2018
DOI: 10.1016/j.trci.2018.06.005
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Minimotifs dysfunction is pervasive in neurodegenerative disorders

Abstract: Minimotifs are modular contiguous peptide sequences in proteins that are important for posttranslational modifications, binding to other molecules, and trafficking to specific subcellular compartments. Some molecular functions of proteins in cellular pathways can be predicted from minimotif consensus sequences identified through experimentation. While a role for minimotifs in regulating signal transduction and gene regulation during disease pathogenesis (such as infectious diseases and cancer) is established, … Show more

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