Minority recruitment to the Selenium and Vitamin E Cancer Prevention Trial (SELECT)

Cook, Elise D.; Moody–Thomas, Sarah; Anderson, Karen; Campbell, Russell; Hamilton, Sandra J.; Harrington, Joseph M; Lippman, Scott M.; Minasian, Lori M.; Paskett, Electra D.; Craine, Stephen; Arnold, Kathryn B.; Probstfield, Jeffrey L.

doi:10.1191/1740774505cn111oa

Cited by 49 publications

(43 citation statements)

References 22 publications

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“…1,53 Even if enrollment of minorities is adequate in the treatment trial setting, enrollment of minority healthy volunteers for prevention trials has been decidedly more difficult, and has generated well-designed outreach programs for large individual trials. 62,63,64,65 Given the increasingly diverse nature of the US population, continued attention to this issue is required.…”

Section: Understanding Barriers To Clinical Trial Participationmentioning

confidence: 99%

“…The SELECT trial enrolled over 35,000 men in the United States, Canada, and Puerto Rico, and completed enrollment two years ahead of schedule. 62,63 On a smaller accrual scale, the contributions of the International Breast Cancer Study Group, in collaboration with the cooperative groups of the NCI, provided necessary accrual to a trial evaluating ovarian failure in premenopausal women with breast cancer. 103 …”

Section: Global and Local Strategies To Improve Clinical Trial Particmentioning

confidence: 99%

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The Role of Clinical Trial Participation in Cancer Research: Barriers, Evidence, and Strategies

Unger

Cook

Tai

et al. 2016

American Society of Clinical Oncology Educational Book

428

284

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OVERVIEW Fewer than 1 in 20 adult cancer patients enroll in cancer clinical trials. But although barriers to trial participation have been the subject of frequent study, the rate of trial participation has not changed substantially over time. Barriers to trial participation are structural, clinical, and attitudinal, and differ according to demographic and socioeconomic factors. In this paper, we characterize the nature of cancer clinical trial barriers, and we consider global and local strategies for reducing barriers. We also consider the specific case of adolescents with cancer, and show that the low rate of trial enrollment in this age group strongly correlates with limited improvements in cancer population outcomes compared to other age groups. Our analysis suggests that a clinical trial system that enrolls patients at higher rates produces treatment advances at a faster rate and corresponding improvements in cancer population outcomes. Viewed in this light, the issue of clinical trial enrollment is foundational, lying at the heart of the cancer clinical trial endeavor. Fewer barriers to trial participation would allow trials to be completed more quickly and would improve the generalizability of trial results. Moreover, increased accrual to trials is important to patients, since trials provide patients the opportunity to receive the newest treatments. In an era of increasing emphasis on a treatment decision-making process that incorporates the patient perspective, the opportunity for patients to choose trial participation for their care is vital.

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Section: Understanding Barriers To Clinical Trial Participationmentioning

confidence: 99%

Section: Global and Local Strategies To Improve Clinical Trial Particmentioning

confidence: 99%

The Role of Clinical Trial Participation in Cancer Research: Barriers, Evidence, and Strategies

Unger

Cook

Tai

et al. 2016

American Society of Clinical Oncology Educational Book

428

284

View full text Add to dashboard Cite

show abstract

“…Recruitment may be more successful when culturally tailored materials are used, when one-to-one contact is made, and when the message comes from a respected member of the community, a personal physician, or another known person (Klabunde & Kaluzny 1995;Gilliss et al 2001;Ford et al 2004;Sheppard et al 2005;Cook et al 2005;McCaskillStevens et al 2005). These strategies can enhance the trust in researchers that is often lacking in marginalized communities or among groups who have experienced discrimination or abuse (e.g.…”

