Minocycline increases the life span and motor activity and decreases lipid peroxidation in manganese treated Drosophila melanogaster

Bonilla, Ernesto; Contreras, Rocío Brea; Medina-Leendertz, Shirley; Mora, Marylú; Villalobos, Virginia; Bravo, Yanauri

doi:10.1016/j.tox.2012.01.016

Cited by 36 publications

(11 citation statements)

References 27 publications

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“…These results are comparable to prior findings indicating alcohol‐induced lipid peroxidation in the brain [58]. According to this information, it seems that part of the damaging consequences of alcohol might be mediated by mitochondrial dysfunction and this process could likely be modulated by minocycline [59,60]. Furthermore, prior research has stated that minocycline exerts neuroprotective effects by inhibiting the development of free radicals in neurodegenerative events [60,61], and the function of minocycline as a scavenger for free radicals is evident in this form of disease [61].…”

Section: Discussionsupporting

confidence: 83%

“…According to this information, it seems that part of the damaging consequences of alcohol might be mediated by mitochondrial dysfunction and this process could likely be modulated by minocycline [59,60]. Furthermore, prior research has stated that minocycline exerts neuroprotective effects by inhibiting the development of free radicals in neurodegenerative events [60,61], and the function of minocycline as a scavenger for free radicals is evident in this form of disease [61]. Also, our study indicated that treatment of animals by 40 mg/kg of minocycline alone causes significant decrease in MDA level, when compared to alcohol alone group, (while there is not significant different when compared to control group) which confirms the protective role of minocycline against oxidative stress occurrence [56,62].…”

Section: Discussionmentioning

confidence: 52%

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The possible role of CREB‐BDNF signaling pathway in neuroprotective effects of minocycline against alcohol‐induced neurodegeneration: molecular and behavioral evidences

Motaghinejad

Mashayekh

Motevalian

et al. 2021

Fundamemntal Clinical Pharma

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Abuse of alcohol triggers neurodegeneration in human brain. Minocycline has characteristics conferring neuroprotection. Current study evaluates the role of the CREB‐BDNF signaling pathway in mediating minocycline's neuroprotective effects against alcohol‐induced neurodegeneration. Seventy adult male rats were randomly split into groups 1 and 2 that received saline and alcohol (2 g/kg/day by gavage, once daily), respectively, and groups 3, 4, 5, and 6 were treated simultaneously with alcohol and minocycline (10, 20, 30 and 40 mg/kg I.P, respectively) for 21 days. Group 7 received minocycline alone (40 mg/kg, i.p) for 21 days. Morris water maze (MWM) has been used to assess cognitive activity. Hippocampal neurodegenerative and histological parameters as well as cyclic AMP response element‐binding protein (CREB) and brain‐derived neurotrophic factor (BDNF) levels were assessed. Alcohol impaired cognition, and concurrent therapy with various minocycline doses attenuated alcohol‐induced cognition disturbances. Additionally, alcohol administration boosted lipid peroxidation and levels of glutathione in oxidized form (GSSG), tumor necrosis factor alpha (TNF‐α), interleukin 1 beta (IL‐1β), and Bax protein, while decreased reducing type of glutathione (GSH), Bcl‐2 protein, phosphorylated CREB, and BDNF levels in rat hippocampus. Alcohol also decreased the activity in the hippocampus of superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GR). In comparison, minocycline attenuated alcohol‐induced neurodegeneration; elevating expression levels of P‐CREB and BDNF and inhibited alcohol induced histopathological changes in both dentate gyrus (DG) and CA1 of hippocampus. Thus, minocycline is likely to provide neuroprotection against alcohol‐induced neurodegeneration through mediation of the P‐CREB/BDNF signaling pathway.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 52%

The possible role of CREB‐BDNF signaling pathway in neuroprotective effects of minocycline against alcohol‐induced neurodegeneration: molecular and behavioral evidences

Motaghinejad

Mashayekh

Motevalian

et al. 2021

Fundamemntal Clinical Pharma

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“…Doxocycline, broad-spectrum antibiotics of the tetracycline class, extends life span in C elegans [220] and Drosophila [221, 222]. Doxycycline suppresses tumor growth and metastasis in mice [223, 224].…”

Section: Doxocyclinementioning

confidence: 99%

From rapalogs to anti-aging formula

Blagosklonny¹

2017

Oncotarget

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Inhibitors of mTOR, including clinically available rapalogs such as rapamycin (Sirolimus) and Everolimus, are gerosuppressants, which suppress cellular senescence. Rapamycin slows aging and extends life span in a variety of species from worm to mammals. Rapalogs can prevent age-related diseases, including cancer, atherosclerosis, obesity, neurodegeneration and retinopathy and potentially rejuvenate stem cells, immunity and metabolism. Here, I further suggest how rapamycin can be combined with metformin, inhibitors of angiotensin II signaling (Losartan, Lisinopril), statins (simvastatin, atorvastatin), propranolol, aspirin and a PDE5 inhibitor. Rational combinations of these drugs with physical exercise and an anti-aging diet (Koschei formula) can maximize their anti-aging effects and decrease side effects.

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“…However, supplementation with high doses of minerals generally decreases organismal lifespan. Supplementation with various doses of selenium (Se), iron (Fe), manganese (Mn), copper (Cu), or zinc (Zn) leads to reduced lifespan in D. melanogaster and C. elegans (Hornsby & Harris, 1987 ; Wang et al ., 2007 ; Hu et al ., 2008 ; Bahadorani et al ., 2010 ; Helmcke et al ., 2010 ; Bonilla et al ., 2012 ; Selman et al ., 2013 ). Overexpression of metal-responsive transcription factor, MTF-1, rescues the reduced lifespan of flies induced after supplementation with high, millimolar doses of metals (Bahadorani et al ., 2010 ).…”

Section: Effects Of Vitamins and Minerals On Agingmentioning

confidence: 99%

Effects of nutritional components on aging

et al. 2014

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Nutrients including carbohydrates, proteins, lipids, vitamins, and minerals regulate various physiological processes and are essential for the survival of organisms. Reduced overall caloric intake delays aging in various organisms. However, the role of each nutritional component in the regulation of lifespan is not well established. In this review, we describe recent studies focused on the regulatory role of each type of nutrient in aging. Moreover, we will discuss how the amount or composition of each nutritional component may influence longevity or health in humans.

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Minocycline increases the life span and motor activity and decreases lipid peroxidation in manganese treated Drosophila melanogaster

Cited by 36 publications

References 27 publications

The possible role of CREB‐BDNF signaling pathway in neuroprotective effects of minocycline against alcohol‐induced neurodegeneration: molecular and behavioral evidences

The possible role of CREB‐BDNF signaling pathway in neuroprotective effects of minocycline against alcohol‐induced neurodegeneration: molecular and behavioral evidences

From rapalogs to anti-aging formula

Effects of nutritional components on aging

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