Minipigs: Applications in Toxicology

Brown, L. D.; Stricker‐Kongrad, Alain; Bouchard, Guy

doi:10.1002/0471140856.tx0111s56

Cited by 4 publications

(4 citation statements)

References 47 publications

(61 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Swine have been used extensively in dermal research because of the comparability of their integument to that of humans. During the past half century, they have been used in preclinical dermal toxicology, dermal pharmacokinetics, dermal phototoxicity, dermal wound healing studies, and a broad array of other biomedical research applications (Brown, Stricker-Krongrad, and Bouchard 2013;Gad, Stricker-Krongrad, and Skaanild 2015). Reviews of the use of swine in such studies have been previously published (Fujii et al 1997;Gad, Stricker-Krongrad, and Skaanild 2015;Monteiro-Riviere and Riviere 1996;M.…”

Section: Dermal Modelsmentioning

confidence: 99%

“…Using these miniature breeds allows investigators to conduct experiments in mature (rather than pediatric) animals with a consistent size and health status. Each breed may be utilized in some aspect of dermal toxicology (Brown, Stricker-Krongrad, and Bouchard 2013;Gad, Stricker-Krongrad, and Skaanild 2015;Svendsen 2006; M. M. Swindle et al 2012). The value of miniature swine dermal models for preclinical safety is confirmed by Ganderup (2012) who reviewed miniature swine safety and efficacy data on 43 marketed drugs with previously reported adverse responses.…”

Section: Dermal Modelsmentioning

confidence: 99%

See 1 more Smart Citation

The Miniature Swine as a Model in Experimental and Translational Medicine

2016

Self Cite

View full text Add to dashboard Cite

The use of the miniature swine as a nonrodent species in research has continued to expand for over a decade, and they are becoming routinely used both in experimental pharmacology and as a therapeutic model for human diseases. Miniature swine models are regularly used for studies designed to assess efficacy and safety of new therapeutic compounds given through different routes of exposure and are used as an alternative model to rodents, canines, or nonhuman primates. Translational preclinical swine study data presented here support the current understanding that miniature swine are the animal model of choice for the assessment of drugs targeting endocrine, dermal, and ocular disorders. Because research investigators need to be familiar with some of the important features of the models developed in the miniature swine in order to place clinical and experimental findings in their proper perspective, relevant references and data from these models will be presented, compared, and partially illustrated.

show abstract

Section: Dermal Modelsmentioning

confidence: 99%

Section: Dermal Modelsmentioning

confidence: 99%

The Miniature Swine as a Model in Experimental and Translational Medicine

2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…Miniature swine size, anatomy, physiology, metabolism, and genetics correlate well with human factors. They are also becoming even more attractive as a nonrodent species for general toxicity studies as a result of the increase in expense in the use of dogs and the perceived lay opposition to the use of dogs in research (Brown et al 2013). They have been extensively used for physiological research, primarily cardiovascular, renal, and digestive (Gad et al 2015;Khan 1984), and surgical research (Swindle et al 1988) for years.…”

Section: Discussionmentioning

confidence: 99%

Miniature Swine Breeds in Toxicology and Drug Safety Assessments

Stricker–Krongrad

Shoemake²,

Pereira³

et al. 2015

Toxicol Pathol

Self Cite

View full text Add to dashboard Cite

The use of miniature swine as a nonrodent species in safety assessment has continued to expand for over a decade, and they are becoming routinely used in toxicology and in pharmacology as well as a model for human diseases. Miniature swine models are regularly used for regulatory toxicity studies designed to assess safety of new therapeutic compounds given through different routes of exposure and are used as an alternative model to the canine or the nonhuman primate. Translational preclinical swine study data presented support the current finding that miniature swine are the animal model of choice for assessment of drug absorption, tolerance, and systemic toxicity following systemic exposures. Because research investigators need to be familiar with important anatomic and histopathologic features of the miniature swine in order to place toxicopathologic findings in their proper perspective, clinical and anatomic pathology data from a large number of Sinclair, Hanford, Yucatan, and Gö ttingen breeds from control groups from a wide variety of studies performed between 2004 and 2014 will be presented, compared, and partially illustrated.

show abstract

“…The use of the pig as a nonrodent model in toxicological studies continues to grow. It has been reported that in 2008, over 500 Center for Drug Evaluation and Research (CDER) reviews using minipigs had been filed within the previous 5 years (Brown, Stricker-Kongrad, and Bouchard 2013). The advent of the increased availability of minipigs, coupled with the knowledge that the physiology of the pig is more similar to humans than is the mouse, has led to an increased utilization of pigs in the biomedical sciences (Freeman et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Pigs in Toxicology

et al. 2016

View full text Add to dashboard Cite

Both a rodent and a nonrodent species are required for evaluation in nonclinical safety studies conducted to support human clinical trials. Historically, dogs and nonhuman primates have been the nonrodent species of choice. Swine, especially the miniature swine or minipigs, are increasingly being used in preclinical safety as an alternate nonrodent species. The pig is an appropriate option for these toxicology studies based on metabolic pathways utilized in xenobiotic biotransformation. Both similarities and differences exist in phase I and phase II biotransformation pathways between humans and pigs. There are numerous breeds of pigs, yet only a few of these breeds are characterized with regard to both xenobiotic-metabolizing enzymes and background pathology findings. Some specific differences in these enzymes based on breed and sex are known. Although swine have been used extensively in biomedical research, there is also a paucity of information in the current literature detailing the incidence of background lesions and differences between commonly used breeds. Here, the xenobiotic-metabolizing enzymes are compared between humans and pigs, and minipig background pathology changes are reviewed with emphasis on breed differences.

show abstract

Minipigs: Applications in Toxicology

Cited by 4 publications

References 47 publications

The Miniature Swine as a Model in Experimental and Translational Medicine

The Miniature Swine as a Model in Experimental and Translational Medicine

Miniature Swine Breeds in Toxicology and Drug Safety Assessments

Pigs in Toxicology

Contact Info

Product

Resources

About