miR-122 regulates hepatic lipid metabolism and tumor suppression

Complexity of microRNA function and the role of isomiRs in lipid homeostasis

“…As such, miR-122 is the most studied hepatic miRNA and is directly involved in hepatitis C infection ( 127,128 ), cellular proliferation ( 129,130 ), differentiation ( 102 ), and tumor suppression ( 131 ). miR-122 is also a critical regulator of hepatic lipid metabolism and systemic lipid homeostasis ( 40,(132)(133)(134). miR-122 is thought to be transcribed only in hepatocytes; however, miR-122 is present in extracellular fl uids ( 135,136 ), including plasma, and may be transferred to other cells by extracellular RNA carriers ( 137 ).…”

Comprehensive identification and profiling of host miRNAs in response to Singapore grouper iridovirus (SGIV) infection in grouper (Epinephelus coioides)

“…For example, miR-138, which is highly conserved between human and grouper, was found to be related to cell proliferation in both species (Supplementary File S6) (Ye et al, 2015). Besides, miR-122, with 100% sequence identical in all vertebrates mentioned earlier, was found to be involved in inflammatory response in both grouper and mouse (Supplementary File S6) (Wen and Friedman, 2012).…”

Identification of miR-423 and miR-499 Polymorphisms on Affecting the Risk of Hepatocellular Carcinoma in a Large-Scale Population

“…Several miRNAs that either suppress or promote tumor formation have been identified (Croce, 2009). Aberrant expression of miRNAs in liver often results in cancer development, such as miR-125b and miR-122 (Liang et al, 2010;Wen and Friedman, 2012). It is reported that miR-125b could suppress liver cancer cell growth, migration, and invasion (Liang et al, 2010).…”