Rheumatology 2011
DOI: 10.1016/b978-0-323-06551-1.00031-2
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Minimally invasive procedures

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“…The blood vessels of the inflamed rheumatoid synovium tend to be straight branching in RA, as opposed to the tortuous pattern seen in spondyloarthritides 13 . It is known that the quantity of proinflammatory cytokines and inflammatory cells is reduced in the synovial membrane of treated RA patients with low disease activity 14 . Pretreatment synovial inflammation and tumor necrosis factor-α expression correlated with therapeutic response to infliximab 15,16 , and it has been shown that synovial cell infiltration, particularly by macrophages, and macrophage-derived cytokine expression were reduced after prednisolone therapy, with a significant correlation to beneficial clinical effect 17 .…”
Section: What Specifically Have We Learned From Analysis Of the Synov...mentioning
confidence: 99%
“…The blood vessels of the inflamed rheumatoid synovium tend to be straight branching in RA, as opposed to the tortuous pattern seen in spondyloarthritides 13 . It is known that the quantity of proinflammatory cytokines and inflammatory cells is reduced in the synovial membrane of treated RA patients with low disease activity 14 . Pretreatment synovial inflammation and tumor necrosis factor-α expression correlated with therapeutic response to infliximab 15,16 , and it has been shown that synovial cell infiltration, particularly by macrophages, and macrophage-derived cytokine expression were reduced after prednisolone therapy, with a significant correlation to beneficial clinical effect 17 .…”
Section: What Specifically Have We Learned From Analysis Of the Synov...mentioning
confidence: 99%