Minocycline exerts a neuroprotective action against 6-OHDA-induced neurotoxicity: in vivo and in vitro studies

Abstract

Background: Parkinson's disease (PD) is a chronic neurological disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. The oxidative stress and inflammation, among other factors, are involved in the mechanisms of cell death in PD. We studied the neuroprotective properties of minocycline (Mino), focusing on its behavioral, neurochemical and immunohistochemical effects. Besides, Mino effects were also studied on an in vitro model of PD, as well as on the release of MPO in human neutrophils, and also its antioxidant activity.