Minocycline, focus on mechanisms of resistance, antibacterial activity, and clinical effectiveness: Back to the future

Asadi, Arezoo; Abdi, Milad; Kouhsari, Ebrahim; Panahi, Pegah; Sholeh, Mohammad; Sadeghifard, Nourkhoda; Amiriani, Taghi; Ahmadi, Alireza; Maleki, Afshin; Gholami, Mehrdad

doi:10.1016/j.jgar.2020.01.022

Cited by 40 publications

(25 citation statements)

References 137 publications

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“…Typhi to trimethoprim/sulfamethoxazole was observed [ 48 ]. Minocycline has been an effective anti-MDR antibacterial for over the past 30 years [ 49 ]. In contrast to our results, a study from South Korea reported resistance of 30 strains of Salmonella spp.…”

Section: Discussionmentioning

confidence: 99%

Detection of multidrug-resistant Salmonella enterica subsp. enterica serovar Typhi isolated from Iraqi subjects

Salman¹,

Abdulmohsen²,

Falih³

et al. 2021

Vet World

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Background and Aim: Enteric fever initiated by Salmonella enterica subsp. enterica serovar Typhi (S. Typhi) is among the most consistent disease worldwide, particularly in developing countries. The present study aimed to isolate and identify S. Typhi from typhoid suspected patients and determine their antibacterial susceptibility testing. Materials and Methods: Thirty blood samples were collected from typhoid suspected patients in Baghdad, Iraq. The samples were cultured on SS agar and XLD agar for screening of S. Typhi. The suspected colonies were picked up and subjected to Vitek 2 compact for biochemical identification and antibacterial susceptibility testing of the organisms. Molecular identification of the isolates was performed by real-time polymerase chain reaction (RT-PCR). Results: Black colonies were observed on cultured plates. Out of 30 samples, 27 and 29 isolates were identified as S. Typhi using Vitek 2 compact and RT-PCR, respectively. The data of the present study revealed that the strains of S. Typhi were showing multidrug resistance. All S. Typhi strains exhibited resistance to penicillins (ticarcillin and piperacillin), cephalosporins 4th G (cefepime), and monobactam (aztreonam). However, all the strains showed susceptibility against carbapenems (imipenem and meropenem) and tetracycline (minocycline). Conclusion: RT-PCR and Vitek 2 compact showed a high level of accuracy in the detection of S. Typhi. Multidrug resistance was observed, which is an alert for the reduction of antibiotic consumption.

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Section: Discussionmentioning

confidence: 99%

Detection of multidrug-resistant Salmonella enterica subsp. enterica serovar Typhi isolated from Iraqi subjects

Salman¹,

Abdulmohsen²,

Falih³

et al. 2021

Vet World

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“…Minocycline (MIN) is a second-generation semi-synthetic tetracycline analog that is widely used in clinical settings ( Asadi et al, 2020 ). It exhibits a high degree of fat solubility, and can readily pass through the blood-brain barrier ( Yong et al, 2004 ).…”

Section: Introductionmentioning

confidence: 99%

Antifungal Activity of Minocycline and Azoles Against Fluconazole-Resistant Candida Species

et al. 2021

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Candida species are the most common fungal pathogens to infect humans, and can cause life-threatening illnesses in individuals with compromised immune systems. Fluconazole (FLU) is the most frequently administered antifungal drug, but its therapeutic efficacy has been limited by the emergence of drug-resistant strains. When co-administered with minocycline (MIN), FLU can synergistically treat clinical Candida albicans isolates in vitro and in vivo. However, there have been few reports regarding the synergistic efficacy of MIN and azoles when used to treat FLU-resistant Candida species, including Candida auris. Herein, we conducted a microdilution assay wherein we found that MIN and posaconazole (POS) showed the best in vitro synergy effect, functioning against 94% (29/31) of tested strains, whereas combinations of MIN+itraconazole (ITC), MIN+voriconazole (VOR), and MIN+VOR exhibited synergistic activity against 84 (26/31), 65 (20/31), and 45% (14/31) of tested strains, respectively. No antagonistic activity was observed for any of these combinations. In vivo experiments were conducted in Galleria mellonella, revealing that combination treatment with MIN and azoles improved survival rates of larvae infected with FLU-resistant Candida. Together, these results highlight MIN as a promising synergistic compound that can be used to improve the efficacy of azoles in the treatment of FLU-resistant Candida infections.

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“…Nevertheless, concerns could be raised that a prolonged anti-biotic administration in patients with psychiatric disorders could lead to the emergence of antibiotic-resistant bacteria. Minocycline has an overall low propensity to produce antibiotic-resistance ( Soczynska et al., 2012 ), but evidence of resistance to this antibiotic, together with resistance mechanisms, have been described ( Asadi et al., 2020 ). Overall, little is known about the development of antibiotic-resistance in patients with psychiatric conditions, where no specific bacteria are targeted by minocycline.…”

Section: Discussionmentioning

confidence: 99%

Minocycline in Major Depressive Disorder: And overview with considerations on treatment-resistance and comparisons with other psychiatric disorders

Nettis

2021

Brain, Behavior, & Immunity - Health

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Evidence on the link between the immune system and Major Depressive Disorder (MDD) has led to explore antidepressant properties of anti-inflammatory drugs. Among these, minocycline has been identified as a potential novel treatment for MDD, in particular for treatment-resistant depression. The aim of the current paper is to review current pre-clinical and clinical evidence on the antidepressant efficacy of minocycline. The review includes considerations on the role of both peripheral and central inflammation in the response to minocycline and comparisons of minocycline efficacy across different psychiatric disorders (i.e., unipolar depression, bipolar depression, and schizophrenia).

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Minocycline, focus on mechanisms of resistance, antibacterial activity, and clinical effectiveness: Back to the future

Cited by 40 publications

References 137 publications

Detection of multidrug-resistant Salmonella enterica subsp. enterica serovar Typhi isolated from Iraqi subjects

Detection of multidrug-resistant Salmonella enterica subsp. enterica serovar Typhi isolated from Iraqi subjects

Antifungal Activity of Minocycline and Azoles Against Fluconazole-Resistant Candida Species

Minocycline in Major Depressive Disorder: And overview with considerations on treatment-resistance and comparisons with other psychiatric disorders

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