Minimum Standardized Uptake Value from Quantitative Bone Single-Photon Emission Computed Tomography/Computed Tomography for Evaluation of Femoral Head Viability in Patients with Femoral Neck Fracture

Ryoo, Hyun Gee; Lee, Won Woo; Kim, Ji Young; Kong, Eun Jung; Choi, Woo Hee; Yoon, Joon-Kee

doi:10.1007/s13139-019-00600-2

Cited by 9 publications

(8 citation statements)

References 20 publications

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“…First, it is an accurate quantitative tool for evaluating salivary gland function. The statement is based on the recent progress in quantitative SPECT/CT technique 22 , which has been proven in a variety of clinical applications 13 – 21 . Notably, the current SPECT/CT protocol produced normal %ID (0.36 ± 0.02% for the parotid and 0.17 ± 0.01% for the submandibular) and %EF (61.41 ± 1.38% for the parotid and 45.22 ± 2.46% for submandibular) 12 reference ranges, which are comparable to the results obtained from conventional planar imaging 36 , 37 .…”

Section: Discussionmentioning

confidence: 99%

“…Quantitative single-photon emission computed tomography/computed tomography (SPECT/CT) is a promising method for the functional evaluation of organs 12 . Recent technological development has allowed the application of quantitative nuclear imaging parameters, such as %injected dose (%ID) and standardized uptake value (SUV), to SPECT/CT imaging 13 – 21 . Quantitative salivary gland SPECT/CT holds promise as a new imaging modality 12 , 22 since the interpretation of the salivary gland scintigraphy depends on the quantitation of the uptake (i.e., %ID) of Tc-99m pertechnetate by the salivary glands.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative salivary gland SPECT/CT using deep convolutional neural networks

Park

Lee

et al. 2021

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Quantitative single-photon emission computed tomography/computed tomography (SPECT/CT) using Tc-99m pertechnetate aids in evaluating salivary gland function. However, gland segmentation and quantitation of gland uptake is challenging. We develop a salivary gland SPECT/CT with automated segmentation using a deep convolutional neural network (CNN). The protocol comprises SPECT/CT at 20 min, sialagogue stimulation, and SPECT at 40 min post-injection of Tc-99m pertechnetate (555 MBq). The 40-min SPECT was reconstructed using the 20-min CT after misregistration correction. Manual salivary gland segmentation for %injected dose (%ID) by human experts proved highly reproducible, but took 15 min per scan. An automatic salivary segmentation method was developed using a modified 3D U-Net for end-to-end learning from the human experts (n = 333). The automatic segmentation performed comparably with human experts in voxel-wise comparison (mean Dice similarity coefficient of 0.81 for parotid and 0.79 for submandibular, respectively) and gland %ID correlation (R2 = 0.93 parotid, R2 = 0.95 submandibular) with an operating time less than 1 min. The algorithm generated results that were comparable to the reference data. In conclusion, with the aid of a CNN, we developed a quantitative salivary gland SPECT/CT protocol feasible for clinical applications. The method saves analysis time and manual effort while reducing patients’ radiation exposure.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quantitative salivary gland SPECT/CT using deep convolutional neural networks

Park

Lee

et al. 2021

Sci Rep

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“…We reviewed 13 original articles that focused on SPECT/CT for spinal imaging [7][8][9][10][11][12][13][14][15][16][17][18][19], eight that focused on SPECT/CT of the foot and/or ankle imaging [19][20][21][22][23][24][25][26], ten that focused on SPECT/CT at the knee imaging [19][20][21][27][28][29][30][31][32][33][34], six that focused on SPECT/CT for hip imaging [19,[35][36][37][38][39], and four A slice thickness of 0.33-2 mm was commonly used. These CT protocols are summarized in Table 3.…”

Section: Literature Search Of Bone Spect/ct Used Over the Past 3 Yearsmentioning

confidence: 99%

Computed Tomography (CT) Protocols Associated with Cardiac and Bone Single-Photon Emission Computed Tomography/CT (SPECT/CT) in Korea

