Minor physical anomalies are more common in schizophrenia patients with the history of homicide

Tényi, Tamás; Halmai, Tamás; Antal, Ákos; Benke, Bálint; Jeges, Sára; Tényi, Dalma; Tóth, Arnold; Csábí, Györgyi

doi:10.1016/j.psychres.2014.11.012

Cited by 15 publications

(11 citation statements)

References 34 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More recently, MPAs have been found to be higher in schizophrenics who murder compared to both schizophrenics who do not murder as well as to normal controls (Tenyi et al, 2015). Within offenders, MPAs have been associated with more signs of pedophilic tendencies (Dyshniku, Murray, Fazio, Lykins, & Cantor, 2015).…”

Section: Minor Physical Anomaliesmentioning

confidence: 99%

A neurodevelopmental perspective on male violence

Raine

2018

Infant Mental Health Journal

View full text Add to dashboard Cite

Research is increasingly documenting a neurobiological basis to violence. This review takes a neurodevelopmental perspective on the very small group of males who grow up to become persistent violent offenders. After outlining six criteria for what constitutes a neurodevelopmental disorder, the extent to which chronic violence meets these definitional criteria is examined, covering the fields of genetics, structural and functional brain imaging, and neuropsychology. Early health risk factors for violence are then outlined, including birth complications, minor physical anomalies, prenatal smoking and alcohol exposure, poor nutrition, lead exposure, and traumatic brain injury. Persistent adult violence is argued to originate in aberrant temperamental behavior in early childhood, to have a stable developmental trajectory, and to be associated with impaired education, social, and occupational functioning. Taken together, it is argued that chronic adult violence meets criterion for being conceptualized as having neurodevelopmental origins and that an important, but not sole, source of neural maldevelopment lies in prenatal and early postnatal risk factors. This review concludes with a recognition of the sociopolitical context within which a neurodevelopmental perspective on chronic violence sits, together with directions for future research, including whether a neurodevelopmental hypothesis is best applied to reactive as opposed to proactive aggression.

show abstract

Section: Minor Physical Anomaliesmentioning

confidence: 99%

A neurodevelopmental perspective on male violence

Raine

2018

Infant Mental Health Journal

View full text Add to dashboard Cite

show abstract

“…We see as an important result, that relatives of bipolar I patients showed a higher frequency of MPAs in the eye, head and the mouth regions and one phenogenetic variant (high arched palate) was more prevalent in this group of individuals. Previous findings suggested, that anomalies of the head and the mouth may have more relevance to the hypothetical neurodevelopmental failure in patients with several neuropsychiatric disorders ( 2 , 8 , 12 , 15 , 24 – 26 ). In our previous study on the higher prevalence of minor physical anomalies among healthy schizophrenia relatives ( 9 ), in harmony with the results of Tikka et al ( 26 ), we reported that MPAs in the craniofacial region were significantly higher in the first-degree relative group than the healthy control group.…”

Section: Discussionmentioning

confidence: 97%

Increased Prevalence of Minor Physical Anomalies Among the Healthy First-Degree Relatives of Bipolar I Patients – Results With the Méhes Scale

et al. 2021

Self Cite

View full text Add to dashboard Cite

Minor physical anomalies are somatic markers of aberrant neurodevelopment, so the higher prevalence of these signs among the relatives of bipolar I patients can confirm minor physical anomalies as endophenotypes. The aim of the study was to evaluate the prevalence of minor physical anomalies in first-degree healthy relatives of patients with bipolar I disorder compared to normal control subjects. Using a list of 57 minor physical anomalies (the Méhes Scale), 20 first-degree unaffected relatives of patients with the diagnosis of bipolar I disorder and as a comparison 20 matched normal control subjects were examined. Minor physical anomalies were more common in the ear, head, mouth and trunk regions among the relatives of bipolar I patients compared to normal controls. By the differentiation of minor malformations and phenogenetic variants, we have found that both minor malformations and phenogenetic variants were more common among the relatives of bipolar I patients compared to the control group, while individual analyses showed, that one minor malformation (sole crease) and one phenogenetic variant (high arched palate) were more prevalent in the relative group. This is the first report in literature on the increased prevalence of minor physical anomalies among the first-degree unaffected relatives of bipolar I patients. The study support the concept, that minor physical anomalies can be endophenotypic markers of bipolar I affective disorder.

show abstract

“…Based on former data, our first hypothesis was that MPAs may be more common in BPD than in normal subjects. As previous findings suggested, anomalies of the head and the mouth may have more relevance to the hypothetical neurodevelopmental failure (4,7,9,(11)(12)(13), and it is theorized that MPAs at different localizations may represent different origins, such as familial vs. non-familial, so our second hypothesis was that a higher rate of MPAs may also be found predominantly in the head and facial regions in BPD compared to normal subjects.…”

Section: Introductionmentioning

confidence: 90%

“…MPAs are non-significant failures of morphogenesis, which persist into adult life and are easy to examine visually. They develop during the first and early second trimesters of gestation (6)(7)(8)(9)(10). As both the central nervous system and the skin are developed from the ectodermal tissue, MPAs may be external markers of abnormal brain development and their presence is a sensitive physical indicator of embryonic development.…”

Section: Introductionmentioning

confidence: 99%

Minor Physical Anomalies in Bipolar Disorder—A Meta-Analysis

et al. 2021

Self Cite

View full text Add to dashboard Cite

Introduction: Minor physical anomalies (MPAs) may reflect basic neurobiological features underlying bipolar disorders (BPD), as they are sensitive physical indicators of morphogenetic failure of the brain. Despite several researches about the presence of MPAs in BPD, the results are still controversial.Objectives: The aim of the present meta-analysis was to assess the standardized weighted mean effect sizes of MPAs in BPD and to examine if MPAs may be found predominantly in the head and/or facial regions in BPD patients compared to controls (HC).Methods: Four studies, involving 155 patients with BPD, and 187 HC, were involved in the analysis after searching the literature. For the investigation of MPAs in the peripheral (MPA-P) and in the head and facial regions (MPA-CF), two studies involving 121 BPD patients, and 133 HC passed the inclusion criteria.Results: The number of the MPAs in the BPD group was significantly higher compared to HC. Another important finding of the present study is that BPD patients' MPA-P scores do not significantly differ from those of the HC. In contrast, BPD patients' MPA-CF scores were found to be significantly higher compared to HC subjects. It is important to note that there was a low number of eligible publications included, which caused higher heterogeneity.Conclusions: Low quality of evidence suggests that MPAs are more common in patients with BPD than in HC and the higher rate of MPAs is found predominantly in the head and facial regions.

show abstract

Minor physical anomalies are more common in schizophrenia patients with the history of homicide

Cited by 15 publications

References 34 publications

A neurodevelopmental perspective on male violence

A neurodevelopmental perspective on male violence

Increased Prevalence of Minor Physical Anomalies Among the Healthy First-Degree Relatives of Bipolar I Patients – Results With the Méhes Scale

Minor Physical Anomalies in Bipolar Disorder—A Meta-Analysis

Contact Info

Product

Resources

About