Minireview:Malasseziainfections in immunocompromised patients

Abstract

SummaryMalassezia spp. form part of the normal human cutaneous flora and are implicated in several mild, but recurrent cutaneous diseases, such as pityriasis versicolor, Malassezia folliculitis, seborrhoeic dermatitis, and, with lesser frequency, a range of other dermatological disorders. Malassezia spp. have also been associated with cutaneous and systemic diseases in immunocompromised patients including folliculitis, seborrhoeic dermatitis, catheter-related fungaemia and a variety of deeply invasive infections. In this review, we provide an overview of the epidemiology, risk factors, pathogenesis, clinical manifestations, diagnosis, treatment and outcome of cutaneous and invasive Malassezia infections in immunocompromised patients.

Malassezia pachydermatis fungemia in a preterm neonate resistant to fluconazole and flucytosine

“…are known etiologic agents of pityriasis versicolor and are normally present on skin without clinical manifestations [1–3]. However, in view of their close association with human skin, M. furfur and some other species of the genus may cause systemic infection, particularly in severely ill patients receiving TPN with lipid enrichment [3]. Although, M. pachydermatis does not require lipid supplementation for growth, it is lipophilic and like other members of the genus, has the potential to cause systemic infection in preterm neonates and adults [1,8,13,14].…”

Antifungal Susceptibility Testing of Malassezia spp. with an Optimized Colorimetric Broth Microdilution Method

“…Malassezia is the most common fungal genus of the healthy human skin microbiome (2). Additionally, a pathogenic role is attributed to these yeasts in common skin diseases such as pityriasis versicolor, atopic dermatitis, and seborrheic dermatitis, and they can cause severe systemic infections in neonates and immunocompromised individuals (3,4).…”

Fungal Diversity in Gut Microbiota in Patients with Cancer

“…For instance member of Malassezia spp. have shown to cause folliculitis in immunocompromised patients resulting from diabetes, haematological malignancies, bonemarrow transplant, and AIDS (Alpert et al, 1987, Ashbee, 2007 (Tragiannidis et al, 2010). Many other fungi, such as members of Saccharomyces, Debaromyces, Galactomyces, Cryptococcus and Rhodotorula and molds such as Aspergillus and Pencillium were recovered from various fecal samples in our study.…”