Minimum infusion rate of alfaxalone for total intravenous anaesthesia after sedation with acepromazine or medetomidine in cats undergoing ovariohysterectomy

Schwarz, Andrea; Kalchofner, Karin; Palm, Julia; Picek, Stephanie; Hartnack, Sonja; Bettschart‐Wolfensberger, Regula

doi:10.1111/vaa.12144

Cited by 27 publications

(23 citation statements)

References 25 publications

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“…In a study by Schwarz et al. () premedication had a significant influence on arterial pressure using alfaxalone CRI for maintenance in healthy cats. Hypotension occurred in more than 50% of the cats premedicated with acepromazine, but in <10% after 20 μg kg −1 of medetomidine IM.…”

Section: Discussionmentioning

confidence: 99%

“…; Schwarz et al. ). The propofol induction dose is based on one study comparing propofol and alfaxalone induction in cats (Martinez Taboada & Murison ).…”

Section: Discussionmentioning

confidence: 99%

“…The difference of estimated mean values between the groups was based on preliminary (Schwarz et al. ) and internal clinical audit data (occurrence of apnoea group A = 20%; group P = 80%). It was anticipated that a significant difference of 0.05 (α error) between treatments could be detected in two groups of ten cats.…”

Section: Methodsmentioning

confidence: 99%

“…) cats did not exhibit apnoea or a decrease in arterial haemoglobin oxygen saturation (SpO 2 ) < 90% during induction and maintenance of anaesthesia using alfaxalone (Schwarz et al. ).…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the effects of propofol or alfaxalone for anaesthesia induction and maintenance on respiration in cats

Campagna

Schwarz

Keller

et al. 2015

Veterinary Anaesthesia and Analgesia

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Section: Discussionmentioning

confidence: 99%

“…; Schwarz et al. ). The propofol induction dose is based on one study comparing propofol and alfaxalone induction in cats (Martinez Taboada & Murison ).…”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…) cats did not exhibit apnoea or a decrease in arterial haemoglobin oxygen saturation (SpO 2 ) < 90% during induction and maintenance of anaesthesia using alfaxalone (Schwarz et al. ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of the effects of propofol or alfaxalone for anaesthesia induction and maintenance on respiration in cats

Campagna

Schwarz

Keller

et al. 2015

Veterinary Anaesthesia and Analgesia

Self Cite

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show abstract

“…Características essas apresentadas pela afaxalona e que permitem que seja usada em infusão contínua por períodos maiores. Dessa maneira, esse fármaco tem ganhado público para manutenção anestésica, por ser avaliada como efetiva para tal (HERBERT et al, 2013;SCHWARZ et al, 2014).…”

Section: Anestesia Total Intravenosa Com Alfaxalonaunclassified

O Uso De Alfaxalona Em Pequenos Animais

Santos¹,

Fontanela²,

Taffarel³

2018

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RESUMOA alfaxalona é um esteroide neuroativo sintético capaz de induzir a anestesia por meio da ativação de receptores de ácido gama-aminobutírico. Tem como efeito adverso mínimo depressão respiratória e cardiovascular. A alfaxalona também não promove crescimento bacteriano. Essa revisão teve por objetivo relatar o uso clínico de alfaxalona em pequenos animais (cães e gatos), através da sua farmacocinética, farmacodinâmica, doses e vias de administração, uso na indução, analgesia promovida, utilização em infusão contínua, como ocorre a recuperação e o uso em cesárias, promovendo o conhecimento sobre esse fármaco e seus benefícios para os veterinários brasileiros. Em conclusão a utilização de alfaxalona na rotina anestésica de pequenos animais possui diversas vantagens, desde que sejam atentados os efeitos adversos para cada individualidade do paciente e ocorra a implantação de um protocolo correto. PALAVRAS-CHAVE: anestesia, cão, gato. THE USE OF ALFAXALONE IN SMALL ANIMALS ABSTRACTAlfaxalone is a synthetic neuroactive steroid capable of inducing anesthesia through the activation of gamma-aminobutyric acid receptors. It has as adverse effect only a minimal respiratory depression, presenting mainly apnea. However, it promotes minimal cardiovascular depression soon after induction. Alfaxalone also does not promote bacterial growth. This review aimed to report the clinical use of alfaxalone in small animals (dogs and cats), through its pharmacokinetics, pharmacodynamics, doses and routes of administration, use in induction, promoted analgesia, use in continuous infusion, recovery and use in cesareans. Aiming to promote knowledge about this drug and its benefits for Brazilian veterinarians. In conclusion, the use of alfaxalone in the anesthetic routine of small animals has several advantages, as long as the adverse effects for each individuality of the patient are observed and the implementation of a correct protocol occurs.

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Injectable Anesthetics and Induction of Anesthesia

Steagall

2017

Feline Anesthesia and Pain Management

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Minimum infusion rate of alfaxalone for total intravenous anaesthesia after sedation with acepromazine or medetomidine in cats undergoing ovariohysterectomy

Cited by 27 publications

References 25 publications

Comparison of the effects of propofol or alfaxalone for anaesthesia induction and maintenance on respiration in cats

Comparison of the effects of propofol or alfaxalone for anaesthesia induction and maintenance on respiration in cats

O Uso De Alfaxalona Em Pequenos Animais

Injectable Anesthetics and Induction of Anesthesia

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