temporal networks are widely used to represent a vast diversity of systems, including in particular social interactions, and the spreading processes unfolding on top of them. The identification of structures playing important roles in such processes remains largely an open question, despite recent progresses in the case of static networks. Here, we consider as candidate structures the recently introduced concept of span-cores: the span-cores decompose a temporal network into subgraphs of controlled duration and increasing connectivity, generalizing the core-decomposition of static graphs. To assess the relevance of such structures, we explore the effectiveness of strategies aimed either at containing or maximizing the impact of a spread, based respectively on removing spancores of high cohesiveness or duration to decrease the epidemic risk, or on seeding the process from such structures. The effectiveness of such strategies is assessed in a variety of empirical data sets and compared to baselines that use only static information on the centrality of nodes and static concepts of coreness, as well as to a baseline based on a temporal centrality measure. our results show that the most stable and cohesive temporal cores play indeed an important role in epidemic processes on temporal networks, and that their nodes are likely to include influential spreaders. A large variety of systems find a convenient representation as networks of interactions between components. Network representations have indeed proved to be useful to understand the structure and dynamics of systems as diverse as transportation infrastructures or social networks, as well as to describe processes occurring on top of them, such as information diffusion, epidemic spread, synchronization, etc 1. A large body of work aims in particular at understanding how the network's features impact the outcome of processes taking place on top of them, with the ambition of devising control and prediction capabilities. For instance, several methods have been put forward to identify the nodes of a network that play a more important role in a spreading process, either because they are "influencers" able to widely spread an information, or because they are "sentinels" with a high probability to be reached by a disease in its early stages and thus can give an early warning, or because their immunization is likely to hinder the spread 2-11. Such a task becomes even more complex when dealing with temporal networks, in which edges between nodes can appear and disappear on different time scales. The recent availability of time-resolved data sets of interactions has pushed network science beyond the static graph representation and has led to the development of the field of temporal networks 12,13. The temporal dimension can yield non-trivial temporal features such as broad distributions of interaction times and of inter-event times ("burstiness"), heterogeneous activity distributions, causality constraints, and overall a broader diversity of activity/connectivity patterns tha...