Minor salivary gland tumors. A histologic and immunohistochemical study

Regezi, Joseph A.; Lloyd, Ricardo V.; Zarbo, Richard J.; McClatchey, Kenneth D.

doi:10.1002/1097-0142(19850101)55:1<108::aid-cncr2820550118>3.0.co;2-2

Cited by 136 publications

(76 citation statements)

References 13 publications

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“…Based on the findings in this series and those reported earlier, this tumor is a luminal epithelial lineage. The tumor cells show a strong reaction with epithelial markers, including AE1/ AE3, CK7, CAM5.2, CK903, EMA, and CK19; reactions with CK8 and CK13 are also reported [14,15,21,29,40,79,98,99]. Further, the neoplastic cells are strongly and diffusely reactive with S100 protein [14,100], despite earlier reports of negative reactions [40,79].…”

Section: Immunohistochemical Studiessupporting

confidence: 63%

“…Several studies were excluded if no specific or separable information was given about CanAd or if the illustrations were not characteristic [23,51,55,[59][60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78]. Several of the cases seemed to have been included multiple times in different series reports [9,10,40,[79][80][81][82][83].…”

Section: Methodsmentioning

confidence: 99%

“…The tumor cells show a strong reaction with epithelial markers, including AE1/ AE3, CK7, CAM5.2, CK903, EMA, and CK19; reactions with CK8 and CK13 are also reported [14,15,21,29,40,79,98,99]. Further, the neoplastic cells are strongly and diffusely reactive with S100 protein [14,100], despite earlier reports of negative reactions [40,79]. The distinctive linear reaction of GFAP at the tumor to connective tissue interface previously reported [72], was reproduced in the current series.…”

Section: Immunohistochemical Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Canalicular Adenoma: A Clinicopathologic and Immunohistochemical Analysis of 67 Cases with a Review of the Literature

Thompson

Bauer

Chiosea

et al. 2014

Head and Neck Pathol

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There is a lack of a comprehensive immunohistochemical (IHC) analysis of canalicular adenoma (CanAd), especially when combined with a description of the unique histologic features. Given the usual small biopsies, IHC may be useful in distinguishing CanAd from other tumors in the differential diagnosis. Retrospective. The patients included 54 females and 13 males (4.2:1), aged 43-90 years, with a mean age at presentation of 69.9 years. Clinical presentation was generally a mass (n = 61) slowly increasing in size (mean 38.5 months), affecting the upper lip (n = 46), buccal mucosa (n = 17) or palate (n = 4), involving the right (n = 29), left (n = 24) or midline (n = 9), without any major salivary gland tumors. The tumors ranged in size from 0.2 to 3 cm (mean 1.2 cm). Most tumors were multilobular or bosselated (76 %), often surrounded by a capsule. Histologically, the tumors were characterized by cystic spaces, tumor cords with beading, tubule formation, and by the presence of luminal squamous balls (n = 41). The cells were cuboidal to columnar with stippled chromatin. Mitoses were inconspicuous. A myxoid stroma (n = 64), sclerosis (n = 42), luminal hemorrhage (n = 51), and luminal microliths (calcifications) (n = 33) were characteristic. Nine (13.4 %) were multifocal. CanAd showed the following characteristic immunohistochemistry findings: CK-pan and S100 protein (strong, diffuse reaction); peripheral or luminal GFAP reaction; CK5/6 and p16 luminal squamous ball reaction; SOX10 nuclear reaction; cytoplasmic p63 reaction. CanAd are unique minor salivary gland tumors showing a distinct architecture and phenotype. They predilect to older women, with the majority multilobulated and affecting the upper lip, multifocal in 13 %; no major salivary gland tumors were identified. S100 protein, CK-pan, GFAP and SOX10 are positive, with luminal squamous balls highlighted by CK5/6 or p16.

