MiR-1281 is involved in depression disorder and the antidepressant effects of Kai-Xin-San by targeting ADCY1 and DVL1

Chen, Chao; Xu, Yuan-jie; Zhang, Shang-rong; Wang, Xiaohui; Hu, Yuan; Guo, Dai-Hong; Zhou, Xiaojiang; Zhu, Wenhe; Wen, Aidong; Tan, Qingrong; Dong, Xian‐Zhe; Liu, Ping

doi:10.1016/j.heliyon.2023.e14265

Cited by 3 publications

(2 citation statements)

References 71 publications

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“…Recently, Chao Chen et al discovered that MiR-1281 contributes to depression disorder and the antidepressant effects of Kai-Xin-San (a Chinese medicine formulation). This finding also suggests that Chinese medicine influences the application of ncRNAs in depression treatment [ 160 ].…”

Section: Ncrnas’ Potential In the Clinical Treatment Of Depressionmentioning

confidence: 97%

The role of ncRNAs in depression

Luan,

Xing,

Guo

et al. 2024

Heliyon

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Section: Ncrnas’ Potential In the Clinical Treatment Of Depressionmentioning

confidence: 97%

The role of ncRNAs in depression

Luan,

Xing,

Guo

et al. 2024

Heliyon

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“…The KXS trial demonstrated positive results in depression treatment[ 73 ]. The information provided by Chen et al [ 74 ] leads one to believe that miR-1281 targets ADCY1 and DVL1. The results indicate a novel link between miR-1281 and depression based on the in vivo identification of miRNA expression profiles.…”

Section: Overview Of Tcmmentioning

confidence: 99%

Exploring the transformative impact of traditional Chinese medicine on depression: Insights from animal models

Yang,

Chen,

Xie

2024

World J Psychiatry

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Depression, a prevalent and complex mental health condition, presents a significant global health burden. Depression is one of the most frequent mental disorders; deaths from it account for 14.3% of people worldwide. In recent years, the integration of complementary and alternative medicine, including traditional Chinese medicine (TCM), has gained attention as a potential avenue for addressing depression. This comprehensive review critically assesses the efficacy of TCM interventions in alleviating depressive symptoms. An in-depth look at different research studies, clinical trials, and meta-analyses is used in this review to look into how TCM practices like herbal formulations, acupuncture, and mind-body practices work. The review looks at the quality of the evidence, the rigor of the methods, and any possible flaws in the current studies. This gives us an idea of where TCM stands right now in terms of treating depression. This comprehensive review aims to assess the efficacy of TCM interventions in alleviating depressive symptoms. In order to learn more about their possible healing effects, the study also looks into how different types of TCM work, such as herbal formulas, acupuncture, and mind-body practices.

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Signals of selection and ancestry in independently feral Gallus gallus populations

Gering,

Johnsson,

Theunissen

et al. 2024

Molecular Ecology

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Recent work indicates that feralisation is not a simple reversal of domestication, and therefore raises questions about the predictability of evolution across replicated feral populations. In the present study we compare genes and traits of two independently established feral populations of chickens (Gallus gallus) that inhabit archipelagos within the Pacific and Atlantic regions to test for evolutionary parallelism and/or divergence. We find that feral populations from each region are genetically closer to one another than other domestic breeds, despite their geographical isolation and divergent colonisation histories. Next, we used genome scans to identify genomic regions selected during feralisation (selective sweeps) in two independently feral populations from Bermuda and Hawaii. Three selective sweep regions (each identified by multiple detection methods) were shared between feral populations, and this overlap is inconsistent with a null model in which selection targets are randomly distributed throughout the genome. In the case of the Bermudian population, many of the genes present within the selective sweeps were either not annotated or of unknown function. Of the nine genes that were identifiable, five were related to behaviour, with the remaining genes involved in bone metabolism, eye development and the immune system. Our findings suggest that a subset of feralisation loci (i.e. genomic targets of recent selection in feral populations) are shared across independently established populations, raising the possibility that feralisation involves some degree of parallelism or convergence and the potential for a shared feralisation ‘syndrome’.

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MiR-1281 is involved in depression disorder and the antidepressant effects of Kai-Xin-San by targeting ADCY1 and DVL1

Cited by 3 publications

References 71 publications

The role of ncRNAs in depression

The role of ncRNAs in depression

Exploring the transformative impact of traditional Chinese medicine on depression: Insights from animal models

Signals of selection and ancestry in independently feral Gallus gallus populations

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