Minimum Alveolar Concentrations of Methoxyflurane, Halothane, Ether and Cyclopropane in Man

Saidman, Lawrence J.; Eger, Edmond I.; Munson, Edwin S.; Babad, Arthur A.; Muallem, Musa

doi:10.1097/00000542-196711000-00009

Cited by 155 publications

(39 citation statements)

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“…For a system undergoing an all-or-none transition ACp = l -n(AH)2 ACP=(lK)2* IT2 [1] in which K = equilibrium constant for the transition, n = the number of residues in the macromolecular system, AH = the enthalpy change per residue, and R = universal gas constant. At the melting temperature, Tm, K = 1 and…”

Section: Methodsmentioning

confidence: 99%

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Effect of anesthetics and pressure on the thermotropic behavior of multilamellar dipalmitoylphosphatidylcholine liposomes.

Mountcastle¹,

Biltonen²,

Halsey³

1978

Proc. Natl. Acad. Sci. U.S.A.

139

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The effects of gaseous anesthetics and pressure on the thermotropic behavior of multilamellar dipalmitoylphosphatidylcholine liposomes were studied by using a highsensitivity differential scanning calorimeter. It was found that halothane and enflurane decreased the transition temperature and increased the width of the transition without affecting the enthalpy change for the main gel-to-liquid crystalline transition. This emonstrated that the anesthetics decreased the degree of cooperative interaction between phospholipid molecules within the bilayer. Increasing the pressure increased the transition temperature but did not affect the transition width or enthalpy change. However, the increase in pressure reversed the effect of anesthetic on both the transition temperature and transition width. It is sugested that an understanding of the effect of anesthetics on the degree of cooperative interaction between phospholipids may be a key to understanding anesthetic action.The physiological effect of inhalation anesthetics is likely a manifestation of the perturbation of membrane functions associated with synaptic transmission of nerve impulses. This conclusion is primarily based on the high degree of correlation between anesthetic potency and lipid solubility (1, 2). Although it is possible that the primary sites of the action of anesthetics are specific membrane proteins, an attractive alternative is that such action is the result of induced changes in the dynamic structure of the lipid matrix.Trudell and coworkers (3) have demonstrated that general anesthetics decrease the gel-to-liquid crystalline phase transition temperature of phospholipid bilayers and that this effect can be reversed by application of moderate pressures [-100 atmospheres (atm) (10 MPa)] to the system. This result is particularly intriguing because the physiological effect can also be reversed by moderate pressures (4). Recently, Trudell (5) developed a phenomenological theory of anesthesia based on the concept of lateral phase separation in the membrane. This theory focuses on the absolute increase in fluidity of the phospholipid matrix caused by anesthetics. It was suggested that, when phase separation no longer exists, membranes are less able to facilitate the protein conformational changes necessary for normal physiological function.In order to assess carefully the effect of the gaseous anesthetics on the thermotropic behavior of lipid bilayers, a detailed study was initiated using a highly sensitive differential scanning calorimeter. In addition, the influence of pressure on this behavior was ascertained by using a pressure cell adapted for this calorimeter. The results of this study show that the general anesthetics halothane (CF3CHBrCl) and enflurane (CHF2OCF2CHFCI) decrease the transition temperature without affecting the enthalpy change for the transition but that the degree of cooperative interaction between phospholipid molecules is decreased. Both these effects can be reversed by the application of moderate pressures. We there...

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Section: Methodsmentioning

confidence: 99%

“…This conclusion is primarily based on the high degree of correlation between anesthetic potency and lipid solubility (1,2). Although it is possible that the primary sites of the action of anesthetics are specific membrane proteins, an attractive alternative is that such action is the result of induced changes in the dynamic structure of the lipid matrix.…”

mentioning

confidence: 99%

Effect of anesthetics and pressure on the thermotropic behavior of multilamellar dipalmitoylphosphatidylcholine liposomes.

Mountcastle¹,

Biltonen²,

Halsey³

1978

Proc. Natl. Acad. Sci. U.S.A.

