MiR-1297 and MiR-26a-5p Inhibit Cell Progression of Keratinocytes in Cholesteatoma Depending on the Regulation of BMI1

Zhu, Xiaodan; Ye, Fanglei; Hao, Shaojuan; Yu, Qiuning; Wang, Yan; Lou, Weihua; Zhao, Kun; Li, Hongmin

doi:10.1007/s12257-021-0178-y

Cited by 1 publication

(7 citation statements)

References 33 publications

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“…In total, 118 articles were retrieved through the database search. After applying the search strategy described above, a total of 18 articles were identified that met all inclusion criteria [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47]. A flow diagram of the detailed study selection process is presented in Figure 1.…”

Section: Search Results Study Characteristics and Study Qualitymentioning

confidence: 99%

“…All included studies used cholesteatoma tissues for analysis. Additionally, the majority of studies included in vitro experiments on cell lines [30,32,[34][35][36][37][38][39][42][43][44]46,47]. In the Zheng study [46], a mouse model was also used for in vivo testing.…”

Section: Search Results Study Characteristics and Study Qualitymentioning

confidence: 99%

“…[41] miR-10a-5p downregulated Zhu, X. [47] miR-1297, miR-26a-5p downregulated Zang, J. [44] miR-125b downregulated Table 3.…”

Section: Study Mirna Expression In Cholesteatoma Tissuementioning

confidence: 99%

“…However, the included studies provided new information on the role of miR-1297 and miR-26a-5p concerning the pathogenesis of cholesteatoma. miR-1297 and miR-26a-5p were shown to inhibit the progression of cholesteatoma keratinocytes by targeting the B-cell-specific Moloney murine leukemia virus insertion site 1 (BMI1) [47]. BMI1 is a component of the polycomb 70 repressive complex 1, which is a transcriptional repressor that increases cell survival [127].…”

Section: Microrna-802mentioning

confidence: 99%

“…A significantly elevated mRNA expression of BMI1 and protein level of BMI1 were demonstrated in cholesteatoma tumor tissues relative to normal retroauricular skin specimens [43,47]. The downregulation of BMI1 was shown to significantly inhibit the proliferation of human immortalized keratinocytes, indicating a pro-oncogenic role for BMI1 in cholesteatomas, which is consistent with observations in other malignant entities [47]. The prediction result obtained with DianaTools software showed that BMI1 directly interacts with miR-1297 and miR-26a-5p in human immortalized keratinocytes.…”

Section: Microrna-802mentioning

confidence: 99%

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Expression and Regulatory Mechanisms of MicroRNA in Cholesteatoma: A Systematic Review

Dżaman,

Czerwaty,

Reichert

et al. 2023

IJMS

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Cholesteatoma is a temporal bone disease characterized by dysfunctions of keratinocytes. MicroRNAs (miRNAs) are evolutionary conserved noncoding RNAs that regulate mRNA expression. They can be packaged into exosomes and transported to target cells that can be used in the future therapy of cholesteatoma. This study aimed to collect knowledge on the role of miRNAs and exosomal miRNAs in cholesteatoma and was conducted according to the PRISMA guidelines for systematic reviews. Four databases were screened: Pubmed/MEDLINE, Web of Science, Scopus, and the Cochrane Library. The last search was run on the 6th of June 2023. We included full-text original studies written in English, which examined miRNAs in cholesteatoma. The risk of bias was assessed using the Office of Health Assessment and Translation (OHAT) Risk of Bias Rating Tool, modified for the needs of this review. We identified 118 records and included 18 articles. Analyses revealed the downregulation of exosomal miR-17 as well as miR-10a-5p, miR-125b, miR-142-5p, miR34a, miR-203a, and miR-152-5p and the overexpression of exosomal miR-106b-5p as well as miR-1297, miR-26a-5p, miR-199a, miR-508-3p, miR-21-3p, miR-584-5p, and miR-16-1-3p in cholesteatoma. The role of differentially expressed miRNAs in cholesteatoma, including cell proliferation, apoptosis, the cell cycle, differentiation, bone resorption, and the remodeling process, was confirmed, making them a potential therapeutic target in this disease.

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