Minocycline Effectively Protects the Rabbit’s Spinal Cord From Aortic Occlusion-Related Ischemia

Drenger, Benjamin; Fellig, Yakov; Ben-David, Dror; Mintz, Bella; Idrees, Suhel; Or, Omer; Kaplan, Leon; Ginosar, Yehuda; Barzilay, Yair

doi:10.1053/j.jvca.2015.11.003

Journal of Cardiothoracic and Vascular Anesthesia

2016

DOI: 10.1053/j.jvca.2015.11.003

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Minocycline Effectively Protects the Rabbit’s Spinal Cord From Aortic Occlusion-Related Ischemia

Benjamin Drenger¹,

Yakov Fellig

Dror Ben-David

et al.

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Cited by 6 publications

(2 citation statements)

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“… 8 , 9 Several approaches to overcome neuronal damage in the spinal cord after ischemia/reperfusion have been attempted. 4 , 10 , 11 , 12 However, there are few comprehensive reports on the protein profile of spinal cord ischemia and the subsequent targeting of neuroprotective agents against this ischemic damage.…”

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Tat-protein disulfide-isomerase A3: a possible candidate for preventing ischemic damage in the spinal cord

et al. 2017

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In the present study, we searched for possible candidates that can prevent ischemic damage in the rabbit spinal cord. For this study, we used two-dimensional gel electrophoresis followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, in sham- and ischemia-operated animals. As the level of protein disulfide-isomerase A3 (PDIA3) significantly decreased 3 h after ischemia/reperfusion, we further investigated its possible role against ischemic damage using an in vitro spinal cord cell line and in vivo spinal cord ischemic model. The administration of Tat-PDIA3 significantly reduced the hydrogen peroxide-induced formation of reactive oxygen species and cell death, based on terminal deoxynucleotidyl transferase-mediated biotinylated dUTP nick end labeling and a colorimetric WST-1 assay. Further, Tat-PDIA3 significantly ameliorated the ischemia-induced deficits in motor function, based on Tarlov’s criteria, 24–72 h after ischemia/reperfusion, as well as the degeneration of motor neurons in the ventral horn 72 h after ischemia/reperfusion. Tat-PDIA3 administration also reduced the ischemia-induced activation of microglia and lipid peroxidation in the motor neurons 72 h after ischemia/reperfusion. PDIA3 also potentially ameliorated the ischemia-induced increase in oxidative markers in serum and decreased the activity of Cu,Zn-superoxide dismutase, Mn-superoxide dismutase, and glutathione peroxidase in spinal cord homogenates, 24 h and 72 h after ischemia/reperfusion. These results suggest that Tat-PDIA3 could be used to protect spinal cord neurons from ischemic damage, due to its modulatory action on the oxidative/anti-oxidative balance. Tat-PDIA3 could be applicable to protects neurons from the ischemic damage induced by thoracoabdominal aorta obstruction.

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Tat-protein disulfide-isomerase A3: a possible candidate for preventing ischemic damage in the spinal cord

et al. 2017

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“…Earlier work in mice and rabbits also indicates that minocycline is protective after ischemic injury secondary to temporary interruption of cord blood supply. 10,11 In the setting of a limited, predictable decrease in spinal cord perfusion, a single prophylactic dose of minocycline seems logical because temporary astrocytosis inhibition and other anti-inflammatory effects may prevent secondary neuronal injury after the initial ischemic insult. Are Drenger's findings therefore limited to early-onset SCI secondary to temporary interruptions of spinal cord perfusion?…”

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Can Minocycline Become the Magic Pill of Spinal Cord Protection?

Frogel

Zahavi

2019

Journal of Cardiothoracic and Vascular Anesthesia

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Maternal Minocycline as Fetal Therapy in a Rat Model of Myelomeningocele

Biancotti,

Sescleifer,

Sferra

et al. 2024

Journal of Surgical Research

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Minocycline Effectively Protects the Rabbit’s Spinal Cord From Aortic Occlusion-Related Ischemia

Cited by 6 publications

References 53 publications

Tat-protein disulfide-isomerase A3: a possible candidate for preventing ischemic damage in the spinal cord

Tat-protein disulfide-isomerase A3: a possible candidate for preventing ischemic damage in the spinal cord

Can Minocycline Become the Magic Pill of Spinal Cord Protection?

Maternal Minocycline as Fetal Therapy in a Rat Model of Myelomeningocele

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