MiR-124 aggravates failing hearts by suppressing CD151-facilitated angiogenesis in heart

Zhang, Yanru; Yan, Mengwen; Chen, Chen; Gong, Wei; Yin, Zongsheng; Li, Huaping; Fan, Jiahui; Zhang, Xin A.; Wang, Dao Wen; Zuo, Houjuan

doi:10.18632/oncotarget.24205

Cited by 35 publications

(19 citation statements)

References 59 publications

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“…A study by Zhao et al, has shown that miR-124 can inhibit viability, promote apoptosis, and impair migration in human endothelial cells [25]. The miR-124 targets are key pro-survival genes, including SphK1 (sphingosine kinase1) [26,27] CDK6, ROCK1 [20][21][22][23], and STAT3 (signal transducers and activators of transcription 3) [28].…”

Section: Discussionmentioning

confidence: 99%

Circular RNA HIPK3 downregulation mediates hydrogen peroxide-induced cytotoxicity in human osteoblasts

Liang

Shen

Zhang

et al. 2020

Aging

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Hydrogen peroxide (H2O2) induces oxidative injury to human osteoblasts. The expression and potential function of circular RNA HIPK3 (circHIPK3) in H2O2-treated human osteoblasts were tested. We show that H2O2 significantly downregulated circHIPK3 in OB-6 cells and primary human osteoblasts. Furthermore, circHIPK3 levels were decreased in the necrotic femoral head tissues of dexamethasone-treated patients. In OB-6 osteoblastic cells and primary human osteoblasts, forced overexpression of circHIPK3 by a lentiviral construct alleviated H2O2-induced viability reduction, cell death and apoptosis. Contrarily, circHIPK3 silencing by targeted shRNA potentiated H2O2-induced cytotoxicity in OB-6 cells and primary human osteoblasts. Moreover, circHIPK3 downregulation by H2O2 induced miR-124 accumulation in OB-6 cells and primary human osteoblasts. On the contrary, miR-124 inhibition by transfection of the miR-124 inhibitor protected human osteoblasts from H2O2. Importantly, forced overexpression of miR-124 by transfection of the miR-124 mimic induced significant cytotoxicity in OB-6 cells and primary human osteoblasts. H2O2 downregulated miR-124's targets, cyclin dependent kinase 6 and Rho-Associated Protein Kinase 1, in human osteoblasts. In conclusion circHIPK3 downregulation mediates H2O2-induced cytotoxicity in human osteoblasts.

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Section: Discussionmentioning

confidence: 99%

Circular RNA HIPK3 downregulation mediates hydrogen peroxide-induced cytotoxicity in human osteoblasts

Liang

Shen

Zhang

et al. 2020

Aging

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“…MiR-124-3p was identified by us as regulating the highest number of genes in hiPSC-CMs. Literature data show its aggravating role in failing hearts by suppressing CD151-facilitated angiogenesis in the heart [110]. miR-124-3p dysregulates NSC maintenance through repression of the transferrin receptor (TFRC) in Zika virus infection [111].…”

Section: Discussionmentioning

confidence: 99%

ACE2 interaction networks in COVID-19: a physiological framework for prediction of outcome in patients with cardiovascular risk factors

Wicik

Eyileten

Jakubik

et al. 2020

Preprint

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Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease 2019; is associated with adverse outcome in patients with cardiovascular disease (CVD).Aim: To characterize the interaction between SARS-CoV-2 and Angiotensin Converting Enzyme 2 (ACE2) functional networks with focus on CVD.Methods: Using bioinformatic tools, network medicine approaches and publicly available datasets, we investigated ACE2 tissue expression and described ACE2 interaction network which could be affected by SARS-CoV-2 infection. We identified top ACE2 interactors, including miRNAs which are shared regulators between the ACE2, virus-infection related proteins and heart interaction networks, using lung and nervous system networks as a reference. We also identified main SARS-CoV-2 risk groups and performed drug predictions for them.Results: We found the same range of ACE2 expression confidence in respiratory and cardiovascular systems (averaging 4.48 and 4.64, respectively). Analysing the complete ACE2 interaction network, we identified 11 genes (ACE2, DPP4, ANPEP, CCL2, TFRC, MEP1A, ADAM17, FABP2, NPC1, CLEC4M, TMPRSS2) associated with virus-infection related processes. Previously described genes associated with cardiovascular risk factors DPP4, CCL2 and ANPEP were extensively connected with top regulators of ACE2 network, including ACE, INS and KNG1. Enrichment analysis revealed several disease phenotypes associated with interaction networks of ACE2, heart tissue, and virus-infection related protein, with the strongest associations with the following diseases (in decreasing rank order): obesity, hypertensive disease, noninsulin dependent diabetes mellitus, congestive heart failure, and coronary artery disease. We described for the first time microRNAs-miR (miR-302c-5p, miR-1305, miR-587, miR-26b-5p, and mir-27a-3p), which were common regulators of the three networks: ACE2, heart tissue and virus-infection related proteins.Conclusion: Our study provides novel information regarding the complexity of signaling pathways affected by SARS-CoV-2 and proposes predictive tools as miR towards personalized diagnosis and therapy in COVID-19. Additionally, our study provides a list of miRNAs with biomarker potential in prediction of adverse outcome in patients with COVID-19 and CVD.

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“…Therefore, miR-133b has roles both in the brain and the heart. Another example is miR-124, along with miR-124-5p and miR-124-3p, which are known for their protective roles in cardiac injury, angiogenesis, and other heart diseases [180,181]. In addition, miR-124-3p is an efficient prognostication tool for neurological outcome and survival in patients post-cardiac arrest [59].…”

Section: Non-coding Rnas In the Brain-heart Axis In Pdmentioning

confidence: 99%

Non-Coding RNAs in the Brain-Heart Axis: The Case of Parkinson’s Disease

Acharya

Salgado-Somoza

Stefanizzi

et al. 2020

IJMS

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Parkinson’s disease (PD) is a complex and heterogeneous disorder involving multiple genetic and environmental influences. Although a wide range of PD risk factors and clinical markers for the symptomatic motor stage of the disease have been identified, there are still no reliable biomarkers available for the early pre-motor phase of PD and for predicting disease progression. High-throughput RNA-based biomarker profiling and modeling may provide a means to exploit the joint information content from a multitude of markers to derive diagnostic and prognostic signatures. In the field of PD biomarker research, currently, no clinically validated RNA-based biomarker models are available, but previous studies reported several significantly disease-associated changes in RNA abundances and activities in multiple human tissues and body fluids. Here, we review the current knowledge of the regulation and function of non-coding RNAs in PD, focusing on microRNAs, long non-coding RNAs, and circular RNAs. Since there is growing evidence for functional interactions between the heart and the brain, we discuss the benefits of studying the role of non-coding RNAs in organ interactions when deciphering the complex regulatory networks involved in PD progression. We finally review important concepts of harmonization and curation of high throughput datasets, and we discuss the potential of systems biomedicine to derive and evaluate RNA biomarker signatures from high-throughput expression data.

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MiR-124 aggravates failing hearts by suppressing CD151-facilitated angiogenesis in heart

Cited by 35 publications

References 59 publications

Circular RNA HIPK3 downregulation mediates hydrogen peroxide-induced cytotoxicity in human osteoblasts

Circular RNA HIPK3 downregulation mediates hydrogen peroxide-induced cytotoxicity in human osteoblasts

ACE2 interaction networks in COVID-19: a physiological framework for prediction of outcome in patients with cardiovascular risk factors

Non-Coding RNAs in the Brain-Heart Axis: The Case of Parkinson’s Disease

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