Minimizing the risk of early symptomatic parastomal herniation

Abstract

This letter reports results of a systematic review with meta-analysis which did not include research directly involving human or animal participation.

Statin therapy and postoperative outcomes after major colorectal surgery: The available evidence is not conclusive and robust evidence synthesis may be challenging!

“…In fact, statins are thought to have anti-inflammatory effects by directly attenuating the proinflammatory cytokines including interleukin 6, interleukin 8 and tumour necrosis factor α which are released in response to surgical trauma and are inversely correlated with recovery after surgery [2,3]. There are currently six comparative studies [1,[4][5][6][7][8] (including the study by Pourlotfi et al) on the outcomes of statin vs. no statin in patients undergoing major colorectal surgery. These are one randomized controlled trial [8] and five retrospective cohort studies [1,[4][5][6][7] and include 42 114 patients (11 411 in the statin group and 30 703 in the non-statin group).…”

“…There are currently six comparative studies [1,[4][5][6][7][8] (including the study by Pourlotfi et al) on the outcomes of statin vs. no statin in patients undergoing major colorectal surgery. These are one randomized controlled trial [8] and five retrospective cohort studies [1,[4][5][6][7] and include 42 114 patients (11 411 in the statin group and 30 703 in the non-statin group). There are more patients in the statin group classed as American Society of Anesthesiologists (ASA) Grade III (risk difference [RD] 0.04, 95% CI 0.01-0.06, P = 0.01) and ASA Grade IV (RD 0.01, 95% CI 0.00-0.01, P < 0.0001) compared with the non-statin group.…”