Minimally invasive therapeutic ultrasound: Ultrasound-guided ultrasound ablation in neuro-oncology

Belzberg, Micah; Mahapatra, Smruti; Perdomo‐Pantoja, Alexander; Chavez, Francisco; Morrison, K.; Xiong, Kah Timothy; Gamo, Nao J.; Restaino, Stephen M.; Thakor, Nitish V.; Yazdi, Youseph; Iyer, Rajiv R.; Tyler, Betty; Theodore, Nicholas; Luciano, Mark; Brem, Henry; Groves, Mari L.; Cohen, Alan R.; Manbachi, Amir

doi:10.1016/j.ultras.2020.106210

Cited by 17 publications

(6 citation statements)

References 18 publications

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“…11 To date, the BrainPath tubular retraction system has previously been used to surgically access deep intraparenchymal lesions including spontaneous intracranial hemorrhage, tumor, cavernous malformations, radiation necrosis, and colloid cysts. 4,5,[12][13][14][15][16][17][18][19] Its use in the microsurgical resection of AVMs has only been sparsely reported in the literature. Labib et al reported its first use in the successful resection of 2 AVMs.…”

Section: Discussionmentioning

confidence: 99%

Surgical Resection of Deep-Seated Arteriovenous Malformations Through Stereotactically Guided Tubular Retractor Systems: A Case Series

Achey

Kashkoush

Potter

et al. 2023

Operative Neurosurgery

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BACKGROUND: Arteriovenous malformations (AVMs) in the subcortical and/or periventricular regions can cause significant intraventricular and intracranial hemorrhage. These AVMs can pose a unique surgical challenge because traditional, open approaches to the periventricular region require significant cortical/white matter retraction to establish sufficient operative corridors, which may result in risk of neurological injury. Minimally invasive tubular retractor systems represent a novel, feasible surgical option for treating deep-seated AVMs. OBJECTIVE: To explore 5 cases of NICO BrainPath-assisted resection of subcortical/ periventricular AVMs. METHODS: Five patients from a single institution were operated on for deep-seated AVMs using tubular retractor systems. Collected data included demographics, AVM specifications, preoperative neurological status, postoperative neurological status, and postoperative/intraoperative angiogram results. RESULTS: Five patients, ranging from age 10 to 45 years, underwent mini-craniotomy for stereotactically guided tubular retractor-assisted AVM resection using neuronavigation for selecting a safe operative corridor. No preoperative embolization was necessary. Mean maximum AVM nidal diameter was 8.2 mm. All deep-seated AVMs were completely resected without complications. All AVMs demonstrated complete obliteration on intraoperative angiogram and on 6-month follow-up angiogram. CONCLUSION: Minimally invasive tubular retractors are safe and present a promising surgical option for well-selected deep-seated AVMs. Furthermore, study may elucidate whether tubular retractors improve outcomes after microsurgical AVM resection secondary to mitigation of iatrogenic retraction injury risk.

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Section: Discussionmentioning

confidence: 99%

Surgical Resection of Deep-Seated Arteriovenous Malformations Through Stereotactically Guided Tubular Retractor Systems: A Case Series

Achey

Kashkoush

Potter

et al. 2023

Operative Neurosurgery

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“…Such an app is wished to be developed for lung ultrasound as a teaching software. At this stage, there is an increasing variety of small ultrasound probes in the market, especially portable probes 41–44 . For instance, Philips' lumify probe is both a probe and an ultrasound host, which requires only the connection with an Android smart device, either a tablet or a cell phone.…”

Section: Future Prospectivementioning

confidence: 99%

Clinical value of pulmonary congestion detection by lung ultrasound in patients with chronic heart failure

Zhu

Zeng

2021

Clinical Cardiology

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Chronic heart failure is one of the common causes of hospitalization and death. Pulmonary congestion is the common disease feature of patients with chronic heart failure, which could be correctly diagnosed by lung ultrasound. Efficacy of lung ultrasound‐guided pulmonary congestion management for patients with acute heart failure is well documented, however, more evidence is needed to establish the clinical value of pulmonary congestion detection by lung ultrasound examination in patients with chronic heart failure. This review summarized current evidence related to the use and clinical value of pulmonary congestion assessment by lung ultrasound in patients with chronic heart failure, aiming to provide new suggestions on promoting the widespread use of lung ultrasound in patients with chronic heart failure to improve the quality of life and outcome of patients with chronic heart failure.

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“…Focused ultrasound (FUS) is a non-invasive external excitation source with high spatial selectivity and deep tissue penetration, which could concentrate and enhance highfrequency sound waves at the focal point, enabling precise treatment of deep tissues without damage to surrounding tissue. [17][18][19] Hence, FUS as an excitation source can be used for drug delivery and release and biological function regulation. [20][21][22][23] For instance, nanoemulsions loaded with drugs can be triggered to release the payloads for non-invasive neuromodulation upon FUS.…”

Section: Introductionmentioning

confidence: 99%

Focused Ultrasound‐Responsive Nanocomposite with Near‐Infrared II Mechanoluminescence for Spatiotemporally Selective Immune Activation in Lymph Nodes

Xu,

Li,

et al. 2024

Chemistry A European J

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The immune regulation of the lymphatic system, especially the lymph node (LN), is of great significance for the treatment of diseases and the inhibition of pathogenic organisms spreading in the body. However, achieving precise spatiotemporal control of immune cell activation in LN in vivo remains a challenge due to tissue depth and off‐target effects. Furthermore, minimally invasive and real‐time feedback methods to monitor the regulation of the immune system in LN are lacking. Here, focused ultrasound responsive immunomodulator loaded nanoplatform (FURIN) with near‐infrared II (NIR‐II) luminescence is designed to achieve spatiotemporally controllable immune activation in LN. The NIR‐II persistent luminescence of FURIN can track its delivery in LN through bioimaging. Under focused ultrasound (FUS) stimulation, the immunomodulator encapsulated in FURIN can be released locally in LN to activate immune cells such as dendritic cells and the NIR‐II mechanoluminescence of FURIN provides real‐time optical feedback signals for immune activation. This work points to a FUS mediated, spatiotemporal selective immune activation strategy in vivo with the feedback control of luminescence signals via ultrasound responsive nanocomposite, which is of great significance in improving the efficacy and reducing the side effect of immune regulation for the development of potential immunotherapeutic methods in the future.

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Minimally invasive therapeutic ultrasound: Ultrasound-guided ultrasound ablation in neuro-oncology

Cited by 17 publications

References 18 publications

Surgical Resection of Deep-Seated Arteriovenous Malformations Through Stereotactically Guided Tubular Retractor Systems: A Case Series

Surgical Resection of Deep-Seated Arteriovenous Malformations Through Stereotactically Guided Tubular Retractor Systems: A Case Series

Clinical value of pulmonary congestion detection by lung ultrasound in patients with chronic heart failure

Focused Ultrasound‐Responsive Nanocomposite with Near‐Infrared II Mechanoluminescence for Spatiotemporally Selective Immune Activation in Lymph Nodes

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