Section: Introductionmentioning

confidence: 99%

Recruiting Low-Income Healthy Women to Research: An Exploratory Study

2007

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Objective-The study goals were (1) to assess the feasibility of using an existing telephone health information and referral service for low-income, ethnically diverse women to recruit women for research participation; (2) to assess the feasibility of recruiting low-income, African American and Latino men into health research through the women callers to the telephone service; and (3) to describe the challenges women face and the strategies they use when talking to men about the men's health and research participation.Design-We recruited women for individual semi-structured qualitative interviews via the Every Woman Counts (EWC) telephone information and referral service, a California Department of Health Services Cancer Detection Program. This paper describes our eligibility and recruitment assessment, and our qualitative data from 23 interviews with low-income African American and Latino women who called EWC.Results-We found that it was feasible to recruit women, but not to recruit men through women who call this telephone service. Almost 50% (113) of women demographically eligible for recruitment, completed our screening questionnaire, despite calling EWC for a different purpose. Some 48% (54) of those women were eligible for an interview. Of interview-eligible women, 58% (10) of African Americans and 35% (13) of Latinos completed an interview. Only 17% (4) of women referred a man for participation in an interview for our study. Several themes emerged from our analysis of interview data: (1) women's role in men's health can be significant but is often uneasy; (2) challenges when talking to men about their health include health access, gender dynamics, and men's fear of health care; (3) women's understanding of research may be limited; (4) women use a range of strategies to address and overcome men's resistance to taking care of their health and participating in research. Conclusions-The challenges women face when talking with men about their health affect their ability to effectively speak to men about research participation. However, EWC and similar telephone health services may be an effective means for recruiting low-income women to chemoprevention and other studies requiring healthy participants. HHS Public Access

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“…SELECT took special efforts to recruit a representative proportion of minority participants, particularly Blacks, through its selection of study sites, modified eligibility criteria and creation of sub-committees and grants designed to enhance both overall and minority recruitment and retention (18-20). Eligibility criteria were adjusted to permit registration of men with controlled co-morbid conditions, allowing for more eligible Black participants because of the generally higher rates of comorbidities among Blacks (21-23).…”

Section: Introductionmentioning

confidence: 99%

“…Specific SELECT recruitment and retention strategies are shown in Table 1; a full discussion of SELECT's minority recruitment strategies is presented elsewhere (18). SELECT recruitment was very successful, surpassing the study's accrual goal 28 months ahead of schedule.…”

Section: Introductionmentioning

confidence: 99%

Retention of Black and White Participants in the Selenium and Vitamin E Cancer Prevention Trial (SWOG-Coordinated Intergroup Study S0000)

Arnold

Hermos

Anderson

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Disproportionally low retention of minority populations can adversely affect the generalizability of clinical research trials. We determine the overall retention rates for White and Black participants from the Selenium and Vitamin E Cancer Prevention Trial (SELECT) and explore participant and site characteristics associated with retention failure (study disengagement)for these groups. Methods A secondary analysis of 28,118 White (age ≥55), and 4,322 Black (age ≥ 50) SELECT participants used multivariate Cox regression to estimate overall retention rates and to calculate hazard ratios (HR) and 95% confidence intervals (CI). Results Blacks had higher age-adjusted risk of disengagement than Whites (HR=1.92; 95% CI,1.77-2.08). Among Black participants, those age 50-54 were at three times the risk of disengagement than those age ≥65 (HR=3.61; 95%CI,2.41-5.41). Blacks age ≥65 had 1.6 times the risk of disengagement than Whites age ≥65 (HR=1.60; 95%CI,1.38-1.87). By six years post-randomization, 84% of Whites and 69% of Blacks remained engaged in the study. Current smoking status was an independent risk factor for study disengagement for both White and Black participants. For both groups, sites whose staffs missed SELECT training sessions or who received SELECT Retention and Adherence grants were associated with increased and decreased disengagement risks, respectively. Conclusions SELECT retention was disproportionately lower for Blacks than for Whites. Impact The observed difference in retention rates for Blacks and Whites and factors identified by race for study disengagement in SELECT may inform retention efforts for future long-term, cancer prevention trials.

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Minority recruitment to the Selenium and Vitamin E Cancer Prevention Trial (SELECT)

Cited by 49 publications

References 22 publications

The Role of Clinical Trial Participation in Cancer Research: Barriers, Evidence, and Strategies

The Role of Clinical Trial Participation in Cancer Research: Barriers, Evidence, and Strategies

Recruiting Low-Income Healthy Women to Research: An Exploratory Study

Retention of Black and White Participants in the Selenium and Vitamin E Cancer Prevention Trial (SWOG-Coordinated Intergroup Study S0000)

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