Minocycline but not valproic acid influence the density of NogoA-immunoreactive neurons in the hilus of the dentate gyrus of the rats subjected to intracerebral haematoma

Majak, Katarzyna; Domaradzka-Pytel, B; Kowiański, Przemysław; Moryś, Janusz

doi:10.5603/fm.2014.0044

Cited by 5 publications

(9 citation statements)

References 43 publications

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“…Although these observations were consistent across injections, many of the regions we observed also project to the nearby piriform and endopiriform cortex (Majak & Moryś, 2007;Neville & Haberly, 2004).…”

Section: The Mouse Pl Receives Major Input From the Main Olfactory Ne...supporting

confidence: 55%

Neuronal Subtypes and Connectivity of the Adult Mouse Paralaminar Amygdala

Saxon,

Alderman,

Sorrells

et al. 2024

eNeuro

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The paralaminar nucleus of the amygdala (PL) comprises neurons that exhibit delayed maturation. PL neurons are born during gestation but mature during adolescent ages, differentiating into excitatory neurons. These late-maturing PL neurons contribute to the increase in size and cell number of the amygdala between childhood and adulthood. However, the function of the PL upon maturation is unknown, as the region has only recently begun to be characterized in detail. In this study, we investigated key defining features of the adult mouse PL; the intrinsic morpho-electric properties of its neurons, and its input and output circuit connectivity. We identify two subtypes of excitatory neurons in the PL based on unsupervised clustering of electrophysiological properties. These subtypes are defined by differential action potential firing properties and dendritic architecture, suggesting divergent functional roles. We further uncover major axonal inputs to the adult PL from the main olfactory network and basolateral amygdala. We also find that axonal outputs from the PL project reciprocally to these inputs, and to diverse targets including the amygdala, frontal cortex, hippocampus, hypothalamus, and brainstem. Thus, the adult PL is centrally placed to play a major role in the integration of olfactory sensory information, likely coordinating affective and autonomic behavioral responses to salient odor stimuli.Significance StatementMammalian amygdala development includes a growth period from childhood to adulthood, believed to support emotional and social learning. This amygdala growth is partly due to the maturation of neurons during adolescence in the paralaminar amygdala (PL). However, the functional properties of these neurons are unknown. In our previous studies, we characterized the paralaminar amygdala in the adolescent mouse. Here, we investigate the properties of the adult PL in the mouse, revealing the existence of two neuronal subtypes that may play distinct functional roles in the adult brain. We further reveal the brain-wide input and output connectivity of the PL, indicating that the PL integrates olfactory cues for emotional processing and delivers information to regions associated with reward and autonomic states.

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Section: The Mouse Pl Receives Major Input From the Main Olfactory Ne...supporting

confidence: 55%

Neuronal Subtypes and Connectivity of the Adult Mouse Paralaminar Amygdala

Saxon,

Alderman,

Sorrells

et al. 2024

eNeuro

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“…Interestingly, a non-circumscribed anatomical region termed 'area tempestas' traditionally described within the deep piriform cortex (primary olfactory) demonstrates strikingly similar kindling results (Löscher et al, 1995). Upon further research, the dorsal endopiriform (rodents) and preendopiriform (human) nuclei (i.e., ventral claustrum) correspond to this physiologically defined area (see Majak and Moryś, 2007;Vaughan and Jackson, 2014 for review).…”

Section: A Case For Involvement Of the Claustrum In Impaired Awarenes...mentioning

confidence: 79%

Is there room in epilepsy for the claustrum?

Watson,

Meletti,

Mahavadi

et al. 2024

Front. Syst. Biol.

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The function of the claustrum and its role in neurological disorders remains a subject of interest in the field of neurology. Given the claustrum’s susceptibility to seizure-induced damage, there is speculation that it could serve as a node in a dysfunctional epileptic network. This perspective article aims to address a pivotal question: Does the claustrum play a role in epilepsy? Building upon existing literature, we propose the following hypotheses for the involvement of the claustrum in epilepsy: (1) Bilateral T2/FLAIR magnetic resonance imaging (MRI) hyperintensity of the claustrum after status epilepticus represents a radiological phenomenon that signifies inflammation-related epileptogenesis; (2) The ventral claustrum is synonymous with a brain area known as ‘area tempestas,’ an established epileptogenic center; (3) The ventral subsector of the claustrum facilitates seizure generalization/propagation through its connections with limbic and motor-related brain structures; (4) Disruption of claustrum connections during seizures might contribute to the loss of consciousness observed in impaired awareness seizures; (5) Targeting the claustrum therapeutically could be advantageous in seizures that arise from limbic foci. Together, evidence from both clinical case reports and animal studies identify a significant role for the ventral claustrum in the generation, propagation, and intractable nature of seizures in a subset of epilepsy syndromes.

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“…The DEn is reciprocally connected with the piriform cortex and several other cortical formations [31,37,46]. These projections are largely excitatory and might provide a substrate for regenerative feedback interactions.…”

Section: Discussionmentioning

confidence: 99%

“…Convergence of information from different levels of the olfactory system and from the amygdala occurs in the DEn. In addition, electrical and optical recordings indicate that olfactory and gustatory activity converges onto single neurons of the DEn [36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Degenerative Changes in the Claustrum and Endopiriform Nucleus after Early-Life Status Epilepticus in Rats

Druga,

Mares,

Salaj

et al. 2024

IJMS

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The aim of the present study was to analyze the location of degenerating neurons in the dorsal (insular) claustrum (DCL, VCL) and the dorsal, intermediate and ventral endopiriform nucleus (DEn, IEn, VEn) in rat pups following lithium–pilocarpine status epilepticus (SE) induced at postnatal days [P]12, 15, 18, 21 and 25. The presence of Fluoro-Jade B-positive neurons was evaluated at 4, 12, 24, 48 h and 1 week later. A small number of degenerated neurons was observed in the CL, as well as in the DEn at P12 and P15. The number of degenerated neurons was increased in the CL as well as in the DEn at P18 and above and was highest at longer survival intervals. The CL at P15 and 18 contained a small or moderate number of degenerated neurons mainly close to the medial and dorsal margins also designated as DCl (“shell”) while isolated degenerated neurons were distributed in the VCl (“core”). In P21 and 25, a larger number of degenerated neurons occurred in both subdivisions of the dorsal claustrum. The majority of degenerated neurons in the endopiriform nucleus were found in the intermediate and caudal third of the DEn. A small number of degenerated neurons was dispersed in the whole extent of the DEn with prevalence to its medial margin. Our results indicate that degenerated neurons in the claustrum CL and endopiriform nucleus are distributed mainly in subdivisions originating from the ventral pallium; their distribution correlates with chemoarchitectonics of both nuclei and with their intrinsic and extrinsic connections.

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Minocycline but not valproic acid influence the density of NogoA-immunoreactive neurons in the hilus of the dentate gyrus of the rats subjected to intracerebral haematoma

Abstract: (Folia Morphol 2014; 73, 3: 279-285)

Cited by 5 publications

References 43 publications

Neuronal Subtypes and Connectivity of the Adult Mouse Paralaminar Amygdala

Neuronal Subtypes and Connectivity of the Adult Mouse Paralaminar Amygdala

Is there room in epilepsy for the claustrum?

Degenerative Changes in the Claustrum and Endopiriform Nucleus after Early-Life Status Epilepticus in Rats

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