Mink with Aleutian disease have autoantibodies to some autoantigens

Mourit­sen, Søren; Aasted, Bent; Høier‐Madsen, Mimi

doi:10.1016/0165-2427(89)90120-7

Cited by 6 publications

(1 citation statement)

References 14 publications

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“…Thus, reduced removal of immune complexes by mesangial cells as considered by PRIEUR et al (1972) may result in the detection of viral antigen in aa-mink and its failure in non-Aleutian mink. Finally, several other components such as autoantibodies to double-stranded DNA, rheumatoid factors and antibodies to thyroglobulin are significantly elevated in ADV-infected mink (MOURITSEN et al, 1989) and have to be considered as potential components in pathogenic immune complexes.…”

Section: Discussionmentioning

confidence: 99%

Antigen Distribution in Organs of Mink with Aleutian Disease Parvovirus Infection

Wohlsein

Trautwein

Stolze

et al. 1990

Journal of Veterinary Medicine, Series B

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Summary On tissues from naturally infected non‐Aleutian mink an immunohistological study was performed using monoclonal antibodies and the immunoperoxidase method. Structural proteins of ADV were demonstrated in cryosections and in ethanol‐fixed and paraffin‐embedded material which provide antigen detection in a similar amount together with good histological structure. In lymphoid organs viral antigen was restricted to B‐cell areas, particularly lymphoid follicles. The pattern of antigen distribution was typical for follicular dendritic cells which are capable to retain immune complexes. Beside macrophages in the interior of lymphoid follicles most likely proliferating B‐lymphoblasts reveal nuclear and cytoplasmatic presence of structural proteins indicating viral replication. Cells of the mononuclear phagocyte system such as cells of lymphatic sinuses and hepatic Kupffer cells harbor viral protein in the cytoplasm, probably resulting from phagocytosis of immune complexes. Renal glomeruli were consistently negative for virus antigen whereas in interstitial infiltrates cells resembling macrophages stained positive for ADV structural proteins.

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Section: Discussionmentioning

confidence: 99%