Minocycline reduces ethanol drinking

Agrawal, Rajiv G.; Hewetson, Aveline; George, Christina; Syapin, Peter J.; Bergeson, Susan E.

doi:10.1016/j.bbi.2011.03.002

Cited by 121 publications

(101 citation statements)

References 20 publications

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“…Similarly, Hutchinson et al [21] demonstrated that, morphineinduced CPP is inhibited by minocycline in a dose of 25 mg/kg. In a recent study, Agrawal et al reported that minocycline in a dose of 50 mg/kg demonstrated significant reduction in alcohol intake in a free choice voluntary drinking model in both male and female C57Bl/6J mice [22].…”

Section: Discussionmentioning

confidence: 98%

Evaluation of effect of minocycline on rewarding potential and alcohol relapse in place preference model in mice

Gajbhiye

Tripathi

Salve

et al. 2017

Neuroscience Letters

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Section: Discussionmentioning

confidence: 98%

Evaluation of effect of minocycline on rewarding potential and alcohol relapse in place preference model in mice

Gajbhiye

Tripathi

Salve

et al. 2017

Neuroscience Letters

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“…Ibudilast is a phosphodiesterase inhibitor that suppresses pro-neuroinflammatory glial responses [16, 249]. In preclinical studies, minocycline and ibudilast have been shown to attenuate alcohol self-administration [250, 251], morphine-induced dopamine release in the nucleus accumbens [252], and morphine-conditioned place preference [253]. Recent studies have begun to investigate these medications in humans.…”

Section: Discussion and Future Directionsmentioning

confidence: 99%

Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review

et al. 2019

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There is tremendous interest in the role of the neuroimmune system and inflammatory processes in substance use disorders (SUDs). Imaging biomarkers of the neuroimmune system in vivo provide a vital translational bridge between preclinical and clinical research. Herein, we examine two imaging techniques that measure putative indices of the neuroimmune system and review their application among SUDs. Positron emission tomography (PET) imaging of 18 kDa translocator protein availability is a marker associated with microglia. Proton magnetic resonance spectroscopy quantification of myo-inositol levels is a putative glial marker found in astrocytes. Neuroinflammatory responses are initiated and maintained by microglia and astrocytes, and thus represent important imaging markers. The goal of this review is to summarize neuroimaging findings from the substance use literature that report data using these markers and discuss possible mechanisms of action. The extant literature indicates abused substances exert diverse and complex neuroimmune effects. Moreover, drug effects may change across addiction stages, i.e. the neuroimmune effects of acute drug administration may differ from chronic use. This burgeoning field has considerable potential to improve our understanding and treatment of SUDs. Future research is needed to determine how targeting the neuroimmune system may improve treatment outcomes.

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“…That excessive alcohol consumption produces neuroinflammation has been inferred from observations of increased expression of pro-inflammatory genes and cytokines following alcohol exposure (Crews et al, 2006c; He and Crews, 2008; Knapp and Crews, 1999; Qin et al, 2008), while other groups have shown that peripheral inflammation promotes increased ethanol consumption (Agrawal et al, 2011; Blednov et al, 2011). Furthermore, in animal models of chronic alcohol intake, innate immune signaling cascades are induced by ethanol activation of the pro-inflammatory transcription factor, nuclear factor-kappa-B (Crews et al, 2006a; Crews et al, 2011; Valles et al, 2004).…”

Section: Potential Mechanisms Of Alcohol's Effects On Adult Neurogmentioning

confidence: 99%

Alcohol and adult hippocampal neurogenesis: Promiscuous drug, wanton effects

Geil

Hayes

McClain

et al. 2014

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Adult neurogenesis is now widely accepted as an important contributor to hippocampal integrity and function but also dysfunction when adult neurogenesis is affected in neuropsychiatric diseases such as alcohol use disorders. Excessive alcohol consumption, the defining characteristic of alcohol use disorders, results in a variety of cognitive and behavioral impairments related wholly or in part to hippocampal structure and function. Recent preclinical work has shown that adult neurogenesis may be one route by which alcohol produces hippocampal neuropathology. Alcohol is a pharmacologically promiscuous drug capable of interfering with adult neurogenesis through multiple mechanisms. This review will discuss the primary mechanisms underlying alcohol-induced changes in adult hippocampal neurogenesis including alcohol's effects on neurotransmitters, CREB and its downstream effectors, and the neurogenic niche.

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Minocycline reduces ethanol drinking

Cited by 121 publications

References 20 publications

Evaluation of effect of minocycline on rewarding potential and alcohol relapse in place preference model in mice

Evaluation of effect of minocycline on rewarding potential and alcohol relapse in place preference model in mice

Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review

Alcohol and adult hippocampal neurogenesis: Promiscuous drug, wanton effects

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