Miocardiopatía alcohólica

Riba, Ramón Estruch

doi:10.1016/s0014-2565(01)70768-0

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…Alcoholic myocardiopathy is a type of non-ischemic dilated cardiomyopathy caused by long-term alcohol consumption ( 4 ). The mechanisms by which ethanol can induce cardiomyopathy include destruction of the integrity of myocardial cell membrane and effects on ion exchange and information transfer of various cardiac muscle cells; functional change of mitochondria and other organelles, leading to shortage of myocardial energy; abnormal fat deposition and changes of activity of ATP and inhibition of myocardial activity; imbalance of nutrition and aggravation of myocardial damages ( 5 – 7 ).…”

Section: Discussionmentioning

confidence: 99%

Clinical effects of carvedilol and trimetazidine for the treatmentof alcoholic myocardiopathy

Liu

et al. 2016

Experimental and Therapeutic Medicine

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The aim of the study was to compare the clinical effects of carvedilol and trimetazidine for the treatment of alcoholic cardiomyopathy. A total of 60 patients diagnosed with alcoholic cardiomyopathy were enrolled in the study. The patients were randomly divided into the carvedilol (n=20), trimetazidine (n=20) and control (n=20) groups. The patients in the control, carvedilol and trimetazidine groups were treated with conventional drugs, conventional drugs + carvedil and conventional drugs + trimetazidine respectively, for 12 weeks. The patients were compared for their heart functions [left ventricular ejection fraction (LVEF), C-reactive protein (CRP) and 6 min walking], heart rate, blood pressure and heart enlargement (cardiothoracic proportion and left ventricular diameter) before and after treatment. The parameters studied for heart functions, heart rate, blood pressure, heart enlargement, clinical effects before and after treatment were statistically insignificant (p>0.05). After treatment, the carvedilol and trimetazidine groups showed higher LVEF and CRP, longer walking distance in 6 min, as well as lower heart rate and blood pressure (both systolic and diastolic) compared to the control group. Similarly, the cardiothoracic proportion and left ventricular internal diameter for the carvedilol and trimetazidine groups was lower than those of the control group, with better clinical effects (p<0.05). In conclusion, the curative effects of the carvedilol and trimetazidine groups of alcoholic myocardiopathy similar. Both are safe agents that may improve the cardiac function and heart expansion of patients.

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Section: Discussionmentioning

confidence: 99%