Miniplates coated by plasma electrolytic oxidation improve bone healing of simulated femoral fractures on low bone mineral density rats

Momesso, Gustavo Antônio Corrêa; Polo, Tárik Ocon Braga; Silva, William Phillip Pereira da; Barbosa, Stéfany; Freitas, Gileade Pereira; Lopes, Helena Bacha; Cordeiro, Jairo M.; Toro, Luan Felipe; Chiba, Fernando Yamamoto; Matsushita, Dóris Hissako; Louzada, Mário Jefferson Quirino; Cruz, Nilson Cristino da; Barão, Valentim Adelino Ricardo; Faverani, Leonardo Pérez

doi:10.1016/j.msec.2020.111775

Cited by 10 publications

(8 citation statements)

References 42 publications

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“…Plasma electrolytic oxidation (PEO) is a method of choice to supply artificial dental/bone implants with bioactive surfaces to improve postoperative healing and long-term stability. , Indeed, PEO-generated surfaces have been shown to increase osseointegration , and possess antibacterial properties. , Moreover, PEO surface layers can increase the corrosion of implants, especially with biodegradable materials such as Mg alloys . PEO processing could be especially useful for implants in patients with low bone mineral density (osteoporosis) and other medical conditions . PEO was also used to synthesize a bioactive glass-based coating on titanium (Ti) implants that enhanced their tribological properties with greater corrosion resistance .…”

Section: Introductionmentioning

confidence: 99%

“…9 PEO processing could be especially useful for implants in patients with low bone mineral density (osteoporosis) and other medical conditions. 10 PEO was also used to synthesize a bioactive glass-based coating on titanium (Ti) implants that enhanced their tribological properties with greater corrosion resistance. 11 PEO was also used to enhance anticorrosive properties of low-carbon steel pipes in the shipping industry.…”

Section: Introductionmentioning

confidence: 99%

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Nitrilotriacetic Acid Improves Plasma Electrolytic Oxidation of Titanium for Biomedical Applications

Kyrylenko

Sowa

Kazek-Kęsik

et al. 2023

ACS Appl. Mater. Interfaces

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Dental implants have become a routine, affordable, and highly reliable technology to replace tooth loss. In this regard, titanium and its alloys are the metals of choice for the manufacture of dental implants because they are chemically inert and biocompatible. However, for special cohorts of patients, there is still a need for improvements, specifically to increase the ability of implants to integrate into the bone and gum tissues and to prevent bacterial infections that can subsequently lead to peri-implantitis and implant failures. Therefore, titanium implants require sophisticated approaches to improve their postoperative healing and long-term stability. Such treatments range from sandblasting to calcium phosphate coating, fluoride application, ultraviolet irradiation, and anodization to increase the bioactivity of the surface. Plasma electrolytic oxidation (PEO) has gained popularity as a method for modifying metal surfaces and delivering the desired mechanical and chemical properties. The outcome of PEO treatment depends on the electrochemical parameters and composition of the bath electrolyte. In this study, we investigated how complexing agents affect the PEO surfaces and found that nitrilotriacetic acid (NTA) can be used to develop efficient PEO protocols. The PEO surfaces generated with NTA in combination with sources of calcium and phosphorus were shown to increase the corrosion resistance of the titanium substrate. They also support cell proliferation and reduce bacterial colonization and, hence, lead to a reduction in failed implants and repeated surgeries. Moreover, NTA is an ecologically favorable chelating agent. These features are necessary for the biomedical industry to be able to contribute to the sustainability of the public healthcare system. Therefore, NTA is proposed to be used as a component of the PEO bath electrolyte to obtain bioactive surface layers with properties desired for next-generation dental implants.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nitrilotriacetic Acid Improves Plasma Electrolytic Oxidation of Titanium for Biomedical Applications

Kyrylenko

Sowa

Kazek-Kęsik

et al. 2023

ACS Appl. Mater. Interfaces

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“…Bone fractures, especially in the spine and long bones, have a significant impact on patient well-being and are associated with high mortality rates. − Challenges in treatment include instability, low drug effectiveness due to poor bioavailability and short half-lives, and side effects . Emerging solutions include innovative therapeutic agents, technologies like 3D printing and bone scaffolding, , finite element software for surgeries, methods to enhance bone density, , targeted drug delivery, and combined treatments …”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite Incorporated with Fe₃O₄@MCM-41 Core–Shell: A Promising Nanocomposite for Teriparatide Delivery in Bone Tissue Regeneration

