Minocycline-induced scleral pigmentation

Minocycline-Induced Ocular Ochronosis

“…In some studies, the pigment has been permanently deposited [ 5 ]. No effect on visual acuity has been identified to date [ 3 , 4 ].…”

“…Multimodal imaging has been utilized to characterize these patterns. Scleral thickness, when evaluated with ocular coherence tomography has been noted to be normal [ 4 , 13 ]. The aforementioned conjunctival cysts have been identified via cobalt blue filter autofluorescence [ 10 ] and with yellow autofluorescence showing eosinophilic amorphous concretions [ 14 ].…”

“…One of its adverse effects includes hyperpigmentation of the skin and mucus membranes which has been described as both dose-independent [ 1 ] and dose-dependent [ 2 ]. Scleral hyperpigmentation can be permanent or may fade over time with discontinuation of the medication [ 3 , 4 ], without changes to visual acuity.…”

A rare case of minocycline induced diffuse hyperpigmentation

“…Minocycline-induced nail pigmentation is far less common compared to skin hyperpigmentation. Ocular pigmentation involving the sclera, conjunctiva, and retina is rare and does not cause visual dysfunction [3].…”