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Section: Immunohistochemical Studiessupporting

confidence: 63%

Section: Methodsmentioning

confidence: 99%

Section: Immunohistochemical Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Canalicular Adenoma: A Clinicopathologic and Immunohistochemical Analysis of 67 Cases with a Review of the Literature

Thompson

Bauer

Chiosea

et al. 2014

Head and Neck Pathol

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“…Several studies (Chaudhry et al 1961;Eneroth 1971;Eneroth and Hjertman 1972;Isacsson and Shear 1983;Eveson and Cawson 1985a, b ;Regezi et al 1985) have documented the distribution of series of minor salivary gland tumors seen in some countries. Reports from various parts of the world indicate that there are differences in the frequency of particular histologic types and in the frequency with which minor salivary glands are involved.…”

Section: )mentioning

confidence: 99%

Intraoral minor salivary gland tumors: A demographic and histologic study of 200 cases.

Takahashi

Fujita

Tsuda

et al. 1990

Tohoku J. Exp. Med.

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In a demographic and histologic study of 200 intraoral minor salivary gland tumors seen in Japan (Nagasaki and Miyagi prefectures), 127 cases (63.5%) were classified as benign, comprising 124 pleomorphic adenomas and 3 monomorphic adenomas. The other 73 cases (36.5%) were malignant tumors, represented by 33 adenoid cystic carcinomas, 16 mucoepidermoid carcinomas, 10 carcinoma in pleomorphic adenomas, 6 acinic cell carcinomas, 5 adenocarcinomas, one polymorphous low-grade adenocarcinoma, one undifferentiated carcinoma and one clear cell carcinoma. There was an overall female preponderance (1.78/1). The mean age for females was 47.2 years and for males was 50.6 years. The mean age for patients with malignant tumors was 10 years greater than for patients with benign tumors and was statistically significant. The palate was the most common site for intraoral minor salivary gland tumors followed by the lip and buccal mucosa. These three sites accounted for 83° of all cases. Tumors arising in these three sites were predominantly benign. In contrast, those located in the gingiva, floor of the mouth and tongue were predominantly malignant. The results of this study were compared with other recent studies.-minor salivary gland ; tumors ; histology ; age and sex ; Japanese Neoplasms of minor salivary gland origin occur much less commonly than those arising from major salivary glands (Gorlin and Chaudhry 1957;Richardson et al. 1975;Main et al. 1976;Shrikhande and Talvalker 1978;DelBalso 1979;Perzin and LiVolsi 1979;Brocheriou et al. 1980;Eveson and Cawson 1985b). In spite of their relative infrequency in terms of the total number of cases accessioned in most oral or hospital surgical pathology services (Regezi et al.

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“…However , myoepithe- lial cells surrounding acini and intercalated ducts were specifically positive for S-100 protein [19][20][21]. On the other hand, NAKAZATO et al [12] and ERLANDSON et al [22] demonstrated that acini cells were S-100 protein-positive in some of the cases they examined, and other reports also described S-100 protein immunoreactivity in intercalated ducts [11,12,14,18,19]. The variation in findings among these studies may be ascribed to the differing sensitivities of the immunoperoxidase methodologies employed by various laboratories, different primary antibody sources, poor specimen fixation and differences in sample size [18,19].…”

Section: Solid Epithelial Areasmentioning

confidence: 99%

Immunohistochemical Study of the Distribution of S-100 Protein in Pleomorphic Adenomas of Minor Salivary Glands.

Star

Ng²

1992

The Journal of Nihon University School of Dentistry

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Twelve pleomorphic adenomas of minor salivary gland origin were examined for the distribution of S-100 protein, detected using the peroxidase-antiperoxidase (PAP) method. Strong S-100 protein immunoreactivity was noted in areas containing plasmacytoid cells, stellate and spindle cells against a myxochondroid or hyalinous stroma, and solid epithelial areas. Tubular and duct-like structures showed variable stainability. Stromal tissue and normal salivary glands were generally negative for S-100 protein. These findings were compared with those reported elsewhere.

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Minor salivary gland tumors. A histologic and immunohistochemical study

Cited by 136 publications

References 13 publications

Canalicular Adenoma: A Clinicopathologic and Immunohistochemical Analysis of 67 Cases with a Review of the Literature

Canalicular Adenoma: A Clinicopathologic and Immunohistochemical Analysis of 67 Cases with a Review of the Literature

Intraoral minor salivary gland tumors: A demographic and histologic study of 200 cases.

Immunohistochemical Study of the Distribution of S-100 Protein in Pleomorphic Adenomas of Minor Salivary Glands.

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