Minocycline attenuates cholinergic dysfunction and neuro-inflammation-mediated cognitive impairment in scopolamine-induced Alzheimer’s rat model

Amirahmadi, Sabiheh; Farimani, Faezeh Dabouri; Akbarian, Mahsan; Mirzavi, Farshad; Ghalibaf, Mohammad Hossein Eshaghi; Rajabian, Arezoo; Hosseini, Mahmoud

doi:10.1007/s10787-022-01071-2

Cited by 16 publications

(11 citation statements)

References 29 publications

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“…One of the important characteristics of the scopolamine model of AD is neuroinflammation, which may result from or contribute to the formation of oxidative stress . The reported studies revealed by Amirahmadi et al that pro-inflammatory cytokines TNF- α , IL-1 β , and IL-6, which have been associated with significant neuropathological alterations in neurodegenerative disorders, were much more expressed when scopolamine was administered . Similarly, Cheon et al.…”

Section: Resultsmentioning

confidence: 99%

“…18 The reported studies revealed by Amirahmadi et al that pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, which have been associated with significant neuropathological alterations in neurodegenerative disorders, were much more expressed when scopolamine was administered. 19 Similarly, Cheon et al also found that pro-inflammatory cytokines like IL-1β, IL-18, and TNF-α as well as inflammasome components like NLRP3, ASC, and caspase-1 were present in higher amounts in male C57BL/6 mice treated with intraperitoneal scopolamine. 20 In this research, we analyzed the hippocampus derived from scopolamine-induced neuroinflammation-grade mice by four-dimensional label-free quantification-based proteomics to examine at a consensus understanding of the proteomic changes that take place in the brain when the oral administration of YVLLPSPK in alleviating memory impairment.…”

Section: ■ Statistical Analysismentioning

confidence: 90%

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Insights into the Hippocampus Proteomics Reveal Epigenetic Properties of Walnut-Derived Peptides in a Low-Grade Neuroinflammation Model

Zhao

Bordoni

Min

et al. 2023

J. Agric. Food Chem.

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Epigenetic mechanisms that dysregulate gene expressions may play a significant role in the development of neurological disorders. However, whether peptides can modulate epigenetic mechanisms remains elusive. This work aimed to investigate the impact of pretreatment with walnut-derived peptidesWHP and YVLLPSPKon DNA methylation in a low-grade neuroinflammation model. The enriched KEGG pathways included oxidative phosphorylation, riboflavin metabolism, ribosome, and pyrimidine metabolism, which are associated with methylation modification by oral administration of YVLLPSPK in mice with scopolamine-induced cognitive deficits. Furthermore, when THP-1 cells (human acute monocytic leukemia cell line) were exposed to lipopolysaccharide (LPS)-induced inflammation responses, both WHP and YVLLPSPK markedly inhibited the level of Il-6 to 2.05 ± 0.76 and 1.29 ± 0.19 (p < 0.05) and also declined the mRNA expression of Mcp-1 to 1.64 ± 0.02 and 3.29 ± 1.21 (p < 0.01), respectively. Meanwhile, YVLLPSPK decreased the activities of DNA methyltransferases (DNMTs) to 1.03 ± 0.02 and 1.20 ± 0.31 (p < 0.05) based on Dnmt3b and Tet2, respectively. The results indicated that YVLLPSPK modulated DNA methylation in embryonic and neural precursor cells in creating new methylation patterns. Further trials are needed to assess the mechanisms underlying DNA methylation changes through peptides in the pathophysiology of neurological disorders.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Statistical Analysismentioning

confidence: 90%

Insights into the Hippocampus Proteomics Reveal Epigenetic Properties of Walnut-Derived Peptides in a Low-Grade Neuroinflammation Model

Zhao

Bordoni

Min

et al. 2023

J. Agric. Food Chem.

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“…One unit of CAT activity is defined as the amount of SOD concentration degrading H 2 O 2 per minute. The reduction in absorbance was monitored using an UV–visible spectrophotometer at 240 nm per min 22,26 …”

Section: Methodsmentioning

confidence: 99%

“…The reduction in absorbance was monitored using an UV-visible spectrophotometer at 240 nm per min. 22,26…”

Section: Enzymatic Antioxidant Systemsmentioning

confidence: 99%

Zataria multiflora and its constituent, carvacrol, counteract sepsis‐induced aortic and cardiac toxicity in rat: Involvement of nitric oxide and oxidative stress

Hosseini

Arab

Beheshti

et al. 2023

Anim Models and Exp Med

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Background: Zataria multiflora and carvacrol showed various pharmacological properties including anti-inflammatory and anti-oxidant effects. However, up to now no studies have explored its potential benefits in ameliorating sepsis-induced aortic and cardiac injury. Thus, this study aimed to investigate the effects of Z. multiflora and carvacrol on nitric oxide (NO) and oxidative stress indicators in lipopolysaccharide (LPS)-induced aortic and cardiac injury.Methods: Adult male Wistar rats were assigned to: Control, lipopolysaccharide (LPS)(1 mg/kg, intraperitoneal (i.p.)), and Z. multiflora hydro-ethanolic extract (ZME, 50-200 mg/kg, oral)-and carvacrol (25-100 mg/kg, oral)-treated groups. LPS was injected daily for 14 days. Treatment with ZME and carvacrol started 3 days before LPS administration and treatment continued during LPS administration. At the end of the study, the levels of malondialdehyde (MDA), NO, thiols, and antioxidant enzymes were evaluated. Results:Our findings showed a significant reduction in the levels of superoxide dismutase (SOD), catalase (CAT), and thiols in the LPS group, which were restored by ZME and carvacrol. Furthermore, ZME and carvacrol decreased MDA and NO in cardiac and aortic tissues of LPS-injected rats. Conclusions:The results suggest protective effects of ZME and carvacrol on LPSinduced cardiovascular injury via improved redox hemostasis and attenuated NO production. However, additional studies are needed to elucidate the effects of ZME and its constituents on inflammatory responses mediated by LPS.

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“…A recent investigation reported the impact of minocycline on cognitive parameters in diabetic rats, using passive avoidance and elevated plus maze tests. Moreover, It also revealed that minocycline modified AChE, glutathione, pro-inflammatory cytokines, and histopathological changes [ [12] , [13] ]. Administration of scopolamine, an antagonist of the muscarinic cholinergic receptor, has been associated with memory and learning impairment; therefore, the scopolamine-induced animal model is widely used as a pharmacological model for inducing dementia [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Minocycline alleviated scopolamine-induced amnesia by regulating antioxidant and cholinergic function

Ghalibaf¹,

Rajabian²,

Parviz³

et al. 2023

Heliyon

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Minocycline attenuates cholinergic dysfunction and neuro-inflammation-mediated cognitive impairment in scopolamine-induced Alzheimer’s rat model

Cited by 16 publications

References 29 publications

Insights into the Hippocampus Proteomics Reveal Epigenetic Properties of Walnut-Derived Peptides in a Low-Grade Neuroinflammation Model

Insights into the Hippocampus Proteomics Reveal Epigenetic Properties of Walnut-Derived Peptides in a Low-Grade Neuroinflammation Model

Zataria multiflora and its constituent, carvacrol, counteract sepsis‐induced aortic and cardiac toxicity in rat: Involvement of nitric oxide and oxidative stress

Minocycline alleviated scopolamine-induced amnesia by regulating antioxidant and cholinergic function

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