Hosseini,

Abdouss,

Golshekan

2023

ACS Omega

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This article presents a comprehensive study of the development of a novel nanocomposite comprising core−shell Fe 3 O 4 @MCM-41 with superparamagnetic properties and hydroxyapatite (HAp). The nanocomposite serves as a pH-responsive nanocarrier, offering an efficient injectable dosage for teriparatide (PTH (1−34)) delivery. The aim is to address the limitations associated with druginduced side effects, precautionary measures, and frequent injections. The nanocomposites, as prepared, were characterized using techniques including X-ray diffraction, Fourier transform infrared, zeta potential, dynamic light scattering, VSM, scanning electron microscopy, and transmission electron microscopy. The nanocomposites' average crystallite diameter was determined to be 27 ± 5 nm. The hydrodynamic size of the PTH (1−34)-loaded nanocarrier ranged from 357 to 495 nm, with a surface charge of −33 mV. The entrapment and loading efficiencies were determined to be 73% and 31%, respectively. All of these findings collectively affirm successful fabrication. Additionally, in vivo medication delivery was investigated using the HPLC method, mirroring the in vitro tests. Utilizing the dialysis approach, we demonstrated sustained-release behavior. PTH (1−34) diffusion increased as the pH decreased from 7.4 to 5.6. After 24 h, drug release was higher at acidic pH (88%) compared to normal pH (43%). The biocompatibility of the PTH (1−34)-loaded nanocarrier was assessed using the MTT assay employing the NIH3T3 and HEK-293 cell lines. The results demonstrated that the nanocarrier not only exhibited nontoxicity but also promoted cell proliferation and differentiation. In the in vivo test, the drug concentration reached 505 μg within 30 min of exposure to the magnetic field. Based on these findings, the Fe 3 O 4 @MCM-41/HAp/PTH (1−34) nanocomposite, in combination with a magnetic field, offers an efficient and biocompatible approach to enhance the therapeutic effect of osteogenesis and overcome drug limitations.

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“…Many bene cial therapeutic agents and innovative technologies for bone fractures are available to treat bone fractures and bone disorders such as osteoporosis. Studies in this eld are growing in the world, including the use of 3D printers and the construction of bone scaffolding [5], the use of nite element method software in surgeries [6], and methods for improved bone tissue density in fractures [7,8], different drug delivery techniques expressly transport medications to bone fractures, as well as improvements in all of these delivery systems when used in combination treatment [9]. However, because bones are dispersed throughout the body [10], the blood concentration of systemic therapeutic agents must be at the limit where it can exert pharmacological activity at the peripheral location.…”

Section: Introductionmentioning

confidence: 99%

Fe 3 O 4 @MCM-41-Hydroxyapatite-Teriparatide nanocomposite: as a highly efficient drug delivery system for bone tissue

Hosseini

Abdouss

Golshekan

2022

Preprint

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Objectives: A novel nanocomposite for targeted delivery of Teriparatide as an efficient inject dosage to improve drug-induced side effects, precautionary limitations, and frequent injection challenges. Methods: Core-shell structure (Fe3O4@MCM-41) by the co-precipitation process and loading of Hydroxyapatite-Teriparatide on its surface were synthesized successfully. The HPLC analysis at in-vitro and in-vivo tests with and without an external magnetic field and MTT assay were performed. Results: MNPs had a roughly 10 nm-sized particle and a spherical-like shape. The hydrodynamic size range was 360–440 nm, and the zeta potential ranged from -15–70 mV. The drug concentration reached 505 μg within 30 minutes of exposure to the magnetic field, and the coexistence of Teriparatide, HAP, and, Fe3O4-MNPs increased the proliferation of bone tissue stem cells. Conclusion: Efficient biocompatible nanocomposite (Fe3O4@MCM-41/HAP-Terip) and magnetic field can improve the therapeutic effect of osteogenesis, and rebate drug limitations.

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Miniplates coated by plasma electrolytic oxidation improve bone healing of simulated femoral fractures on low bone mineral density rats

Cited by 10 publications

References 42 publications

Nitrilotriacetic Acid Improves Plasma Electrolytic Oxidation of Titanium for Biomedical Applications

Nitrilotriacetic Acid Improves Plasma Electrolytic Oxidation of Titanium for Biomedical Applications

Hydroxyapatite Incorporated with Fe₃O₄@MCM-41 Core–Shell: A Promising Nanocomposite for Teriparatide Delivery in Bone Tissue Regeneration

Fe 3 O 4 @MCM-41-Hydroxyapatite-Teriparatide nanocomposite: as a highly efficient drug delivery system for bone tissue

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Miniplates coated by plasma electrolytic oxidation improve bone healing of simulated femoral fractures on low bone mineral density rats

Cited by 10 publications

References 42 publications

Nitrilotriacetic Acid Improves Plasma Electrolytic Oxidation of Titanium for Biomedical Applications

Nitrilotriacetic Acid Improves Plasma Electrolytic Oxidation of Titanium for Biomedical Applications

Hydroxyapatite Incorporated with Fe3O4@MCM-41 Core–Shell: A Promising Nanocomposite for Teriparatide Delivery in Bone Tissue Regeneration

Fe 3 O 4 @MCM-41-Hydroxyapatite-Teriparatide nanocomposite: as a highly efficient drug delivery system for bone tissue

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Product

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Hydroxyapatite Incorporated with Fe₃O₄@MCM-41 Core–Shell: A Promising Nanocomposite for Teriparatide Delivery in Bone Tissue Regeneration