miR‑107‑5p promotes tumor proliferation and invasion by targeting estrogen receptor‑α in endometrial carcinoma

Bao, Wei; Zhang, Yan; Li, Shuangdi; Fan, Qiong; Qiu, Meiting; Wang, Yanan; Li, Yanli; Ji, Xiaoning; Yang, Ye; Sang, Zhenyu; Xu, Wei; Yang, Yongmei; Wu, Sufang; Zhu, Yue

doi:10.3892/or.2018.6936

Cited by 23 publications

(28 citation statements)

References 38 publications

(39 reference statements)

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“…293T cells (5x10 4 /well) were seeded into 24-well plates and transfected with 0.2 µg of either pGL3-ESR1/AR-3'UTR-WT or pGL3-ESR1/AR-3'UTR-MT. The luciferase reporter assay was performed as previously described ( 16 , 21 , 22 ).…”

Section: Methodsmentioning

confidence: 99%

“…The aberrant expression of miRNAs has been reported in various tumors ( 12 ), such as endometrial cancer ( 13 ), ovarian cancer ( 14 ), and CC ( 15 ). Our previous study demonstrated that miR-107-5p could promote tumor proliferation and invasion by targeting ERα in endometrial carcinoma ( 16 ); therefore, it was hypothesized that specific miRNAs may control ERα and AR expression post-transcriptionally during CC progression.…”

Section: Introductionmentioning

confidence: 99%

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miR‑130a‑3p promotes cell proliferation and invasion by targeting estrogen receptor α and androgen receptor in cervical cancer

et al. 2021

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Cervical cancer is the most common gynecological cancer in women worldwide. Human papillomavirus (HPV) is required but not sufficient for developing cervical cancer. HPV E6 and E7 proteins are able to directly interact with certain nuclear receptors; however, whether steroid hormone receptors mediate cervical carcinogenesis is not completely understood. The present study demonstrated via immunohistochemistry that estrogen receptor α (ERα) and androgen receptor (AR) expression were decreased in a sequential manner from healthy cervical tissues to cervical intraepithelial neoplasia tissues and further to cervical cancer (CC) tissues, whereas microRNA (miR)-130a-3p expression levels were higher in CC tissues compared with healthy tissues. Both ERα and AR were direct targets of miR-130a-3p, as determined by performing luciferase reporter assays and western blotting. Functionally, compared with the corresponding control groups, miR-130a-3p knockdown, ERα overexpression and AR overexpression significantly inhibited CC cell proliferation and invasion, as demonstrated by the results obtained from the Cell Counting Kit-8 and Transwell assays in vitro. In addition, antagomiR-130a decreased tumor size and weight in vivo compared with control antagomiR as determined via the xenograft tumor growth assay. Therefore, the results suggested that miR-130a-3p might contribute to tumor progression by suppressing ERα and AR, and serve as a promising candidate target for the treatment of patients with CC.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

miR‑130a‑3p promotes cell proliferation and invasion by targeting estrogen receptor α and androgen receptor in cervical cancer

et al. 2021

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“…Over the last 5 years, up to 754 miRNAs [ 17 ] have been identified as potential biomarkers in EC, some of which are correlated with lymph node involvement, advanced FIGO stage, metastatic status, or histologic type [ 17 , 40 , 103 , 118 , 161 , 162 ]. Increasing our knowledge of the miRNA expression status or the methylation state of key miRNA loci may help to better stratify patients.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA as Epigenetic Modifiers in Endometrial Cancer: A Systematic Review

Favier

Rocher

Larsen

et al. 2021

Cancers

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The objective of this systematic review is to summarize our current knowledge on the influence of miRNAs in the epigenetic deregulation of tumor-related genes in endometrial cancer (EC). We conducted a literature search on the role of miRNAs in the epigenetic regulation of EC applying the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The following terms were used: microRNA, miRNA, miR, endometrial cancer, endometrium, epigenetic, epimutation, hypermethylation, lynch, deacetylase, DICER, novel biomarker, histone, chromatin. The miRNAs were classified and are presented according to their function (tumor suppressor or onco-miRNA), their targets (when known), their expression levels in EC tissue vs the normal surrounding tissue, and the degree of DNA methylation in miRNA loci and CpG sites. Data were collected from 201 articles, including 190 original articles, published between November 1, 2008 and September 30, 2020 identifying 313 different miRNAs implicated in epigenetic regulation of EC. Overall, we identified a total of 148 miRNAs with decreased expression in EC, 140 miRNAs with increased expression in EC, and 22 miRNAs with discordant expression levels. The literature implicated different epigenetic phenomena including altered miRNA expression levels (miR-182, -230), changes in the methylation of miRNA loci (miR-34b, -129-2, -130a/b, -152, -200b, -625) and increased/decreased methylation of target genes (miR-30d,-191). This work provides an overview of all miRNAs reported to be involved in epigenetic regulation in EC including DNA methylation and RNA-associated silencing. These findings may contribute to novel strategies in diagnosis, risk assessment, and treatments aimed at miRNAs, their target genes or DNA methylation.

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“…Conversely, miR-203 suppresses the estrogen-induced viability, migration and invasion of ERα-positive breast cancer cells [68]. miR-107-5p has a direct interaction with ESR1 to enhance the proliferation and invasion of endometrial carcinomas [69]. On the other hand, miR-195 suppresses epithelial-mesenchymal transition by targeting G protein-coupled ESR1 in endometrial carcinomas [70].…”

Section: Mirnas and Er Function In Cancersmentioning

confidence: 99%

Perspectives on the Role of Non-Coding RNAs in the Regulation of Expression and Function of the Estrogen Receptor

Taheri

Shoorei

Dinger

et al. 2020

Cancers

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Estrogen receptors (ERs) comprise several nuclear and membrane-bound receptors with different tissue-specific functions. ERα and ERβ are two nuclear members of this family, whereas G protein-coupled estrogen receptor (GPER), ER-X, and Gq-coupled membrane estrogen receptor (Gq-mER) are membrane-bound G protein-coupled proteins. ERα participates in the development and function of several body organs such as the reproductive system, brain, heart and musculoskeletal systems. ERβ has a highly tissue-specific expression pattern, particularly in the female reproductive system, and exerts tumor-suppressive roles in some tissues. Recent studies have revealed functional links between both nuclear and membrane-bound ERs and non-coding RNAs. Several oncogenic lncRNAs and miRNAs have been shown to exert their effects through the modulation of the expression of ERs. Moreover, treatment with estradiol has been shown to alter the malignant behavior of cancer cells through functional axes composed of non-coding RNAs and ERs. The interaction between ERs and non-coding RNAs has functional relevance in several human pathologies associated with estrogen regulation, such as cancers, intervertebral disc degeneration, coronary heart disease and diabetes. In the current review, we summarize scientific literature on the role of miRNAs and lncRNAs on ER-associated signaling and related disorders.

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miR‑107‑5p promotes tumor proliferation and invasion by targeting estrogen receptor‑α in endometrial carcinoma

Cited by 23 publications

References 38 publications

miR‑130a‑3p promotes cell proliferation and invasion by targeting estrogen receptor α and androgen receptor in cervical cancer

miR‑130a‑3p promotes cell proliferation and invasion by targeting estrogen receptor α and androgen receptor in cervical cancer

MicroRNA as Epigenetic Modifiers in Endometrial Cancer: A Systematic Review

Perspectives on the Role of Non-Coding RNAs in the Regulation of Expression and Function of the Estrogen Receptor

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