Minocycline‐Induced Staining of Torus Palatinus and Alveolar Bone

Ayangco, Lilibeth; Sheridan, Phillip J.

doi:10.1902/jop.2003.74.5.669

Cited by 25 publications

(23 citation statements)

References 22 publications

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“…[9] A literature search has also shown that the onset of discoloration can occur anytime from one month to many years after the initiation of treatment. [1011] In this patient, minocycline staining of the palatal torus occurred approximately three-and-a-half years after minocycline therapy was instituted. Though clinically underlying bone appears blue or black, studies have shown that upon surgical exposure this bone has been described as being dark green,[12] dark gray-green,[13] greenish yellow[8] or gray in color.…”

Section: Discussionmentioning

confidence: 96%

Staining of palatal torus secondary to long term minocycline therapy

Buddula¹

2009

J Indian Soc Periodontol

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Minocycline and other tetracycline analogs are well known to cause discoloring of alveolar bone, teeth and other tissues. The present case reports palatine torus discoloring, in a 91-year-old patient, after long term minocycline therapy. The patient was presented with staining of the palatal torus resulting from prior minocycline use for three-and-a-half years. The diagnosis of minocycline staining of palatal torus was done during a routine hygiene examination. The patient was informed that the bluish appearance of the palatal torus was the result of long term minocycline use. The patient was not willing to discontinue the antibiotic and was not concerned about the appearance. The clinician should inform patients on long term minocycline therapy about the possible side effects of staining of the alveolar bone, teeth and other soft tissue.

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Section: Discussionmentioning

confidence: 96%

Staining of palatal torus secondary to long term minocycline therapy

Buddula¹

2009

J Indian Soc Periodontol

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“…Over the treatment period of 1.5 years, the patient developed no major side effects. Potential side effects of long-term oral minocycline include permanent staining of teeth, 17,18 pulmonary complications such as pulmonary lupus and hypersensitivity pneumonia, 19 Sweet's syndrome, 20 and lupus erythematosuslike symptoms. 21 More research is necessary to understand the pathogenesis of this disfiguring cicatricial scalp disorder and to find more efficacious and safe treatment options.…”

Section: Discussionmentioning

confidence: 99%

“…The condition occurs mostly in young and middle-aged adults, with a preference for the vertex or occipital area, and leads to scarring alopecia with a lack of follicular ostia, accompanied by diffuse and perifollicular erythema, follicular pustules, follicular tufting, and oftentimes hemorrhagic crusts and erosions. [1][2][3] Follicular tufting or tufted folliculitis is a common finding in patients with FD that is characterized by multiple hairs (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) emerging from a single dilated follicular orifice. Tufting occurs when the infundibular epithelia of a follicle is damaged and finally heals with the formation of one large, common infundibulum.…”

mentioning

confidence: 99%

Folliculitis Decalvans Developing 20 Years After Hair Restoration Surgery in Punch Grafts: Case Report

Otberg¹,

Wu²,

Kang³

et al. 2009

Dermatologic Surgery

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“…[68][69][70][71][72][73] Although cutaneous or oral mucosal pigmentation may appear regardless of the dose or duration of therapy, pigmentation generally results from long-term administration of minocycline at cumulative doses >100 g. The bones of the oral cavity are probably the most frequently affected sites of pigmentation, affecting about 10% of patients treated for more than 1 year. If treated for longer than 4 years, more than 20% of patients taking minocycline were affected.…”

Section: Pigmentationmentioning

confidence: 99%

Minocycline in Acne Vulgaris

Ochsendorf

2010

American Journal of Clinical Dermatology

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Minocycline is a semi-synthetic, second-generation tetracycline. It was introduced in 1972 and has both antibacterial and anti-inflammatory properties. Minocycline is used for a variety of infectious diseases and in acne. Even today, new indications beyond the antibacterial indications are being investigated such as its use in neurologic diseases. Formerly, minocycline was thought to have a superior efficacy in the treatment of inflammatory acne, especially with respect to antibacterial-resistant Propionibacterium acnes. A thorough review of the literature, however, shows that minocycline is not more effective in acne than other tetracyclines. Compared with first-generation tetracyclines, minocycline has a better pharmacokinetic profile, and compared with doxycycline it is not phototoxic. However, minocycline has an increased risk of severe adverse effects compared with other tetracyclines. It may induce hypersensitivity reactions affecting the liver, lung, kidneys, or multiple organs (Drug Reaction with Eosinophilia and Systemic Symptoms [DRESS] syndrome) in the first weeks of treatment and, with long-term treatment, may cause autoimmune reactions (systemic lupus erythematosus, autoimmune hepatitis). In addition, CNS symptoms, such as dizziness, are more frequent compared with other tetracyclines. Long-term treatment may induce hyperpigmentation of the skin or other organs. Resistance of P. acnes to minocycline also occurs, dependent on the prescribing behavior. Considering the aspects of efficacy, its adverse effect profile, resistance, price, and alternatives, minocycline is no longer considered the first-line antibacterial in the treatment of acne.

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Minocycline‐Induced Staining of Torus Palatinus and Alveolar Bone

Abstract: Patients on long-term minocycline therapy should be made aware of the possibility of pigmentation of bone and soft tissue that may be reversible with discontinuation of therapy; however, minocycline-induced staining of the permanent dentition may not be reversible.

Cited by 25 publications

References 22 publications

Staining of palatal torus secondary to long term minocycline therapy

Staining of palatal torus secondary to long term minocycline therapy

Folliculitis Decalvans Developing 20 Years After Hair Restoration Surgery in Punch Grafts: Case Report

Minocycline in Acne Vulgaris

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