Mining Chemodiversity From Biodiversity: Pharmacophylogeny of Ranunculales Medicinal Plants (Except Ranunculaceae)

Hao, Da‐Cheng

doi:10.1016/b978-0-12-814232-5.00003-4

Cited by 2 publications

(1 citation statement)

References 228 publications

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“…These alkaloids from T. sagittata tuber (Radix Tinospora) have antifouling (Li et al, 2016), anti-inflammatory (C. , and α-glucosidase inhibitory activities (Li et al, 2016). Moreover, these alkaloids, flavonoids, lignans, terpenoids, and other compounds provide multiple therapeutic uses of Radix Tinospora in TCM, such as improvement of immune capacity, prevention against upper respiratory infections, and lower oral ulcers, treatment of diabetes, anticancer, and protection of liver from different diseases (Hao, 2019b). In addition to medicinal uses, Tinospora is a major group of Angiosperms (Chi et al, 2016) and T. sagittata is a model plant for studying the evolutionary relationship of species within the family of Menispermaceae.…”

Section: Introductionmentioning

confidence: 99%

Chromosome-scale genome assembly ofTinospora sagittata(Oliv.) Gagnep. enhances identifying genes involved in the biosynthesis of jatrorrhizine

Alami

Shu

Liu

et al. 2023

Preprint

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Tinospora sagittata (Oliv.) Gagnep. is an important medicinal tetraploid plant in the Menispermaceae family. Its tuber, namely "Radix Tinosporae" used in Traditional Chinese Medicine, is rich in medicinal terpenoids and benzylisoquinoline alkaloids (BIAs), To enhance understanding the biosynthesis of medicinal compounds, we, herein, report the assembly of a high quality chromosome-scale genome with both PacBio HiFi and Illumina sequencing technologies. The size of assembled genome was 2.33 Gb consisting of 4070 scaffolds (N50=42.06Mb), of which 92.05% were assigned to 26 pseudochromosomes in A and B sub-genomes. A phylogenetic analysis with the T. sagittata and other 16 plant genomes estimated the evolutionary placement of T. sagittata and its divergence time in Ranunculales. Further genome evolution analysis characterized one round tandem duplication about 1.5 million years ago (MYA) and one whole-genome duplication (WGD) about 86.9 MYA. WGD contributed to the duplication of clade-specific cytochrome P450 gene family in Ranunculales. Moreover, sequencing mining obtained genome-wide genes involved in the biosynthesis of alkaloids and terpenoids. TsA02G014550, one candidate, was functionally characterized to catalyze the formation of (S)-canadine in the jatrorrhizine biosynthetic pathway. Taken together, the assembled genome of T. sagittata provides useful sequences to understand the biosynthesis of jatrorrhizine and other BIAs in plants.

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Section: Introductionmentioning

confidence: 99%

Chromosome-scale genome assembly ofTinospora sagittata(Oliv.) Gagnep. enhances identifying genes involved in the biosynthesis of jatrorrhizine

Alami

Shu

Liu

et al. 2023

Preprint

View full text Add to dashboard Cite

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Chromosome-scale genome assembly of medicinal plant Tinospora sagittata (Oliv.) Gagnep. from the Menispermaceae family

Alami,

Shu,

Liu

et al. 2024

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Tinospora sagittata (Oliv.) Gagnep. is an important medicinal tetraploid plant in the Menispermaceae family. Its tuber, Radix Tinosporae, used in traditional Chinese medicine, is rich in diterpenoids and benzylisoquinoline alkaloids (BIAs). To enhance our understanding of medicinal compounds’ biosynthesis and Menispermaceae’s evolution, we herein report assembling a high-quality chromosome-scale genome with both PacBio HiFi and Illumina sequencing technologies. PacBio Sequel II generated 2.5 million circular consensus sequencing (CCS) reads, and a hybrid assembly strategy with Illumina sequencing resulted in 4483 contigs. The assembled genome size was 2.33 Gb, consisting of 4070 scaffolds (N50 = 42.06 Mb), of which 92.05% were assigned to 26 pseudochromosomes. T. sagittata’s chromosomal-scale genome assembly, the first species in Menispermaceae, aids Menispermaceae evolution and T. sagittata’s secondary metabolites biosynthesis understanding.

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Mining Chemodiversity From Biodiversity: Pharmacophylogeny of Ranunculales Medicinal Plants (Except Ranunculaceae)

Cited by 2 publications

References 228 publications

Chromosome-scale genome assembly ofTinospora sagittata(Oliv.) Gagnep. enhances identifying genes involved in the biosynthesis of jatrorrhizine

Chromosome-scale genome assembly ofTinospora sagittata(Oliv.) Gagnep. enhances identifying genes involved in the biosynthesis of jatrorrhizine

Chromosome-scale genome assembly of medicinal plant Tinospora sagittata (Oliv.) Gagnep. from the Menispermaceae family

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