Mining for novel antibiotics in the age of antimicrobial resistance

Udaondo, Zulema; Matilla, Miguel A.

doi:10.1111/1751-7915.13662

Cited by 25 publications

(33 citation statements)

References 26 publications

(39 reference statements)

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“…Bacterial and viral infections are two of the top causes of deaths worldwide. An increasing number of reports describing the development of bacterial and viral resistance, including in the form of polymicrobial infections, against currently available antibiotics and antivirals has urged the use of alternative products with potential activities against those two types of pathogens [141][142][143][144]. One of the commodities equipped with such activities are bee products [3,[145][146][147][148][149].…”

Section: Bee Products As Prospective Sources Of Antibacterial and Antiviral Agentsmentioning

confidence: 99%

Pharmaceutical Prospects of Bee Products: Special Focus on Anticancer, Antibacterial, Antiviral, and Antiparasitic Properties

et al. 2021

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Bee products have long been used in traditional healing practices to treat many types of disorders, including cancer and microbial-related diseases. Indeed, several chemical compounds found in bee products have been demonstrated to display anticancer, antibacterial, antiviral, and antiparasitic properties. With the improvement of research tools and in view of recent advances related to bee products, this review aims to provide broad yet detailed insight into the pharmaceutical prospects of bee products such as honey, propolis, bee pollen, royal jelly, bee bread, beeswax, and bee venom, in the domain of cancer and infectious disease management. Available literature confirms the efficacy of these bee products in the alleviation of cancer progression, inhibition of bacterial and viral proliferation, and mitigation of parasitic-related symptoms. With such potentials, bioactive components isolated from the bee products can be used as an alternative approach in the long-run effort to improve humans’ health at a personal and community level.

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Section: Bee Products As Prospective Sources Of Antibacterial and Antiviral Agentsmentioning

confidence: 99%

Pharmaceutical Prospects of Bee Products: Special Focus on Anticancer, Antibacterial, Antiviral, and Antiparasitic Properties

et al. 2021

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“…E. coli and Salmonella are among those zoonotic bacteria that can be transmitted to humans by foodborne route [ 20 ] and therefore are able to confer resistance genes to bacteria in humans. Infections caused by resistant bacteria can lead to treatment failure [ 20 ] and are expected to become the major cause of death in humans by 2050 [ 22 ], which highlights public health importance of decreasing antibiotic usage in farm animals.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity of Flavonoids in LPS-Treated IPEC-J2 Porcine Intestinal Epithelial Cells and Their Antibacterial Effect against Bacteria of Swine Origin

et al. 2020

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Beneficial effects of flavonoids are widely known in human medicine, but less information is available about their veterinary usage. Based on their antioxidant and antibacterial activity, proanthocyanidins (PAs) and luteolin (LUT) might be used in the prevention and treatment of gastrointestinal infections in swine. In this study, in vitro beneficial effects of grape seed oligomeric proanthocyanidins (GSOPs) and LUT were investigated against bacterial endotoxin (LPS)-induced oxidative stress in IPEC-J2 porcine epithelial intestinal cells. Furthermore, antibacterial effects of GSOP and LUT were assessed against field isolates of Escherichia coli and Salmonella enterica ser. Typhimurium. Both GSOP and LUT were found to possess potent in vitro antioxidant activity in LPS-treated IPEC-J2 cells; furthermore, they showed a bacteriostatic effect against the tested bacterial strains of porcine origin. Both flavonoids seem to be effective in the protection of porcine intestinal epithelial cells against Gram-negative bacteria in vitro, but further in vivo studies are necessary to confirm these activities and to establish their optimal dosage regimen for future usage in veterinary practice.

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“…Previously, we noted that the combined 1 H and 13 C NMR chemical shift fingerprint obtained from 1 H-{ 13 C} HSQC spectra is sufficiently sensitive to differentiate diastereomers of a particular CLiP even when they differ in only a single D/L configuration (43). More so, it is even sensitive to the stereochemistry of the 3hydroxy moiety of the fatty acid tail as well (44).…”

Section: Introductionmentioning

confidence: 99%

An NMR fingerprint matching approach for the identification and structural re-evaluation ofPseudomonaslipopeptides

Roo

Verleysen

Kovács

et al. 2022

Preprint

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Cyclic lipopeptides (CLiPs) are secondary metabolites secreted by a range of bacterial phyla. CLiPs display diverse structural variations in terms of the number of the amino acid residues, macrocycle size, amino acid identity and stereochemistry (e.g. D- vs. L-amino acids). Reports detailing the discovery of novel or already characterized CLiPs from new sources appear regularly in literature. However, in some cases, the lack of characterization detail threatens to cause considerable confusion, especially if configurational heterogeneity is present for one or more amino acids. The NMR fingerprint matching approach introduced in this work exploits the fact that the 1H and 13C NMR chemical shift fingerprint is sufficiently sensitive to differentiate the diastereomers of a particular CLiP even when they only differ in a single D/L configuration. This provides a means for a fast screening to determine whether an extracted CLiP has been reported before, by simply comparing the fingerprint of a novel CLiP with that of a reference CLiP. Even when the stereochemistry of a particular reference CLiP is unknown, the NMR fingerprint approach still allows to verify whether a CLiP from a novel source is identical to the reference. To facilitate this, we have made a publicly available knowledge base at https://www.rhizoclip.be, where we present an overview of published NMR fingerprint data of characterized CLiPs, together with literature data on the originally determined structures. The latter includes a description of the CLiPs original description, molecular mass, three dimensional structures (if available), and a summary of published antimicrobial activities. Moreover, a detailed protocol will be made available for researchers that wish to record NMR data of their newly extracted lipopeptides to compare them to the publicly available reference data.

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Mining for novel antibiotics in the age of antimicrobial resistance

Cited by 25 publications

References 26 publications

Pharmaceutical Prospects of Bee Products: Special Focus on Anticancer, Antibacterial, Antiviral, and Antiparasitic Properties

Pharmaceutical Prospects of Bee Products: Special Focus on Anticancer, Antibacterial, Antiviral, and Antiparasitic Properties

Antioxidant Activity of Flavonoids in LPS-Treated IPEC-J2 Porcine Intestinal Epithelial Cells and Their Antibacterial Effect against Bacteria of Swine Origin

An NMR fingerprint matching approach for the identification and structural re-evaluation ofPseudomonaslipopeptides

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