Minimally Invasive Resynchronization Pacemaker: A Pediatric Animal Model

Jordan, Christopher P.; Wu, Kyle; Costello, John P.; Ishibashi, Nobuyuki; Krieger, Axel; Kane, Timothy D.; Kim, Peter; Berul, Charles I.

doi:10.1016/j.athoracsur.2013.07.057

Cited by 21 publications

(16 citation statements)

References 9 publications

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“…15 Younger age and decreased stature of patients undergoing nontransvenous implantation route as well as over-representation of the TGV and CV patients in the nontransvenous group confirm these expectations. The registry does not collect data on type of surgical repair (atrial versus arterial switch, for example, in TGV), associated anomalies, or specific contraindications to transvenous lead implantation.…”

Section: Discussionsupporting

confidence: 73%

Implant and Clinical Characteristics for Pediatric and Congenital Heart Patients in the National Cardiovascular Data Registry Implantable Cardioverter Defibrillator Registry

Jordan

Freedenberg

Wang

et al. 2014

Circ: Arrhythmia and Electrophysiology

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pediatric, nonatherosclerotic structural heart disease and congenital heart disease (CHD) data collection. This report characterizes CHD and pediatric patients undergoing implantable cardioverter defibrillator implantation. Methods and Results-In this article, we report implantable cardioverter defibrillator procedures (April 2010 to December 2012) in the registry for 2 cohorts: (1) all patients with CHD (atrial septal defect, ventricular septal defect, tetralogy of Fallot, Ebstein anomaly, transposition of the great vessels, and common ventricle) and (2) range, 61-203 cm; P<0.01) were lower than for transvenous patients. CHD and pediatrics had similar rates of transvenous (97%) and nontransvenous (3%) leads and did not differ from the overall registry. Transposition of the great vessels and common ventricle had higher rates of nontransvenous leads. Conclusions-Primary prevention exceeds secondary prevention for CHD and pediatrics. Nontransvenous lead patients were younger, with higher rates of transposition of the great vessels and common ventricle patients compared with transvenous lead patients. (Circ Arrhythm Electrophysiol. 2014;7:1092-1100.)

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Section: Discussionsupporting

confidence: 73%

Implant and Clinical Characteristics for Pediatric and Congenital Heart Patients in the National Cardiovascular Data Registry Implantable Cardioverter Defibrillator Registry

Jordan

Freedenberg

Wang

et al. 2014

Circ: Arrhythmia and Electrophysiology

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“…Compared to a canine model, the porcine coronary anatomy more closely resembles a human heart 11,12 and is the model of choice for studies focused on heart development, pediatric cardiology and/or congenital heart defects 13 . Although there are differences between the pig and human heart 8 , these similarities make the porcine heart a valuable model for cardiovascular research 14 .…”

Section: Introductionmentioning

confidence: 99%

Optocardiography and Electrophysiology Studies of Ex Vivo Langendorff-perfused Hearts

Swift

Jaimes

McCullough

et al. 2019

JoVE

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Small animal models are most commonly used in cardiovascular research due to the availability of genetically modified species and lower cost compared to larger animals. Yet, larger mammals are better suited for translational research questions related to normal cardiac physiology, pathophysiology, and preclinical testing of therapeutic agents. To overcome the technical barriers associated with employing a larger animal model in cardiac research, we describe an approach to measure physiological parameters in an isolated, Langendorff-perfused piglet heart. This approach combines two powerful experimental tools to evaluate the state of the heart: electrophysiology (EP) study and simultaneous optical mapping of transmembrane voltage and intracellular calcium using parameter sensitive dyes (RH237, Rhod2-AM). The described methodologies are well suited for translational studies investigating the cardiac conduction system, alterations in action potential morphology, calcium handling, excitation-contraction coupling and the incidence of cardiac alternans or arrhythmias. Video Link The video component of this article can be found at https://www.jove.com/video/60472/ 18,19. Indeed, simultaneous dual imaging of voltage and calcium-sensitive fluorescent probes allows for the assessment of electrical activity, calcium handling and excitation-contraction coupling at the tissue level

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“…In infants and small children with low body weight, the non‐transvenous systems have superiority since they can protect the vasculature and reduce the morbidity and mortality related to endocardial leads . Less invasive percutaneous epicardial resynchronization therapy options are also reported in animal models …”

Section: Discussionmentioning

confidence: 99%

“…14 Less invasive percutaneous epicardial resynchronization therapy options are also reported in animal models. 15 During the implantation, we encircled the coil with one turn and gradually increased the coil turn to 1.5 turns in order to achieve the maximum diameter length of the circle without compromising the strength of the coil. However, we implemented the coil with 1.5 turns in all of our patients.…”

Section: Discussionmentioning

confidence: 99%

Implantation of Looped Epicardial Cardioverter Defibrillator Coil on the Surface of the Right Ventricular Outflow Tract

et al. 2015

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Minimally Invasive Resynchronization Pacemaker: A Pediatric Animal Model

Cited by 21 publications

References 9 publications

Implant and Clinical Characteristics for Pediatric and Congenital Heart Patients in the National Cardiovascular Data Registry Implantable Cardioverter Defibrillator Registry

Implant and Clinical Characteristics for Pediatric and Congenital Heart Patients in the National Cardiovascular Data Registry Implantable Cardioverter Defibrillator Registry

Optocardiography and Electrophysiology Studies of Ex Vivo Langendorff-perfused Hearts

Implantation of Looped Epicardial Cardioverter Defibrillator Coil on the Surface of the Right Ventricular Outflow Tract

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