miR-1204 targets VDR to promotes epithelial-mesenchymal transition and metastasis in breast cancer

Liu, Xiaoyan; Bi, Lei; Wang, Qin; Wen, Mingxin; Li, Ce; Ren, Yidan; Jiao, Qinlian; Mao, Jian‐Hua; Wang, Chuanxin; Wei, Guangwei; Wang, Yunshan

doi:10.1038/s41388-018-0215-2

Cited by 52 publications

(56 citation statements)

References 35 publications

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“…miRNAs have the ability to be reliable predictors of cancer biomarkers and therapeutic responses (Berindan‐Neagoe et al, ). It was found in previous study that miR‐1204 may promote epithelial–mesenchymal transition and metastasis in breast cancer by regulating VDR (Liu et al, ). Nevertheless, the molecular mechanism of miR‐1204 in NSCLC is still unknown.…”

Section: Discussionmentioning

confidence: 94%

“…The current study found that miR‐1204, a member of the PVT1 locus, may play a part in B cell differentiation because the level of primary miR‐1204 increased at the same time (Huppi et al, ). miR‐1204 was reported to promote epithelial–mesenchymal transition and metastasis in breast cancer by targeting VDR (Liu et al, ). However, the potential carcinogenicity and underlying mechanism of miR‐1204 in human NSCLC remain unclear.…”

Section: Introductionmentioning

confidence: 99%

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MicroRNA‐1204 promotes cell proliferation by regulating PITX1 in non‐small‐cell lung cancer

Jiang

Shi

et al. 2019

Cell Biology International

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MicroRNA‐1204 (miR‐1204), a member of the PVT1 region, may improve B cell differentiation and metastasis in breast cancer. However, the role of miR‐1204 in non‐small‐cell lung cancer (NSCLC) and its mechanism remain unclear. The GEO public database was first employed to find differentially expressed genes. The expression level of miR‐1204 in patient tissues and NSCLC cell lines was determined using qRT‐PCR. Cell proliferation assays were performed to investigate the impact of miR‐1204 on cell growth. Bioinformatics analysis and dual‐luciferase reporter assays were conducted to find potential target genes. Finally, we performed in vivo experiments to identify the effect of miR‐1204 on tumor formation in nude mice. It was first found that miR‐1204 was overexpressed in NSCLC tissues and cells. miR‐1204 increased the proliferation of NSCLC cells and reduced cell cycle arrest in vitro. PITX1 (paired like homeodomain 1) was found as a potential target gene. In addition, PITX1 was also found to be low in expression in NSCLC tissues and cells. To show that PITX1 reversed the function of miR‐1204 in promoting proliferation, confirmatory experiments were performed. Moreover, high miR‐1204 and low PITX1 expression was highly correlated with tumor size, lymph node metastasis, and the TNM stage in patients diagnosed with NSCLC. Our results suggested that upregulated miR‐1204 in NSCLC is associated with NSCLC progression and promotes NSCLC cell proliferation by downregulating PITX1. miR‐1204 may act as a poor prognostic factor and a potential therapeutic target for NSCLC.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

MicroRNA‐1204 promotes cell proliferation by regulating PITX1 in non‐small‐cell lung cancer

Jiang

Shi

et al. 2019

Cell Biology International

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“…While, the adipocytokine signaling pathway was enriched and predicted to be linked to the expression of multiple genes associated with super-enhancers in the MCF-7 model, STAT3 was not predicted to be associated with any of the super-enhancers in MCF7 compared to the MDA-MB-468 triple negative model; STAT3 was associated with all. Among the top scoring genes associated with the network pathway analysis in MDA-MB-468, unsurprisingly, most genes were associated with promotion of invasion, survival and aggressiveness [205][206][207][208][209][210][211][212][213] relative to those associated with the entire pathway activation in MCF-7 associated with inhibition of tumour suppression and [214,215], promotion of tumourigenesis, migration and survival [216][217][218][219][220][221][222][223]. Comparative downstream pathway analysis of the effect of the adipocytokine pathway in breast cancer using the SEanalysis web tool [224,225] for super enhancer associated regulatory analysis.…”

