MiR-1202 functions as a tumor suppressor in glioma cells by targeting Rab1A

Yu, Quan; Song, Qian; Wang, Jvbo; Zhao, Lingyu; Lv, Jian; Gong, Shengjie

doi:10.1177/1010428317697565

Cited by 27 publications

(18 citation statements)

References 40 publications

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“…In this study, miR-33b-3p and miR-940 were downregulated in the OA group, suggesting the potential role of them in OA. As a member of the miRNA family, miR-1202 suppresses proliferation and induces endoplasmic reticulum stress in tumor cells, which suggest a potential therapy of miR-1202 in clinical treatment [43]. Despite that, miR-1202 is a primate-specific and brainenriched miRNA [44].…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-1202 plays a vital role in osteoarthritis via KCNQ1OT1 has-miR-1202-ETS1 regulatory pathway

Liu

Gao

et al. 2020

J Orthop Surg Res

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Background: This study aimed to explore the molecular mechanism of osteoarthritis (OA) and provide information about new genes as potential targets for OA treatment. Methods: Gene expression profile of GSE105027, including 12 OA serum samples (OA group) and 12 healthy serum samples (ctrl group), was downloaded. The differentially expressed miRNAs (DEMs) as well as miRNA-mRNAs interactions were investigated, followed by function and pathway investigation. Then the protein-protein interaction (PPI) network was performed. Furthermore, the long non-coding RNA (lncRNA)-miRNA-mRNA interactions (competing endogenous RNAs, ceRNAs) were investigated. Results: A total of 17 downregulated miRNAs were revealed between OA and ctrl groups. These DEMs such as has-miR-1202 were mainly enriched in GO functions like histone acetyltransferase binding and KEGG pathways like cellular senescence. The integrated PPI network analysis showed that has-miR-1202, has-miR-33b-3p, has-miR-940, has-miR-4284, and has-miR-4281 were 5 downregulated miRNAs in this network. Furthermore, the lncRNA-miRNA-mRNA interactions such as KCNQ1OT1-has-miR-1202-ETS1 were revealed in the present ceRNA network. Conclusion: Key DEMs such as miR-33b-3p, miR-940, and miR-1202 may be involved in OA. miR-1202 may regulate OA development via histone acetyltransferase pathway binding function and cellular senescence pathway. Furthermore, KCNQ1OT1-has-miR-1202-ETS1 might be vital for the process of OA.

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Section: Discussionmentioning

confidence: 99%

MicroRNA-1202 plays a vital role in osteoarthritis via KCNQ1OT1 has-miR-1202-ETS1 regulatory pathway

Liu

Gao

et al. 2020

J Orthop Surg Res

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“…Nineteen of the downregulated miRNAs in chronic patients were found to be associated with carcinogenesis in various organs and tissues, such as miR-1207 [ 40 ], miR-3162-5p [ 41 , 42 ], miR-3196 [ 43 , 44 ], miR-371b-5p [ 45 ], miR-574-5p [ 46 , 47 ], miR-1225-5p [ 48 ], miR-4485 [ 49 ], miR-572 [ 50 ], miR-4299 [ 51 ], miR-3679-5p [ 52 ], miR-3940-5p [ 53 ], miR-638 [ 54 , 55 ], miR-1202 [ 56 ], miR-5787 [ 57 ], miR-1973 [ 58 ], miR-4532 [ 59 ], miR-1275 [ 60 ], miR-4728-5p [ 61 ], and miR-1915-3p [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

