Minocycline abrogates individual differences in nerve injury-evoked affective disturbances in male rats and prevents associated supraspinal neuroinflammation
Jayden A. O’Brien,
Paul J. Austin
Abstract:Chronic neuropathic pain precipitates a complex range of affective and behavioural disturbances that differ markedly between individuals. While the reasons for differences in pain-related disability are not well understood, supraspinal neuroimmune interactions are implicated. Minocycline has antidepressant effects in humans and attenuates affective disturbances in rodent models of pain, and acts act by reducing neuroinflammation in both the spinal cord and brain. Previous studies, however, tend not to investig… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.