139

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“…Halothane ED50 in the bw; st; svn strain is close to that of Mammalia: e.g. humans (0.77%, Saidman et al 1967), dogs (0.87%, Eger et al 1965), mice and monkeys (0.86% and 1.0%, respectively, Raventos 1956). The ED50 value in the Eth-29 strain is the highest among them described above.…”

mentioning

confidence: 58%

Median effective doses (ED50) of halothane and chloroform in sensitive and resistant strains of Drosophila melanogaster.

Gamo

Nakashima-Tanaka

Ogaki

1980

The Japanese journal of genetics

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Ether resistant strain (Eth-29) and one of the sensitive strains (bw; st; svn) which were assessed by mortalities, were used to determine median effective doses (EDbo) of halothane and chloroform. It was demonstrated that the Eth-29 strain was resistant and the bw; st; svn strain was sensitive to both of halothane and chloroform anesthesia. Reciprocal crosses between the two strains suggested that the resistance to halothane anesthesia was a sex-linked recessive trait and that the resistance to chloroform anesthesia was an autosomal incompletely dominant or a polygenic trait. Maternal effects may not be negligible in both of the resistant traits.Ether resistant (Eth) strain was developed from one female fly which was hard to be anesthetized by ether. On the other hand, more than a hundred stock strains were tested for their ether sensitivity and more sensitive strains to ether were used as the ether sensitive strains. We have carried out genetic studies of the resistance to volatile anesthetics by using those resistant and sensitive strains. It was revealed that the Eth strain was resistant and that the bw; st; svn strain was sensitive to ether (Ogaki et al. 1967), chloroform (Gamo et al. 1979) and halothane (Gamo et al. in preparation). Thus, the Eth strain shows a cross-resistance to ether, chrolof orm and halothane at strain level. However, the resistances to the three anesthetic agents may be controlled by different genes, because the locus of major gene(s) to the ether resistance is on mapunit 61± of the third chromosome and the minor genes are on the first (X) and fourth chromosomes (Ogaki et al. 1967), and the major gene(s) to the chloroform resistance is located on the X chromosome and the minor gene(s) is on the second chromosome (Gamo et al. 1979), although both of the ether and chloroform resistances are completely 1) The work was cation, Japan.supported in part by a Grant-in-Aid (No. 440009) from the Ministry of Edu-

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“…Considerando que la potencia anestésica del éter es muy similar a la del sevoflurano, pues ambos presentan un valor de CAM aproximada de 2 (1,35), es factible suponer que es mínimo el riesgo de aparición de efectos sistémicos en el contexto concreto de la aplicación de sevoflurano sobre heridas complicadas en dosis inferiores a 50 ml.…”

Section: Efectos Sistémicos Para El Pacienteunclassified

Eficacia analgésica del sevoflurano tópico en heridas

Pardo

Sáenz

2017

Rev. Soc. Esp. Dolor.

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Instrucciones de citación para el artículo / Citation instructions for the article:Gerónimo Pardo Manuel, Cortiñas Sáenz Manuel. Eficacia analgésica del sevoflurano tópico en heridas / Analgesic efficacy of topical sevoflurane on wounds. Rev. Soc. Esp. Dolor. 2017Dolor. . doi: 10.20986/resed.2017Dolor. .3617/2017 Este es un archivo PDF de un manuscrito inédito que ha sido aceptado para su publicación en la Revista de la Sociedad Española del Dolor. Como un servicio a nuestros clientes estamos proporcionando esta primera versión del manuscrito en estado de prepublicación. El manuscrito será sometido a la corrección de estilo final, composición y revisión de la prueba resultante antes de que se publique en su forma final. Tenga en cuenta que durante el proceso de producción se pueden dar errores lo que podría afectar el contenido final. El copyright y todos los derechos legales que se aplican al artículo pertenecen a la Revista de la Sociedad Española de Dolor.

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Minimum Alveolar Concentrations of Methoxyflurane, Halothane, Ether and Cyclopropane in Man

Cited by 155 publications

References 0 publications

Effect of anesthetics and pressure on the thermotropic behavior of multilamellar dipalmitoylphosphatidylcholine liposomes.

Effect of anesthetics and pressure on the thermotropic behavior of multilamellar dipalmitoylphosphatidylcholine liposomes.

Median effective doses (ED50) of halothane and chloroform in sensitive and resistant strains of Drosophila melanogaster.

Eficacia analgésica del sevoflurano tópico en heridas

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