miR-128 regulates differentiation of hair follicle mesenchymal stem cells into smooth muscle cells by targeting SMAD2

Wang, Wenwen; Pang, Li; Zhao, Hu; Song, Lei; Wang, Yuehui; Sun, Qi; Guo, Chunjie; Wang, Bin; Qin, Xiujiao; Pan, Aiqun

doi:10.1016/j.acthis.2016.04.001

Cited by 22 publications

(18 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yellow node represents circRNA, purple node represents miRNA. Edge denotes the relationship between circRNA and miRNA source genes of these circRNAs (AKT3, TGFBR1, SMAD2, SOS2, RB1, EZH1, and FGFR2) were reported to participate in the growth process of hair follicles [36][37][38][39][40][41][42][43]. Comparison between our results and those of previous studies suggests that the selected circRNAs might play an important role in the signaling pathways during different stages of SF development in AFWS.…”

Section: Discussionsupporting

confidence: 60%

Identification and characterization of circRNAs in the skin during wool follicle development in Aohan fine wool sheep

et al. 2020

View full text Add to dashboard Cite

Background: Aohan fine wool sheep (AFWS) is a historically bred fine wool sheep, cultivated in China. The wool has excellent quality and good textile performance. Investigating the molecular mechanisms that regulate wool growth is important to improve wool quality and yield. Circular RNAs (circRNAs) are widely expressed non-coding RNAs that can act as competitive endogenous RNAs (ceRNAs) to bind to miRNAs. Although circRNAs have been studied in many fields, research on their activity in sheep wool follicles is limited. To understand the regulation of circRNAs in the growth of fine wool in sheep, we used RNA-Seq to identify circRNAs in sheep shoulder skin samples at three developmental stages: embryonic day 90 (E90d), embryonic day 120 (E120d), and at birth (Birth). Results: We identified 8753 circRNAs and found that 918 were differentially-expressed. We then analyzed the classification and characteristic of the circRNAs in sheep shoulder skin. Using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), we identified the source genes of circRNAs, which were mainly enriched in cellular component organization, regulation of primary metabolic processes, tight junctions, and the cGMP-PKG and AMPK signaling pathways. In addition, we predicted interactions between 17 circRNAs and eight miRNAs, using miRanda software. Based on the significant pathways, we speculate that circ_0005720, circ_0001754, circ_0008036, circ_0004032, circ_0005174, circ_0005519, and circ_0007826 might play an important role in regulating wool follicle growth in AFWS. Seven circRNAs were randomly selected to validate the RNA-Seq results, using qRT-PCR. Conclusion: Our results provide more information about circRNAs regulation of wool follicle development in AFWS, and establish a solid foundation for future research.

show abstract

Section: Discussionsupporting

confidence: 60%

Identification and characterization of circRNAs in the skin during wool follicle development in Aohan fine wool sheep

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In our study, seven circRNAs (circ_0005720, circ_0001754, circ_0008036, circ_0004032, circ_0005174, circ_0005519, and circ_0007826) were identified based on the significant KEGG pathways. The source genes of these circRNAs (AKT3, TGFBR1, SMAD2, SOS2, RB1, EZH1, and FGFR2) were reported to participate in the growth process of hair follicles [36][37][38][39][40][41][42][43]. Comparison between our results and those of previous studies suggests that the selected circRNAs might play an important role in the signaling pathways during different stages of SF development in AFWS.…”

Section: Validation Of Circrnas Expression By Qrt-pcrsupporting

confidence: 57%

Identification and characterization of circRNAs in the skin during wool follicle development in Aohan fine wool sheep

