Minoxidil topical treatment may be more efficient if applied on damp scalp in comparison with dry scalp

Ângelo, Tamara; Barbalho, Geisa N.; Gelfuso, Guilherme M.

doi:10.1111/dth.12369

Cited by 14 publications

(6 citation statements)

References 8 publications

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“…In vitro penetration was evaluated in intact and burnt porcine skin samples following a modified Saarbrücken method [27]. Briefly, quintuplicates of previously prepared porcine skin samples were used (5.7-cm 2 ).…”

Section: Skin Penetrationmentioning

confidence: 99%

Skin Regenerative Potential of Cupuaçu Seed Extract (Theobroma grandiflorum), a Native Fruit from the Amazon: Development of a Topical Formulation Based on Chitosan-Coated Nanocapsules

et al. 2022

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Scarless skin regeneration is a challenge in regenerative medicine. Herein, we explore the regenerative potential of a Cupuaçu seed extract (Theobroma grandiflorum) to develop an innovative skin regeneration formulation based on chitosan-coated nanocapsules. Cupuaçu seed extract significantly stimulated cell proliferation and migration. A reparative gene expression profile could be verified following extract treatment, which included high levels of MKI67, a cellular proliferation marker, and extracellular matrix genes, such as ELN and HAS2, which code for elastin and hyaluronic acid synthase 2. Formulations with Cupuaçu seed extract successfully entrapped into nanocapsules (EE% > 94%) were developed. Uncoated or coated nanocapsules with low-molecular-weight chitosan presented unimodal size distribution with hydrodynamic diameters of 278.3 ± 5.0 nm (PDI = 0.18 ± 0.02) and 337.2 ± 2.1 nm (PDI = 0.27 ± 0.01), respectively. Both nanosystems were physically stable for at least 120 days and showed to be non-irritating to reconstructed human epidermis. Chitosan coating promoted active penetration into undamaged skin areas, which were still covered by the stratum corneum. In conclusion, the present study demonstrated for the first time the biotechnological potential of the frequently discarded Cupuaçu seed as a valuable pharmaceutical ingredient to be used in regenerative skin products.

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Section: Skin Penetrationmentioning

confidence: 99%

Skin Regenerative Potential of Cupuaçu Seed Extract (Theobroma grandiflorum), a Native Fruit from the Amazon: Development of a Topical Formulation Based on Chitosan-Coated Nanocapsules

et al. 2022

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“… 43 In this sense, even the scalp condition prior to the formulation application, ie, whether the scalp is wet or dry, can affect formulations efficiency. 44 Besides, there are several undesirable formulations’ characteristics that limit patient compliance, from the unpleasant smell to the “hard” aspect they leave the hair. Patients who have dyed hair also face speeded discoloration issues.…”

Section: Challenges Of Current Topical Treatments For Alopeciamentioning

confidence: 99%

Topical Treatment for Scarring and Non-Scarring Alopecia: An Overview of the Current Evidence

Cardoso

Tolentino

Gratieri

et al. 2021

CCID

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Alopecia is a clinical condition related to hair loss that can significantly affect both male and female adults' quality of life. Despite the high market demand, only few drugs are currently approved for alopecia treatment. Topical formulations still bring drawbacks, such as scalp irritation with frequent use, and low drug absorption to the site of action, which limits the efficacy. The most recent research points out that different formulation technology could circumvent the aforementioned flaws. Such technology includes incorporation of drugs in rigid or deformable nanoparticles, strategies involving physical, energetical and mechanical techniques, such as iontophoresis, sonophoresis, microneedling, and the use of solid effervescent granules to be hydrated at the moment of application in the scalp. In this paper, the progress of current research on topical formulations dedicated to the treatment of alopecia is reviewed and discussed.

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“…Use of a high‐concentration (15%) topical minoxidil solution resulted in 60% of subjects achieving a clinically significant response based on target area hair counts . Scalp hydration was also reported to improve the drug permeation rate . A 5% minoxidil topical foam used once daily has been reported to be safe and effective in improving hair regrowth, scalp coverage and hair density in women with female pattern hair loss .…”

Section: Key Issues In Hair Loss: From Physiology To Treatmentmentioning

confidence: 99%

Dermatology today and tomorrow: from symptom control to targeted therapy

Blume-Peytavi

Bagot

Tennstedt

et al. 2018

Acad Dermatol Venereol

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For many decades and until recently, medical approach to dermatologic diseases has been based on the physician's ability to recognize and treat symptoms. Nowadays, advances in the understanding of the biology of diseases and in technologies for intervening against them have allowed physicians to diagnose and treat underlying disease processes rather than simply addressing the symptoms. This means that rather than addressing ‘the disease in humans’, physicians can now address the particular pathologic (biologic, molecular) disturbance as it presents in the individual patient, i.e., physicians now can practice something much closer to ‘personalized medicine’, leading to greater benefits for the patients and the health of society in general. The deeper understanding of ultraviolet radiation, the importance of photoprotection and increased knowledge about signalling pathways of melanoma and carcinoma have led to more complete care for the dermatologic patient. The current popularity for excessive exposure to the sun, without adequate application of the appropriate photoprotection remedies, is the origin of melanoma, but also for the weakening of the structure and functions of the skin. Indeed, fragility of the skin can affect humans around the world. In the senior population, this skin fragility is accompanied by pruritus, whereas atopic dermatitis is an inflammatory disease with highest prevalence in children and adolescents. Acne, the number one reason for dermatologic consultations worldwide, increases its prevalence in adolescents and in females. Senescent alopecia affects humans after menopause and andropause. The articles in this publication present an overview of the current advanced understanding of the diagnosis and therapeutic approaches in 6 fields of dermatology – dermatopaediatry and gerontodermatology, oncodermatology, hair loss, atopic dermatitis, photoprotection and acne – and thereby serve as a useful compendium of updated information and references for all healthcare professionals who see patients with presentations of the symptoms of these diseases.

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Minoxidil topical treatment may be more efficient if applied on damp scalp in comparison with dry scalp

Cited by 14 publications

References 8 publications

Skin Regenerative Potential of Cupuaçu Seed Extract (Theobroma grandiflorum), a Native Fruit from the Amazon: Development of a Topical Formulation Based on Chitosan-Coated Nanocapsules

Skin Regenerative Potential of Cupuaçu Seed Extract (Theobroma grandiflorum), a Native Fruit from the Amazon: Development of a Topical Formulation Based on Chitosan-Coated Nanocapsules

Topical Treatment for Scarring and Non-Scarring Alopecia: An Overview of the Current Evidence

Dermatology today and tomorrow: from symptom control to targeted therapy

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