Minocycline-Associated Tooth Staining

Abstract

OBJECTIVE: To describe a case of tooth discoloration in an adult after minocycline treatment for arthritis. CASE SUMMARY: A 68-year-old white woman presented with blue–black staining of her lower anterior teeth after 4 months of minocycline therapy for arthritis. Her other medications are not known to cause discoloration of teeth. While the patient continued taking minocycline, her dentist was not able to remove the discoloration. Within 1 month after discontinuation of the minocycline, the dentist was able to remove the discoloration entirely. DISCUSSION: Minocycline, a synthetic derivative of tetracycline, has been shown to cause abnormal pigmentation of the skin, thyroid gland, nails, bone, sclera, and conjunctiva in adults. It also has been shown to cause tooth discoloration in a few patients. This case is unusual in that the tooth discoloration disappeared after discontinuing minocycline therapy. CONCLUSIONS: This complication of minocycline is more commonly thought of in the pediatric population. However, clinicians need to be aware of this adverse drug reaction, as this agent may be used increasingly in the treatment of adults with arthritis.

Tooth Discoloration After Treatment with Linezolid

“…25 Staining of the teeth is thought to be due to the formation of a tetracycline-calcium orthophosphate complex during tooth development. 26 The staining tends to worsen over time due to an ongoing photochemical reaction involving the tetracycline crystals embedded in the crystalline structure of the teeth. 25 Our patient' s adverse effect was not permanent; manual descaling of her teeth removed the discoloration entirely, with no recurrence.…”

Tooth Discoloration of Immature Permanent Incisor Associated with Triple Antibiotic Therapy: A Case Report

“…The mean changes for each parameter in the different experimental periods are depicted in Figs. [8][9][10][11]. The changes in brightness DL* were significantly different in the 3 groups (P < .05).…”

“…However, the disadvantages of this mixture are not well-known. Among the components of the mixture, minocycline, a derivative of tetracycline, can induce tooth discoloration after long-term oral use (10)(11)(12)(13). Kim et al (14) suggested that Ledermix (Haupt Pharma GmbH, Wolfratshausen, Germany) paste introduced in the canal might cause discoloration of teeth, and that such effects might be due to the demeclocycline in the Ledermix paste.…”

Black thyroid

“…Apart from black coloration of the thyroid, pigment changes of the skin, nails, teeth, blood vessels, heart valves, and bones have also been reported in patients chronically taking minocycline [3,5,8,12]. In addition, black discoloration phenomena of other organs in the course of natural diseases, such as "black esophagus" [14], may occasionally be observed at autopsy.…”