Zhao

Liu

Han

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Aohan fine wool sheep (AFWS) is a historically bred fine wool sheep, cultivated in China. The wool has excellent quality and good textile performance. Investigating the molecular mechanisms that regulate wool growth is important to improve wool quality and yield. Circular RNAs (circRNAs) are non-coding RNAs that are widely expressed, and can act as a competitive endogenous RNAs (ceRNAs) to bind to miRNAs. Although circRNAs have been studied in many fields, research on their activity in sheep wool follicles is limited. To understand the regulation of circRNAs in the growth of fine wool in sheep, we used RNA-seq to identify circRNAs in sheep shoulder skin samples at three developmental stages: embryonic day 90 (E90d), embryonic day 120 (E120d), and at birth (Birth). Results: We identified 8,753 circRNAs and found that 918 were differentially-expressed. We then analyzed the classification and characteristic of the circRNAs in sheep shoulder skin. Using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), we identified the source genes of circRNAs, which were mainly enriched in cellular component organization, regulation of primary metabolic processes, tight junctions, and the cGMP-PKG and AMPK signaling pathways. In addition, we predict interactions between 17 circRNAs and eight miRNAs, using miRanda software. Based on the significant pathways, we speculate that circ_0005720, circ_0001754, circ_0008036, circ_0004032, circ_0005174, circ_0005519, circ_0007826 might play an important role in regulating wool follicle growth in AFWS. Seven circRNAs were randomly selected, and have validated the results of the RNA-seq by qRT-PCR. Conclusion: Our results provide more information about circRNAs in regulating wool follicle development in AFWS, and establish a solid foundation for future research.

show abstract

“…In our study, seven circRNAs (circ_0005720, circ_0001754, circ_0008036, circ_0004032, circ_0005174, circ_0005519, and circ_0007826) were identified based on the significant KEGG pathways, and the source genes of these circRNAs (AKT3, TGFBR1, SMAD2, SOS2, RB1, EZH1, and FGFR2) have been reported to participate in the growth process of hair follicles [36][37][38][39][40][41][42][43]. Comparing these results with those of previous studies, the selected circRNAs might play an important role in the signaling pathways during different stages of secondary wool follicle development in AFWS.…”

Section: Discussionmentioning

confidence: 92%

Identification and characterization of circRNAs in the skin during wool follicle development in Aohan fine wool sheep

Zhao

Liu

Han

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Aohan fine wool sheep (AFWS) is a historically bred fine wool sheep, cultivated in China. The wool has excellent quality and good textile performance. Investigating the molecular mechanisms that regulate wool growth is important to improve wool quality and yield. Circular RNAs (circRNAs) are non-coding RNAs that are widely expressed, and can act as a competitive endogenous RNAs (ceRNAs) to bind to miRNAs. Although circRNAs have been studied in many fields, research on their activity in sheep wool follicles is limited. To understand the regulation of circRNAs in the growth of fine wool in sheep, we used RNA-seq to identify circRNAs in sheep shoulder skin samples at three developmental stages: embryonic day 90 (E90d), embryonic day 120 (E120d), and at birth (Birth). Results: We identified 8,753 circRNAs and found that 918 were differentially-expressed. We then analyzed the classification and characteristic of the circRNAs in sheep shoulder skin. Using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), we identified the source genes of circRNAs, which were mainly enriched in cellular component organization, regulation of primary metabolic processes, tight junctions, and the cGMP-PKG and AMPK signaling pathways. In addition, we predict interactions between 17 circRNAs and eight miRNAs, using miRanda software. Based on the significant pathways, we speculate that circ_0005720, circ_0001754, circ_0008036, circ_0004032, circ_0005174, circ_0005519, circ_0007826 might play an important role in regulating wool follicle growth in AFWS. Seven circRNAs were randomly selected, and have validated the results of the RNA-seq by qRT-PCR. Conclusion: Our results provide more information about circRNAs in regulating wool follicle development in AFWS, and establish a solid foundation for future research.

show abstract

miR-128 regulates differentiation of hair follicle mesenchymal stem cells into smooth muscle cells by targeting SMAD2

Cited by 22 publications

References 48 publications

Identification and characterization of circRNAs in the skin during wool follicle development in Aohan fine wool sheep

Identification and characterization of circRNAs in the skin during wool follicle development in Aohan fine wool sheep

Identification and characterization of circRNAs in the skin during wool follicle development in Aohan fine wool sheep

Identification and characterization of circRNAs in the skin during wool follicle development in Aohan fine wool sheep

Contact Info

Product

Resources

About