Minocycline attenuates lipopolysaccharide-induced locomotor deficit and anxiety-like behavior via upregulation of the BDNF/CREB protein expression in the rat medial prefrontal cortex (mPFC)
Abstract:Introduction: Neuroinflammation following lipopolysaccharide (LPS) administration induces locomotor deficit and anxiety-like behavior. In this study, minocycline was compared to memantine, the NMDA receptor antagonist, for its effects on LPS-induced locomotor deficit and anxiety-like behavior in rats. Methodology: Adult male Sprague Dawley rats were administered either two different doses of minocycline (25 or 50 mg/kg/day, i.p.) or 10 mg/kg/day of memantine (i.p.) for 14 days four days prior to LPS (5 mg/kg, … Show more
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