly enriched pathways in response to DHPAA and HPPA were in fact implicated in cancer.…”

Section: Discussionmentioning

confidence: 99%

Cranberry Proanthocyanidin and Its Microbial Metabolite 3,4‐Dihydroxyphenylacetic Acid, but Not 3‐(4‐Hydroxyphenyl)‐Propionic Acid, Partially Reverse Pro‐Inflammatory microRNA Responses in Human Intestinal Epithelial Cells

Lofft

Taïbi

Massara

et al. 2022

Molecular Nutrition Food Res

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Scope: The molecular basis underlying the anti-inflammatory and anticarcinogenic properties of cranberries is incompletely understood. The effects of a cranberry proanthocyanidin-rich extract (PAC) and two of its gut microbial metabolites, 3,4-dihydroxyphenylacetic acid (DHPAA) and 3-(4-hydroxyphenyl)-propionic acid (HPPA), on intestinal epithelial cells microRNA (miRNA) expression and their downstream pathways at homeostasis and in inflammatory conditions, are investigated. Methods and Results: The expression of 799 miRNAs is quantitatively assessed in differentiated Caco-2BBe1 cells pre-treated with PAC, DHPAA, or HPPA and stimulated with interleukin (IL)-1𝜷 or not. PAC, DHPAA, and HPPA generate subsets of shared and distinct miRNA responses. At homeostasis, miRNAs affected by the metabolites, but not PAC, targeted genes enriched in kinase, Wnt, and growth factor signaling, cell growth and proliferation, apoptosis, and specific cancer pathways. In an inflammatory environment, PAC and DHPAA, but not HPPA, reverses the expression of 16 and two IL-1𝜷-induced miRNAs, respectively, regulating inflammatory and cancer pathways. Conclusion: miRNA modulation is a novel mechanism for PAC bioactivity in the gut. The gut microbiota may be necessary to unlock these effects at homeostasis and partially in inflammation.

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MiR-130a-3p suppresses colorectal cancer growth by targeting Wnt Family Member 1 (WNT1)

Cited by 17 publications

References 33 publications

Endothelin-3 is epigenetically silenced in endometrioid endometrial cancer

Endothelin-3 is epigenetically silenced in endometrioid endometrial cancer

Molecular Aspects of Colorectal Cancer Prognosis in 10 years

Cranberry Proanthocyanidin and Its Microbial Metabolite 3,4‐Dihydroxyphenylacetic Acid, but Not 3‐(4‐Hydroxyphenyl)‐Propionic Acid, Partially Reverse Pro‐Inflammatory microRNA Responses in Human Intestinal Epithelial Cells

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