Minor physical anomalies in women with recurrent unipolar depression

Čulav-Sumić, Jadranka; Jukić, Vlado

doi:10.1016/j.psychres.2008.10.014

Cited by 7 publications

(6 citation statements)

References 34 publications

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“…12,[32][33][34] However, after excluding patients with these characteristics, we still identified an association between CHD and psychiatric disorders. We found an increased risk of psychiatric disorders among CHD patients in the younger age group (0 -14 years) but not in the older age group (15-30 years) compared with diabetes and asthma patients.…”

Section: Discussionmentioning

confidence: 78%

Congenital Heart Defects and Developmental and Other Psychiatric Disorders

et al. 2011

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Background— We examined the risk of psychiatric in-patient admissions and out-patient visits among Danish patients with congenital heart defects (CHD). Methods and Results— Using the Danish National Registry of Patients, we identified CHD patients born January 1, 1977, to January 1, 2002. For each patient, we randomly selected 10 population-comparison cohort members from the Danish Civil Registration System, matched by sex and birth year. We computed cumulative risk and hazard ratios (HRs) of time to first psychiatric in-patient admission or out-patient visit identified in the Danish Psychiatric Central Registry and adjusted for parents' educational level and parents' psychiatric morbidity. We identified 6927 CHD patients. At 15 years of age, the cumulative risk of psychiatric admissions or out-patient visits was 5.9% (95% confidence interval [CI], 5.2%–6.6%) among CHD patients. The HRs for CHD patients and comparison cohort members aged 0 to 14 years were 1.8 (95% CI: 1.5–2.1) for males and 2.5 (95% CI: 2.0–3.1) for females. For patients aged 15 to 30 years, the HRs were 1.6 (95% CI: 1.2–2.0) for males and 1.0 (95% CI: 0.8–1.3) for females. Congenital heart defect patients, both with and without invasive therapeutic interventions or extracardiac defects or syndromes, had a higher risk of psychiatric in-patient admissions or out-patient visits than comparison cohort members. After restriction of the comparison cohort to patients with diabetes mellitus or asthma (n=2554), the HR was 1.41 (95% CI: 1.07–1.85) for patients aged 0 to 14 years and 0.70 (95% CI: 0.52–0.94) for patients aged 15 to 30 years. Conclusion— Congenital heart disease patients with or without invasive therapeutic interventions are at increased risk of developmental and other psychiatric disorders, which seem to develop earlier than in patients with diabetes mellitus or asthma.

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Section: Discussionmentioning

confidence: 78%

Congenital Heart Defects and Developmental and Other Psychiatric Disorders

et al. 2011

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“…Other premorbid factors linked with PD when compared with NPD were rural domicile (Ihezue, 1985), acute medical problems (Draper & Anstey, 1996), and poorer social competence score (Sands & Harrow, 1995). When compared with HC, PD patients differed in the number of physical anomalies (Čulav-Sumić & Jukić, 2010) and also a loss of mother because of an unnatural cause after age 15 years associated with PD (Østergaard et al 2013). Ethnicity was studied in eight articles.…”

Section: Resultsmentioning

confidence: 99%

Epidemiology of psychotic depression – systematic review and meta-analysis

et al. 2017

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Large amount of data have been published on non-psychotic depression (NPD), schizophrenia (SZ), and bipolar disorder, while psychotic depression (PD) as an own entity has received much smaller attention. We performed a systematic review and meta-analyses on epidemiology, especially incidence and prevalence, risk factors, and outcomes of PD. A systematic search to identify potentially relevant studies was conducted using four electronic databases and a manual search. The search identified 1764 unique potentially relevant articles, the final study included 99 articles. We found that the lifetime prevalence of PD varies between 0.35% and 1%, with higher rates in older age. Onset age of PD was earlier than that of NPD in younger samples, but later in older samples. There were no differences in gender distribution in PD v. NPD, but higher proportion of females was found in PD than in SZ or in psychotic bipolar disorder (PBD). Risk factors have rarely been studied, the main finding being that family history of psychosis and bipolar disorder increases the risk of PD. Outcomes of PD were mostly worse when compared with NPD, but better compared with SZ and schizoaffective disorder. The outcome compared with PBD was relatively similar, and somewhat varied depending on the measure of the outcome. Based on this review, the amount of research on PD is far from that of NPD, SZ, and bipolar disorder. Based on our findings, PD seems distinguishable from related disorders and needs more scientific attention.

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“…In adults, MPA were observed in bipolar patients, (both bipolar I and bipolar II) (Berecz et al., 2017 ; Lloyd et al., 2008 ), where rates of MPA in such patients were found to be intermediate between schizophrenia subjects and controls (Akabaliev et al., 2014 ). MPAs were also observed in female patients with recurrent depression; similar rates in those psychotic and non‐psychotic (Culav‐Sumic et al., 2010 ). Moreover, despite there being no difference in MPA scores between alcohol dependent patients and controls, the distribution of scores was bimodal; suggesting group heterogeneity (Gualtieri et al., 1982 ).…”

Section: Introductionmentioning

confidence: 79%

“…A neurodevelopmental component had been suggested by Connan et al (2003) and is now being developed. A number of prenatal risk factors have been found: Abnormal testosterone balance, maternal infections like chickenpox or rubella, and low maternal vitamin D levels.…”

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confidence: 98%

Ectodermal disturbance in development shared by anorexia and schizophrenia may reflect neurodevelopmental abnormalities

Remberk

Niwiński²,

Brzóska-Konkol

et al. 2021

Brain and Behavior

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Minor physical abnormalities (MPA) are subtle dysmorphic features of bodily structures that have little or no impact on function. Most MPA develop during the first gestational trimester and are considered as important indicators of neuroectodermal deficiencies emerging during early brain development. A higher frequency of MPA was confirmed in schizophrenia patients and their relatives, when compared to controls.These findings are consistent with the neurodevelopmental model of schizophrenia.A neurodevelopmental component amongst other risk factors has also been recently proposed for anorexia nervosa (AN). The current study aimed to assess MPA frequency in adolescent inpatients with either schizophrenia spectrum disorders (SSD) or AN as compared to healthy controls (HC). The Waldrop Scale was used for assessing MPA.The mean MPA total score and mean head subscore was significantly higher in both test groups than in HC. There were no statistically significant differences between SSD and AN groups. The MPA profile (not frequency) was similar in all three groups. This finding is consistent both with widely acknowledged neurodevelopmental schizophrenia hypothesis as well as with more recent neurodevelopmental model of AN. Nevertheless, the findings should not be overgeneralized and further studies are warranted.

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Minor physical anomalies in women with recurrent unipolar depression

Cited by 7 publications

References 34 publications

Congenital Heart Defects and Developmental and Other Psychiatric Disorders

Congenital Heart Defects and Developmental and Other Psychiatric Disorders

Epidemiology of psychotic depression – systematic review and meta-analysis

Ectodermal disturbance in development shared by anorexia and schizophrenia may reflect neurodevelopmental abnormalities

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