Minor Salivary Gland Transplantation

Geerling, Gerd; Raus, Peter; Murube, Juan

doi:10.1159/000131093

Cited by 49 publications

(46 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Dudak mukozası greftleri okü-ler skatrisyel konjonktivit, kseroftalmi ve anoftalmik soket rekonstrüksiyonunda kullanılagelmek-tedir. [23][24][25][26] Dudakta hipoestezi, pitozis, entropiyon, greft nekrozu, herpetik keratit ve epifora dudak mukozası greftinin olası komplikasyonlarını oluş-turmaktadır. Olgumuzda tarsal bir defektin olmayışı, cerrahisinin kolay uygulanabilir olması, ret olasılığının düşük olması nedeni ile dudak mukozası grefti tercih edildi.…”

Section: Discussionunclassified

Oral Mucosal Grafts in Severe Pterygium: Case Report

Koçak¹,

İlhan²,

Bilgin³

et al. 2017

Turkiye Klinikleri J Ophthalmol

View full text Add to dashboard Cite

iterjium, konjonktivadan başlayıp korneaya doğru ilerleyen, kanatsı özellikte fibrovasküler doku proliferasyonudur. Piterjium tedavisinde birçok tedavi yöntemi tanımlanmış olsa da piterjium cerrahi bir problem olmaya devam etmektedir. Konjonktival fornikste kısalma, semblefaron gelişimi, korneal melting varlığında ya da kornea santralini de içine alan ileri piterjiumlarda bu sorun daha da büyük olmaktadır. Nüks varlığında; komplikasyon görülme olasılığı artmakta ve tedavi başarı şansı düşmekte-dir.1 Tekrarlayan cerrahiler, limbal bölgedeki bariyer fonksiyonuna zarar vererek, fibroz doku proliferasyonunda artışı beraberinde getirmektedir. Bu komplike hâle gelmiş durum; hastada kızarıklık, batma ve sulanma; yanı Turkiye Klinikleri J Ophthalmol 2017;26(4):297-303 297 İleri Piterjiumda Oral Mukozal Greft Uygulaması Ö ÖZ ZE ET T İleri ve nüks pterjiumlar; klinikte görme keskinliğinde azalma, göz hareketlerinde kısıtlı-lıkla karşımıza gelmektedir. Tedavisinde çoğunlukla klasik cerrahi teknikler yetersiz kalmaktadır. Konjonktival otogreft tekniği kısa cerrahi süresi ve düşük nüks oranları nedeni ile tercih sebebidir. Amniyotik membran greftleri; antiinflamatuar, antianjiyogenik ve antiproteolitik aktivitesi sayesinde skar oluşumunun önüne geçebilmektedir. Konjonktival otogreft ve amniyotik membran transplantasyonunun kombine edildiği çalışmalarda iyi sonuçlar alınmaktadır. Ancak yeterli, sağ-lıklı konjonktivanın olmadığı hastalarda ek cerrahi yöntemler gerekmektedir. Bu durumda mukoza grefti kullanımı düşünülmelidir. Mukoza greftleri oral (bukkal, dudak, sert damak) ya da nazal böl-geden alınabilir. Bu çalışmada, konjonktiva ve dudak mukozası otogrefti ile amniyotik membran transplantasyonunu bir arada uyguladığımız, ileri piterjiumlu bir olgu sunulmuştur.A An na ah ht ta ar r K Ke el li im me el le er r: : Piterjium; muköz membran; transplantasyon, otolog; amniyon A AB BS ST TR RA AC CT T Severe and recurrent pterygium; come out with decreased visual acuity, limitation of eye movements in clinic. Classical surgical techniques are mostly insufficient for treatment. The technique of conjunctival autograft is preferred due to short surgery duration and low recurrence rate. Amniotic membrane grafts; may prevent the scar formation with their anti-inflammatory, anti-angiogenic and anti-proteolytic activity. In studies of amniotic membrane transplantation combined with conjunctival autograft are taken good results. If there is not enough healthy conjunctiva; additional surgical procedures are required. In this situation, use of mucosal graft should be considered. Mucosal grafts can be obtained from oral (buccal, lips, hard palate) or nasal region. In this study; we presented a combined lip mucosa and conjunctival autograft with amniotic membrane transplantation procedure, in a case of severe pterygium.

