MiR-1306-5p predicts favorable prognosis and inhibits proliferation, migration, and invasion of colorectal cancer cells via PI3K/AKT/mTOR pathway

Wang, Wei; Zhang, Jun; Fan, Yunxiu; Zhang, Li

doi:10.1080/15384101.2022.2054245

Cited by 6 publications

(5 citation statements)

References 23 publications

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“…Five miRNAs including miR-93-5p, miR-125a-5p, miR-1306-5p, miR-147b-3p, and miR-190a-5p were selectively retained in cells only in colorectal cancer cell lines ( Figure 5 B, highlighted in lime). All of them were abnormally expressed in colorectal cancer [ 78 , 79 , 80 , 81 , 82 , 83 ]. Selective sorting of functionally important miRNAs into EVs derived from specific cancer cell types might be part of molecular signaling pathways that drive cancer initiation/progression.…”

Section: Resultsmentioning

confidence: 99%

Systematic Assessment of Small RNA Profiling in Human Extracellular Vesicles

Wang,

Chen,

Sheng

et al. 2023

Cancers

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Motivation: Extracellular vesicles (EVs) are produced and released by most cells and are now recognized to play a role in intercellular communication through the delivery of molecular cargo, including proteins, lipids, and RNA. Small RNA sequencing (small RNA-seq) has been widely used to characterize the small RNA content in EVs. However, there is a lack of a systematic assessment of the quality, technical biases, RNA composition, and RNA biotypes enrichment for small RNA profiling of EVs across cell types, biofluids, and conditions. Methods: We collected and reanalyzed small RNA-seq datasets for 2756 samples from 83 studies involving 55 with EVs only and 28 with both EVs and matched donor cells. We assessed their quality by the total number of reads after adapter trimming, the overall alignment rate to the host and non-host genomes, and the proportional abundance of total small RNA and specific biotypes, such as miRNA, tRNA, rRNA, and Y RNA. Results: We found that EV extraction methods varied in their reproducibility in isolating small RNAs, with effects on small RNA composition. Comparing proportional abundances of RNA biotypes between EVs and matched donor cells, we discovered that rRNA and tRNA fragments were relatively enriched, but miRNAs and snoRNA were depleted in EVs. Except for the export of eight miRNAs being context-independent, the selective release of most miRNAs into EVs was study-specific. Conclusion: This work guides quality control and the selection of EV isolation methods and enhances the interpretation of small RNA contents and preferential loading in EVs.

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Section: Resultsmentioning

confidence: 99%

Systematic Assessment of Small RNA Profiling in Human Extracellular Vesicles

Wang,

Chen,

Sheng

et al. 2023

Cancers

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“…This list of 92 cnvd -miRNAs was an assortment of novel predictive candidates and acknowledged markers of radiation and cancer. For instance, miR-24-1-5p 64 , miR-30e-3p 65 , miR-28-5p 66 , miR-142-3p 67 , miR-148a-5p 68 , miR-455-3p 69 , miR-139-3p 70 , miR-1306-5p 71 and several others mentioned in Table 1 were linked to various radiation and carcinogenesis studies. On the other hand, there are some candidates in the list of 92 cnvd -miRNAs, such as miR-30a-3p and miR-199b-5p, which had not previously linked to minipig radiation model.…”

Section: Discussionmentioning

confidence: 99%

Early to sustained impacts of lethal radiation on circulating miRNAs in a minipig model

Chakraborty,

Holmes-Hampton,

Gautam

et al. 2023

Sci Rep

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Early diagnosis of lethal radiation is imperative since its intervention time windows are considerably short. Hence, ideal diagnostic candidates of radiation should be easily accessible, enable to inform about the stress history and objectively triage subjects in a time-efficient manner. Therefore, the small molecules such as metabolites and microRNAs (miRNAs) from plasma are legitimate biomarker candidate for lethal radiation. Our objectives were to comprehend the radiation-driven molecular pathogenesis and thereby determine biomarkers of translational potential. We investigated an established minipig model of LD70/45 total body irradiation (TBI). In this pilot study, plasma was collected pre-TBI and at multiple time points post-TBI. The majority of differentially expressed miRNAs and metabolites were perturbed immediately after TBI that potentially underlined the severity of its acute impact. The integrative network analysis of miRNA and metabolites showed a cohesive response; the early and consistent perturbations of networks were linked to cancer and the shift in musculoskeletal atrophy synchronized with the comorbidity-networks associated with inflammation and bioenergy synthesis. Subsequent comparative pipeline delivered 92 miRNAs, which demonstrated sequential homology between human and minipig, and potentially similar responses to lethal radiation across these two species. This panel promised to retrospectively inform the time since the radiation occurred; thereby could facilitate knowledge-driven interventions.

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“…Upregulating miR-373-3p triggers apoptosis in liver cancer cells by downregulating AKT and TFAP4, which is reversed by TFAP4 overexpression [ 51 ]. miR-1306-5p is downregulated in colon cancer cells and tissues [ 53 ]. miR-1306-5p targets solute carrier organic anion transporter family member 2A1 ( SLCO2A1 ).…”

Section: Relationship Between Mirna Akt and Cell Functionsmentioning

confidence: 99%

“…Overexpressing miR-1306-5p suppresses AKT signaling. Overexpressing miR-1306-5p inhibits proliferation and enhances apoptosis in colon cancer cells by inactivating AKT and targeting SLCO2A1 [ 53 ].…”

Section: Relationship Between Mirna Akt and Cell Functionsmentioning

confidence: 99%

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Modulation of AKT Pathway-Targeting miRNAs for Cancer Cell Treatment with Natural Products

Shiau

Chuang

Yen

et al. 2023

IJMS

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Many miRNAs are known to target the AKT serine-threonine kinase (AKT) pathway, which is critical for the regulation of several cell functions in cancer cell development. Many natural products exhibiting anticancer effects have been reported, but their connections to the AKT pathway (AKT and its effectors) and miRNAs have rarely been investigated. This review aimed to demarcate the relationship between miRNAs and the AKT pathway during the regulation of cancer cell functions by natural products. Identifying the connections between miRNAs and the AKT pathway and between miRNAs and natural products made it possible to establish an miRNA/AKT/natural product axis to facilitate a better understanding of their anticancer mechanisms. Moreover, the miRNA database (miRDB) was used to retrieve more AKT pathway-related target candidates for miRNAs. By evaluating the reported facts, the cell functions of these database-generated candidates were connected to natural products. Therefore, this review provides a comprehensive overview of the natural product/miRNA/AKT pathway in the modulation of cancer cell development.

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MiR-1306-5p predicts favorable prognosis and inhibits proliferation, migration, and invasion of colorectal cancer cells via PI3K/AKT/mTOR pathway

Cited by 6 publications

References 23 publications

Systematic Assessment of Small RNA Profiling in Human Extracellular Vesicles

Systematic Assessment of Small RNA Profiling in Human Extracellular Vesicles

Early to sustained impacts of lethal radiation on circulating miRNAs in a minipig model

Modulation of AKT Pathway-Targeting miRNAs for Cancer Cell Treatment with Natural Products

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