Section: Adipose Tissue: An Inflammatory Macroenvironment Stimulatingmentioning

confidence: 99%

“…relative to those associated with the entire pathway activation in MCF-7 associated with inhibition of tumour suppression and[214,215], promotion of tumourigenesis, migration and survival[216][217][218][219][220][221][222][223].…”

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confidence: 99%

A STAT3 of Addiction: Adipose Tissue, Adipocytokine Signalling and STAT3 as Mediators of Metabolic Remodelling in the Tumour Microenvironment

Kadye

Stoffels

Fanucci

et al. 2020

Cells

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Metabolic remodelling of the tumour microenvironment is a major mechanism by which cancer cells survive and resist treatment. The pro-oncogenic inflammatory cascade released by adipose tissue promotes oncogenic transformation, proliferation, angiogenesis, metastasis and evasion of apoptosis. STAT3 has emerged as an important mediator of metabolic remodelling. As a downstream effector of adipocytokines and cytokines, its canonical and non-canonical activities affect mitochondrial functioning and cancer metabolism. In this review, we examine the central role played by the crosstalk between the transcriptional and mitochondrial roles of STAT3 to promote survival and further oncogenesis within the tumour microenvironment with a particular focus on adipose-breast cancer interactions.

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“…As a result, a total of 12 miRNAs were found to be embedded in genomic regions of seven lncRNAs (). Through comprehensive literature annotation for these miRNAs and lncRNAs, we found that two lncRNAs ( PVT1 and MIR31HG ) and the embedded five miRNAs ( hsa‐mir‐1204 , hsa‐mir‐1205 , hsa‐mir‐1206 , hsa‐mir‐1207 ; hsa‐mir‐31 ) play oncogenic roles that were widely confirmed by previous studies (Guan et al ., ; Kong et al ., ; Liu et al ., ; Shih et al ., ; Valastyan et al ., ; Wu et al ., 2018b; Yamagishi et al ., ; Yan et al ., ). These findings suggest that both of these lncRNAs and derived miRNAs contribute to tumorigenesis, although, for lncRNAs LINC00969 , U47924.29 and LINC00669 , we did not find evidence of oncogenic roles recorded in literature.…”

Section: Discussionmentioning

confidence: 98%

A pan‐cancer atlas of cancer hallmark‐associated candidate driver lncRNAs

et al. 2018

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Substantial cancer genome sequencing efforts have discovered many important driver genes contributing to tumorigenesis. However, very little is known about the genetic alterations of long non‐coding RNAs (lncRNAs) in cancer. Thus, there is a need for systematic surveys of driver lncRNAs. Through integrative analysis of 5918 tumors across 11 cancer types, we revealed that lncRNAs have undergone dramatic genomic alterations, many of which are mutually exclusive with well‐known cancer genes. Using the hypothesis of functional redundancy of mutual exclusivity, we developed a computational framework to identify driver lncRNAs associated with different cancer hallmarks. Applying it to pan‐cancer data, we identified 378 candidate driver lncRNAs whose genomic features highly resemble the known cancer driver genes (e.g. high conservation and early replication). We further validated the candidate driver lncRNAs involved in ‘Tissue Invasion and Metastasis’ in lung adenocarcinoma and breast cancer, and also highlighted their potential roles in improving clinical outcomes. In summary, we have generated a comprehensive landscape of cancer candidate driver lncRNAs that could act as a starting point for future functional explorations, as well as the identification of biomarkers and lncRNA‐based target therapy.

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miR-1204 targets VDR to promotes epithelial-mesenchymal transition and metastasis in breast cancer

Cited by 52 publications

References 35 publications

MicroRNA‐1204 promotes cell proliferation by regulating PITX1 in non‐small‐cell lung cancer

MicroRNA‐1204 promotes cell proliferation by regulating PITX1 in non‐small‐cell lung cancer

A STAT3 of Addiction: Adipose Tissue, Adipocytokine Signalling and STAT3 as Mediators of Metabolic Remodelling in the Tumour Microenvironment

A pan‐cancer atlas of cancer hallmark‐associated candidate driver lncRNAs

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