Minor Salivary Gland Carcinoma of the Oropharynx: A Population‐Based Analysis of 1426 Patients

Abstract

Objective We sought to describe the patient, tumor, and survival characteristics of minor salivary gland carcinoma (MSGC) of the oropharynx using a large, population-based database. Study Design Cross-sectional analysis of the National Cancer Institute's SEER database (Surveillance, Epidemiology. and End Results). Subjects and Methods We reviewed the SEER database for all cases of MSGC of the oropharynx from 1988 to 2013. Relevant demographic, clinicopathologic, and survival variables were extracted and analyzed. Cox multivariate regression was performed to identify prognostic factors. Results We identified 1426 cases of MSGC of the oropharynx (mean age, 58 years; 51% female). The soft palate (39.2%) and base of tongue (38.6%) were the most commonly involved sites. The most common histologic subtypes were mucoepidermoid carcinoma (32.1%), adenocarcinoma (25.9%), and adenoid cystic carcinoma (23.3%). Five- and 10-year rates of disease-specific survival were 75.1% and 61.6%, respectively. Independent prognostic factors included tumor grade, T stage, N stage, and age >70 years. Conclusions This study represents the largest multivariate survival analysis of MSGC of the oropharynx to date. Independent prognosticators include tumor grade, T stage, N stage, and age.

Salivary Gland Cancers of the Nasopharynx: A Population‐Based Analysis of 383 Cases

“…Five- and 10-year DSS rates were measured at 58.4% and 40.8%, as opposed to 75.1% and 61.6% for the oropharynx, respectively. 17 SGNPCs do demonstrate similar but worse long-term prognoses as compared with laryngeal minor salivary gland tumors, which have 5- and 10-year DSS rates of 52.6% and 45.3%. 18 However, it is important to note that adenoid cystic carcinoma, the most common SGNPC histology identified in the present study, was only the third-most common in the oropharynx and larynx.…”

Prognostic value of primary tumor surgery in minor salivary-gland carcinoma patients with distant metastases at diagnosis: first evidence from a SEER-based study

“…Patients were included in our study if the following criteria were met: 1) histologic subtypes identified using the third-edition ICD for Oncology (ICD-O3) codes for adenocarcinoma (8140, 8147, 8290, 8310, 8410, 8440, 8480, 8525, and 8550), mucoepidermoid carcinoma (8430), adenoid cystic carcinoma (8200), mixed subtype (8980 and 8981), and other rare carcinomas (8012, 8041, 8082, 8562, and 8982), which was the same as the methodology of previous studies using the SEER database; 3 , 9 , 21 2) histologic subtypes confirmed by aspiration cytology, biopsy, or postoperative pathology report; 3) primary site included oral cavity (ICD-O3 topography codes C00.0–C00.9, C02.0–C02.3, C02.8–C02.9, C03.0–C03.9, C04.0–C04.9, C05.0, and C06.0–C06.1), oropharynx (C01.9, C02.4, C05.1–C05.2, and C09.0–C10.9), larynx (C32.0–C32.9), hypopharynx (C12.9–C13.2), nasal cavity (C30.0), and paranasal sinus (C31.0–C31.9). MiSGCs originating from nasopharynx (C11.0–C11.9) were excluded, as none of these patients had undergone PTS, and more importantly almost all these tumors were recorded as lymphoepithelial carcinoma (8082), which was difficult to distinguish from the more common primary nasopharyngeal SCC; 2 4) patients diagnosed between January 1, 2004 and June 30, 2014, because some important factors are merely available for patients diagnosed after 2004, such as the American Joint Committee on Cancer (AJCC) TNM staging.…”

Development and Validation of Nomograms to Predict Prognosis of Oral and Oropharyngeal Mucoepidermoid Carcinoma: A SEER-Based Study

“…First, our nomograms focus only on one histological subtype of minor salivary gland carcinoma arising from the oral cavity or oropharynx, which enables greater accuracy and reliability of our nomograms. Specifically, our prognostic nomograms yielded a very high C-index (0.899 for OS prediction and 0.893 for DSS prediction) and AUC, indicating excellent prognostic prediction ability compared to previous models 3, 13,16 . Last but not least, one independent validation set and three validation methods were utilized in the current study to guarantee stability and reliability of our prognostic nomograms.…”

“…However, the number of cases in their study was too small to draw any conclusions. In 2017, Goel et al 13 conducted a population-based analysis of 1426 patients with minor salivary gland carcinoma of the oropharynx and demonstrated that tumor grade, T stage, N stage and age were independent prognosticators. They reported 5-year and 10-year disease-specific survival rates of 75.1% and 61.6%, respectively.…”