Minocycline-Induced Hyperpigmentation

Minocycline-Induced Hyperpigmentation Treated with a 755-nm Q-Switched Alexandrite Laser

“…Despite its small numbers, this report is the largest published series of minocycline‐induced pigmentation treated by laser irradiation. Several single case studies using a variety of pigment‐specific lasers have shown similar clinical effect, but lacked a comprehensive approach to treatment, with numerous different treatment protocols outlined with varying laser fluences and treatment intervals 25–30 . The most common approach to treatment involves pigment‐specific laser irradiation every 6 to 8 weeks to permit adequate time for pigment clearing and dermal recovery.…”

Minocycline-Induced Hyperpigmentation of the Tongue: Successful Treatment with the Q-Switched Ruby Laser

“…Such varied results may be attributed to the number of treatment sessions, fluence, and the specific type of MIH being treated. [11][12][13] In addition, both the Q-switched Nd:YAG (532 nm) 16 and the Q-switched alexandrite (755 nm) 20 lasers have been effective in the treatment of type 1 and 2 MIH, respectively. [12][13][14][15][16] The QSRL has been quite successful in removing both facial and leg hyperpigmentation.…”

“…Of the three studies that tested the Q-switched Nd:YAG laser (1064 nm), the only one that demonstrated satisfactory results employed eight treatment sessions 9 as opposed to one. [12][13][14][15][16] The QSRL has been quite successful in removing both facial and leg hyperpigmentation. [11][12][13] In addition, both the Q-switched Nd:YAG (532 nm) 16 and the Q-switched alexandrite (755 nm) 20 lasers have been effective in the treatment of type 1 and 2 MIH, respectively.…”

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Although the precise mechanism of this hyperpigmentation has not been firmly established, several histopathologic studies suggest that iron deposition, increased melanization, and/or deposits of minocycline degradation by-products may play important roles in the pathogenesis of this benign condition. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Although the precise mechanism of this hyperpigmentation has not been firmly established, several histopathologic studies suggest that iron deposition, increased melanization, and/or deposits of minocycline degradation by-products may play important roles in the pathogenesis of this benign condition.…”

“…MINOCYCLINE, a synthetic tetracycline commonly prescribed for the long-term treatment of acne, has recently been described as a cause of mucocutaneous pigmentation. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Although the precise mechanism of this hyperpigmentation has not been firmly established, several histopathologic studies suggest that iron deposition, increased melanization, and/or deposits of minocycline degradation by-products may play important roles in the pathogenesis of this benign condition. 5 Pigmentation, most often seen on the skin and buccal mucosa, does not appear to be dose related, and in certain instances may persist for years despite discontinuation of the drug.…”