show abstract

Section: Discussionunclassified

Oral Mucosal Grafts in Severe Pterygium: Case Report

Koçak¹,

İlhan²,

Bilgin³

et al. 2017

Turkiye Klinikleri J Ophthalmol

View full text Add to dashboard Cite

show abstract

“…52 Although the ocular tear film is complex and unique, the mucinous composition of major and minor salivary glands approaches the relative osmolality and protein content of tears. 53,55,56 The procedure is to transfer the submandibular gland to the temporal fossa posterior to the frontal branch of the facial nerve. The secretory duct is passed subcutaneously to its distal end at the temporal edge of the upper lid tarsus.…”

Section: Autologous Gland Transplantationmentioning

confidence: 99%

“…53 In the limited long-term studies that have been performed, approximately half of patients reported subjective improvement when judged against the complexity and burden of the surgical procedures and follow-up. 57 Benefits include reduced reliance on artificial tear substitutes, improved corneal fluorescein staining, and improved visual acuity.…”

Section: Autologous Gland Transplantationmentioning

confidence: 99%

“…Along with the risk of host site numbness, recipient site necrosis, and transplantation failure, additional reports of herpetic keratitis, ptosis, and entropion limit widespread use of this technique. 53,54 The procedure also requires a multidisciplinary approach with otorhinolaryngology, oral maxillofacial, and ophthalmologic consultation, which can be difficult to coordinate.…”

Section: Autologous Gland Transplantationmentioning

confidence: 99%

See 1 more Smart Citation

Ophthalmic Procedures for Treatment of Advanced Ocular Surface Diseases

Bartlett¹,

Bartlett²

2015

Optometry and Vision Science

View full text Add to dashboard Cite

Dry eye disease and other ocular surface diseases are complex multifactorial disorders often characterized by ocular surface inflammatory changes, instability of the tear film, and functional vision impairment. Recent research has led to new concepts regarding diagnosis and management, and therapeutic interventions now include ocular lubricants, secretagogues, topical and systemic anti-inflammatory and immunosuppressive agents, tear preservation, and, for advanced cases, a variety of surgical approaches. This review considers contemporary procedures for treatment of advanced ocular surface diseases, including thermal and electrocautery of the lacrimal puncta, lid surgeries such as tarsorrhaphy, and multiple procedures to protect the exposed or compromised ocular surface.

show abstract

“…Keratoconjunctivitis sicca, or dry eye syndrome is a very complex multifactorial disease [7], which, as the name indicates, in virtually all cases results in reduced tear volume production, which is reported to be associated with a decreased general lacrimal protein secretion. Very severe cases are uniquely treated by autotransplantation of a minor salivary gland into the eye, a technique originally introduced by Prof. J. Murube and perfectionized over the past ten years [5]. The rationale behind a proteomics analysis of clinically sampled tears is that comparative protein composition analysis of tears from diseased versus treated and/or healthy eyes, may yield medically relevant information regarding both the effectiveness of the treatment and the possible disease etiology.…”

Section: Introductionmentioning

confidence: 99%

Bottom–up protein identifications from microliter quantities of individual human tear samples. Important steps towards clinical relevance.

Raus

Raghuraman

Pinkse

et al. 2015

EuPA Open Proteomics

Self Cite

View full text Add to dashboard Cite

A B S T R A C TA relatively simple combination of Schirmer strip sampling with straightforward sensitive nanoLC quadrupole-Orbitrap tandem mass spectrometry after a minimum of sample processing steps allows for replicate proteomic analysis of single human tears, i.e., without the requirement for sample pooling. This opens the way to clinical applications of the analytical workflow, e.g., to monitor disease progression or treatment efficacy within individual patients. Proof of concept is provided by triplicate analyses of a singular sampling of tears of a dry eye patient, before and one and two months after minor salivary gland transplantation. To facilitate comparison with the outcome of previously reported analytical protocols, we also include the data from a typical healthy young adult tear sample as obtained by our streamlined method.With 375 confidently identified proteins in the healthy adult tear, the obtained results are comprehensive and in large agreement with previously published observations on pooled samples of multiple patients. We conclude that, to a limited extent, bottom-up tear protein identifications from individual patients may have clinical relevance.

show abstract

Minor Salivary Gland Transplantation

Cited by 49 publications

References 32 publications

Oral Mucosal Grafts in Severe Pterygium: Case Report

Oral Mucosal Grafts in Severe Pterygium: Case Report

Ophthalmic Procedures for Treatment of Advanced Ocular Surface Diseases

Bottom–up protein identifications from microliter quantities of individual human tear samples. Important steps towards clinical relevance.

Contact Info

Product

Resources

About