Lee

Kim

Park

et al. 2020

Nucl Med Mol Imaging

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Purpose Single-photon emission computed tomography/computed tomography (SPECT/CT) is an advanced hybrid nuclear medicine technology that generates both functional and anatomical images in a single study. As utilization of SPECT/CT in Korea has been increasing, the purpose of this study was to survey its application of cardiac and skeletal SPECT/CT imaging for protocol optimization. Methods We surveyed CT protocols established for cardiac and skeletal SPECT/CT. We searched the guidelines for the CT protocols for SPECT/CT and reviewed the literature recently published. Results Among 36 hybrid SPECT scanners equipped with four or more multi-channel detector CTs (MDCTs), 18 scanners were used to perform cardiac studies at both very low current CT (30-80 mA; 11.1%) and ultra-low current CT (13-30 mA; 88.9%). Among the 33 canners, very low current (≤ 80 mA) CT or low current CT (80-130 mA) was used in 23.5%, and 41.8% for spine disorders, and in 36.4% or 30.3% for foot/ankle disorders, respectively. In the CT reconstructions, slice thickness of 5 mm for cardiac studies was most commonly used (94.4%); thinner slices (0.6-1.0 mm) for spine and foot/ankle studies were used in 24.2% and 45.5%, respectively. We also reviewed the international guidelines. Conclusions The results and current recommendations will be helpful for optimizing CT protocols for SPECT/CT. Optimization of SPECT/CT protocols will be required for generating the proper strategy for the specific lesions and clinical purpose.Keywords SPECT/CT . CT protocols . Optimization Eun Jeong Lee and Ji Young Kim contributed equally to this work.

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“…Several studies have investigated the utility of bone SPECT/CT for the evaluation of femoral head viability in adult patients with femoral neck fractures [ 14 15 16 17 18 19 ]. However, no study has yet evaluated the usefulness of bone SPECT/CT in predicting the risk of AVN in children.…”

Section: Introductionmentioning

confidence: 99%

Usefulness of Bone SPECT/CT for Predicting Avascular Necrosis of the Femoral Head in Children with Slipped Capital Femoral Epiphysis or Femoral Neck Fracture

et al. 2022

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Objective This study aimed to investigate the usefulness of bone single-positron emission tomography/computed tomography (SPECT/CT) of the hip in predicting the later occurrence of avascular necrosis (AVN) after slipped capital femoral epiphysis (SCFE) or femoral neck fracture in pediatric patients. The quantitative parameters of SPECT/CT useful in predicting AVN were identified. Materials and Methods Twenty-one (male:female, 10:11) consecutive patients aged < 18 years (mean age ± standard deviation [SD], 11.0 ± 2.7 years) who underwent surgery for SCFE or femoral neck fracture and postoperative bone SPECT/CT were included. The maximum standardized uptake value (SUV), mean SUV, and minimum SUV of the femoral head were measured. The ratios of the maximum SUV, mean SUV, and minimum SUV of the affected femoral head to the contralateral side were determined. Patients were followed up for > 1 year after the surgery. The SPECT/CT parameters were compared between patients who developed AVN and those who did not. The accuracy of SPECT/CT parameters for predicting AVN was assessed. Results Six patients developed AVN. There was a significant difference in the ratio of the mean SUV among patients who developed AVN (mean ± SD, 0.8 ± 0.3) and those who did not (1.1 ± 0.2, p = 0.018). However, there were no significant differences in the ratios of the maximum and minimum SUV between the groups (all p = 0.205). For the maximum, mean, and minimum SUVs, no significant differences were observed between the groups ( p = 0.519, 0.733, and 0.470, respectively). The cutoff mean SUV ratio of 0.87 yielded a 66.7% sensitivity and 93.2% specificity for predicting AVN. Conclusion Quantitative bone SPECT/CT is useful for evaluating femoral head viability in pediatric patients with SCFE or femoral neck fractures. Clinicians should consider the high possibility of later AVN development in patients with a decreased mean SUV ratio.

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Minimum Standardized Uptake Value from Quantitative Bone Single-Photon Emission Computed Tomography/Computed Tomography for Evaluation of Femoral Head Viability in Patients with Femoral Neck Fracture

Cited by 9 publications

References 20 publications

Quantitative salivary gland SPECT/CT using deep convolutional neural networks

Quantitative salivary gland SPECT/CT using deep convolutional neural networks

Computed Tomography (CT) Protocols Associated with Cardiac and Bone Single-Photon Emission Computed Tomography/CT (SPECT/CT) in Korea

Usefulness of Bone SPECT/CT for Predicting Avascular Necrosis of the Femoral Head in Children with Slipped Capital Femoral Epiphysis or Femoral Neck Fracture

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