The microRNA expression signature of CD4+ T cells in the transition of brucellosis into chronicity

et al. 2018

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Brucellosis is a serious infectious disease that continues to be a significant cause of morbidity worldwide and across all ages. Despite early diagnosis and treatment, 10–30% of patients develop chronic brucellosis. Although there have been recent advances in our knowledge of Brucella virulence factors and hosts’ immune response to the infection, there is a lack of clear data regarding how the infection bypasses the immune system and becomes chronic. The present study investigated immunological factors and their roles in the transition of brucellosis from an acute to a chronic infection in CD4+ T cells. CD4+ T cells sorted from peripheral blood samples of patients with acute or chronic brucellosis and healthy controls using flow cytometry as well as more than 2000 miRNAs were screened using the GeneSpring GX (Agilent) 13.0 miRNA microarray software and were validated using reverse transcription polymerase chain reaction (RT-qPCR). Compared to acute cases, the expression levels of 28 miRNAs were significantly altered in chronic cases. Apart from one miRNA (miR-4649-3p), 27 miRNAs were not expressed in the acute cases (p <0.05, fold change> 2). According to KEGG pathway analysis, these miRNAs are involved in the regulation of target genes that were previously involved in the MAPK signalling pathway, regulation of the actin cytoskeleton, endocytosis, and protein processing in the endoplasmic reticulum. This indicates the potential role of these miRNAs in the development of chronic brucellosis. We suggest that these miRNAs can be used as markers to determine the transition of the disease into chronicity. This is the first study of miRNA expression that analyses human CD4+ T cells to clarify the mechanism of chronicity in brucellosis.

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“…MiRNA dysregulation is involved in tumor occurrence and progression by regulating numerous biological functions, such as cellular proliferation, cycle, differentiation, apoptosis, epithelial-mesenchymal transition (EMT), migration, invasion, metastasis, angiogenesis and chemoresistance (9,13,14). Increasing evidence has indicated that miRNAs act as oncogenes or tumour suppressors in tumorigenesis and tumor development by regulating corresponding target genes (15)(16)(17). Therefore, investigating the expression pattern and biological roles of miRNAs in CRC would provide novel and effective therapeutic targets for patients with this disease.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-760 inhibits cell proliferation and invasion of colorectal cancer by targeting the SP1-mediated PTEN/AKT signalling pathway

Ding

Liu

et al. 2017

Molecular Medicine Reports

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Colorectal cancer (CRC), one of the most commonly diagnosed types of cancer worldwide, is the third most prevalent and fourth most frequent cause of cancer‑related mortality. Dysregulated microRNAs (miRNAs) have potential regulatory roles in the development and progression of various cancer types. Therefore, the investigation of the miRNAs involved in CRC formation and progression may lead to the development of highly effective therapeutic strategies for CRC. In the present study, miRNA‑760 (miR‑760) was frequently downregulated in CRC tissues and cell lines. The low levels of miR‑760 expression were significantly correlated with the tumor size, lymph node metastasis and TNM stage of CRC. Functional assays revealed that restoring miR‑760 expression inhibited CRC cell proliferation and invasion in vitro. The results of bioinformatics analysis, luciferase reporter assay, reverse transcription‑quantitative polymerase chain reaction and western blot analysis suggested that specificity protein 1 (SP1) is a direct target of miR‑760 in CRC. The high expression of SP1 in CRC tissues was inversely correlated with the expression of miR‑760. Rescue experiments demonstrated that enforced SP1 expression rescued the tumor‑suppressing effects of miR‑760 on CRC cell proliferation and invasion. In addition, miR‑760 overexpression is involved in the regulation of the PTEN/AKT signalling pathway. Collectively, the present data demonstrated that miR‑760 directly targets SP1 to inactivate the PTEN/AKT signalling pathway, thus implicating miR‑760 in the regulation of CRC cell proliferation and invasion. Therefore, miR‑760 may be a novel biomarker and therapeutic target for CRC.

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MiR-1202 functions as a tumor suppressor in glioma cells by targeting Rab1A

Cited by 27 publications

References 40 publications

MicroRNA-1202 plays a vital role in osteoarthritis via KCNQ1OT1 has-miR-1202-ETS1 regulatory pathway

MicroRNA-1202 plays a vital role in osteoarthritis via KCNQ1OT1 has-miR-1202-ETS1 regulatory pathway

The microRNA expression signature of CD4+ T cells in the transition of brucellosis into chronicity

MicroRNA-760 inhibits cell proliferation and invasion of colorectal cancer by targeting the SP1-mediated PTEN/AKT signalling pathway

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